General Information of the Cell Line
Cell Line ID
CL000216
Cell Line Name
NCI-N87
Synonyms
NCI N87
N87
N-87
NCI-H87
H87
H-87
NCIN87
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1603
Tissue Information
Liver
Disease
Gastric tubular adenocarcinoma (NCIt: C5473)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01233, Receptor tyrosine-protein kinase erbB-2
Compound ID Compound Name Compound Formula
CP0137470
3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-6-yl}-1-{4-[4-(3-methoxypropyl)piperazin-1-yl]cyclohexyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C34H43N9O2
 1
1
EC50 = 94 nM
   TI
   LI
   LO
   TS
CP0198587
1-{4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-6-yl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C34H41N9O
 1
1
EC50 = 147 nM
   TI
   LI
   LO
   TS
CP0198677
3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-6-yl}-1-[4-(piperazin-1-yl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C30H35N9O
 1
1
EC50 = 210 nM
   TI
   LI
   LO
   TS
CP0269331
1-{4-[4-(4-amino-3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-6-yl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl]piperazin-1-yl}ethan-1-one
   Show/Hide
C32H37N9O2
 1
1
EC50 = 660 nM
   TI
   LI
   LO
   TS
CP0245059
4-[4-(4-amino-3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-6-yl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl]-N,N-dimethylpiperazine-1-carboxamide
   Show/Hide
C33H40N10O2
 1
1
EC50 = 1580 nM
   TI
   LI
   LO
   TS
CP0352335
ethyl 4-[4-(4-amino-3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-6-yl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl]piperazine-1-carboxylate
   Show/Hide
C33H39N9O3
 1
1
EC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0204110
N-[3-[5-[2-[4-[2-(dimethylamino)ethyl]anilino]pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2,6-difluorobenzamide
   Show/Hide
C32H27F2N7OS
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0301436
N-[3-[5-[2-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2,6-difluorobenzamide
   Show/Hide
C34H30F2N8OS
 1
1
IC50 = 69 nM
   TI
   LI
   LO
   TS
CP0007142
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
   Show/Hide
C29H26ClFN4O4S
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0290732
2-phenyl-N-(3-(5-(2-(1,2,3,4-tetrahydroisoquinolin-6-ylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)acetamide
   Show/Hide
C32H27N7OS
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0294102
N-[3-[5-[2-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide
   Show/Hide
C35H34N8OS
 1
1
IC50 = 310 nM
   TI
   LI
   LO
   TS
CP0093135
N-[3-[5-[2-(3-morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide
   Show/Hide
C33H29N7O2S
 1
1
IC50 = 680 nM
   TI
   LI
   LO
   TS
CP0037987
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
   Show/Hide
C22H23N3O4
 1
1
IC50 = 5200 nM
   TI
   LI
   LO
   TS
CP0095983
(1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol
   Show/Hide
C26H23N5O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0003580
Faridak
   Show/Hide
C21H23N3O2  1
1
IC50 = 8.42 nM
   TI
   LI
   LO
   TS
CP0007142
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
   Show/Hide
C29H26ClFN4O4S  1
1
IC50 = 53 nM
   TI
   LI
   LO
   TS
CP0016487
BMS-777607
   Show/Hide
C25H19ClF2N4O4  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0036082
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
   Show/Hide
C22H24ClFN4O3  1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0039472
4-N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]-5-[(E)-piperidin-1-yliminomethyl]pyrimidine-4,6-diamine
   Show/Hide
C24H25FN8  1
1
IC50 = 365 nM
   TI
   LI
   LO
   TS
CP0060035
5-(2-aminoethoxymethyl)-N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine
   Show/Hide
C23H22FN7O  1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0070350
(E)-4-(diethylamino)-1-[4-(3-ethynylanilino)-7,8-dihydropyrimido[5,4-g][1,4]benzoxazin-6-yl]but-2-en-1-one
   Show/Hide
C26H27N5O2  1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0144274
5-(((1,4-oxazepan-6-yl)methoxy)methyl)-N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C27H28FN7O2  1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0144278
(R)-N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((morpholin-3-ylmethoxy)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C26H26FN7O2  1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0145851
(R)-N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((morpholin-2-ylmethoxy)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C26H26FN7O2  1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0145858
(S)-5-((morpholin-2-ylmethoxy)methyl)-N-(1-(pyridin-2-ylmethyl)-1H-indazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C25H26N8O2  1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0187101
N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-amine
   Show/Hide
C21H17FN6  1
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
CP0227701
[(3S)-morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate
   Show/Hide
C27H27FN8O3  1
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
CP0251198
5-[2-(octylcarbamoyl)phenyl]-N-(3-pyrrolidin-1-ylpropyl)pyridine-3-carboxamide
   Show/Hide
C28H40N4O2  1
1
IC50 = 50000 nM
   TI
   LI
   LO
   TS
CP0264631
5-[2-[4-[3-(3,4-dichlorophenyl)propanoyl]piperazin-1-yl]phenyl]-N-(3-pyrrolidin-1-ylpropyl)pyridine-3-carboxamide
   Show/Hide
C32H37Cl2N5O2  1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0309328
N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]-5-(piperidin-4-ylmethoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
   Show/Hide
C27H28FN7O  1
1
IC50 = 720 nM
   TI
   LI
   LO
   TS
CP0309342
2-((4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)methoxy)acetamide
   Show/Hide
C23H20FN7O2  1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0318731
5-(Dimethyl-hydrazonomethyl)-N-[1-(3-fluoro-benzyl)-1H-indazol-5-yl]-pyrimidine-4,6-diamine
   Show/Hide
C21H21FN8  1
1
IC50 = 131 nM
   TI
   LI
   LO
   TS
CP0335787
(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)methanol
   Show/Hide
C21H17FN6O  1
1
IC50 = 7400 nM
   TI
   LI
   LO
   TS
CP0340906
N-[1-[(1R)-1-(3-fluorophenyl)ethyl]indazol-5-yl]-5-[[(2S)-morpholin-2-yl]methoxymethyl]pyrrolo[2,1-f][1,2,4]triazin-4-amine
   Show/Hide
C27H28FN7O2  1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0357802
5-(((S)-morpholin-2-ylmethoxy)methyl)-N-(1-((R)-1-phenylethyl)-1H-indazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C27H29N7O2  1
1
IC50 = 660 nM
   TI
   LI
   LO
   TS
CP0358496
N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]-5-(piperidin-4-yloxymethyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
   Show/Hide
C26H26FN7O  1
1
IC50 = 330 nM
   TI
   LI
   LO
   TS
CP0364773
(S)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-5-((morpholin-2-ylmethoxy)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C25H25ClFN5O3  1
1
IC50 = 610 nM
   TI
   LI
   LO
   TS
CP0364775
(S)-N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-6-methoxy-5-((morpholin-2-ylmethoxy)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C27H28FN7O3  1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0369257
(S)-N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((piperidin-3-ylmethoxy)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C27H28FN7O  1
1
IC50 = 980 nM
   TI
   LI
   LO
   TS
CP0399584
(R)-N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-5-((3-aminopyrrolidin-1-yl)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C25H25FN8  1
1
IC50 = 830 nM
   TI
   LI
   LO
   TS
CP0409404
N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]-5-[[4-(2-methylsulfonylethylamino)piperidin-1-yl]methyl]pyrrolo[2,1-f][1,2,4]triazin-4-amine
   Show/Hide
C29H33FN8O2S  1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0432356
2-piperidin-4-ylethyl N-[4-[(1-benzylindazol-5-yl)amino]-5-ethyl-7aH-pyrrolo[2,3-d]pyrimidin-6-yl]carbamate
   Show/Hide
C30H34N8O2  1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0437531
(E)-1-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-8,9-dihydro-7H-pyrimido[5,4-h][1,5]benzoxazepin-6-yl]-4-piperidin-1-ylbut-2-en-1-one
   Show/Hide
C33H33ClFN5O3  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0452778
5-((4-aminopiperidin-1-yl)methyl)-N-(3-chloro-4-((5-methylpyridin-3-yl)methoxy)phenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C25H28ClN7O  1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0453901
5-((4-aminopiperidin-1-yl)methyl)-N-(1-(pyridin-3-ylmethyl)-1H-indazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C25H27N9  1
1
IC50 = 86 nM
   TI
   LI
   LO
   TS
CP0464652
5-[(4-amino-4-methylpiperidin-1-yl)methyl]-N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine
   Show/Hide
C27H29FN8  1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CP0467822
2-(1-((4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)methyl)piperidin-4-ylamino)ethanol
   Show/Hide
C28H31FN8O  1
1
IC50 = 73 nM
   TI
   LI
   LO
   TS
CP0467823
5-[[4-(aminomethyl)piperidin-1-yl]methyl]-N-[1-[(3-fluorophenyl)methyl]indazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine
   Show/Hide
C27H29FN8  1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0472044
2-morpholin-4-ylethyl N-[4-[(1-benzylindazol-5-yl)amino]-5-ethyl-7aH-pyrrolo[2,3-d]pyrimidin-6-yl]carbamate
   Show/Hide
C29H32N8O3  1
1
IC50 = 520 nM
   TI
   LI
   LO
   TS
CP0484069
5-((1,4-diazepan-1-yl)methyl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C25H26ClFN6O  1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0496952
(4-aminocyclohexyl) N-[4-[(1-benzylindazol-5-yl)amino]-5-ethyl-7aH-pyrrolo[2,3-d]pyrimidin-6-yl]carbamate
   Show/Hide
C29H32N8O2  1
1
IC50 = 540 nM
   TI
   LI
   LO
   TS
CP0501034
piperidin-3-ylmethyl N-[4-[(1-benzylindazol-5-yl)amino]-5-ethyl-7aH-pyrrolo[2,3-d]pyrimidin-6-yl]carbamate
   Show/Hide
C29H32N8O2  1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0511622
5-((4-aminopiperidin-1-yl)methyl)-N-(1-(pyridin-2-ylmethyl)-1H-indazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
   Show/Hide
C25H27N9  1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0511624
N-[1-[[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-4-yl]-2-hydroxyacetamide
   Show/Hide
C28H29FN8O2  1
1
IC50 = 310 nM
   TI
   LI
   LO
   TS
CP0511625
5-[(4-aminopiperidin-1-yl)methyl]-N-[3-chloro-4-[(1-oxidopyridin-1-ium-2-yl)methoxy]phenyl]pyrrolo[2,1-f][1,2,4]triazin-4-amine
   Show/Hide
C24H26ClN7O2  1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0525985
(E)-1-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-7,8-dihydropyrimido[5,4-g][1,4]benzoxazin-6-yl]-4-(4-methylpiperazin-1-yl)but-2-en-1-one
   Show/Hide
C32H32ClFN6O3  1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0560229
(E)-1-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-8,9-dihydro-7H-pyrimido[5,4-h][1,5]benzoxazepin-6-yl]-4-(4-methylpiperidin-1-yl)but-2-en-1-one
   Show/Hide
C34H35ClFN5O3  1
1
IC50 = 838 nM
   TI
   LI
   LO
   TS
CP0562232
(E)-1-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-7,8-dihydropyrimido[5,4-g][1,4]benzoxazin-6-yl]-4-(4-methylpiperidin-1-yl)but-2-en-1-one
   Show/Hide
C33H33ClFN5O3  1
1
IC50 = 166 nM
   TI
   LI
   LO
   TS
CP0570582
(E)-1-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-8,9-dihydro-7H-pyrimido[5,4-h][1,5]benzoxazepin-6-yl]-4-(diethylamino)but-2-en-1-one
   Show/Hide
C32H33ClFN5O3  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Liver)
Cell Line Name Organism Disease
Huh-7 Homo sapiens (Human) Adult hepatocellular carcinoma
HLF Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-7-Lunet Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-7.5 Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-5-2 Homo sapiens (Human) Adult hepatocellular carcinoma
PLC/PRF/5 Homo sapiens (Human) Adult hepatocellular carcinoma
Hep 3B2.1-7 Homo sapiens (Human) Childhood hepatocellular carcinoma
VACO 241 Homo sapiens (Human) Colon carcinoma
LM Homo sapiens (Human) Extrarenal rhabdoid tumor of the liver
GTL-16 Homo sapiens (Human) Gastric adenocarcinoma
MKN45 Homo sapiens (Human) Gastric adenocarcinoma
Hep-G2 Homo sapiens (Human) Hepatoblastoma
Hep-G2/C3A Homo sapiens (Human) Hepatoblastoma
CellSensor ARE-bla Hep G2 Homo sapiens (Human) Hepatoblastoma
Hep-G2 VA-13 Homo sapiens (Human) Hepatoblastoma
HepDES19 Homo sapiens (Human) Hepatoblastoma
DPX2 Homo sapiens (Human) Hepatoblastoma
Hep-G2/2.2.15 Homo sapiens (Human) Hepatoblastoma
HepAD38 Homo sapiens (Human) Hepatoblastoma
HepG2-Lucia AhR Homo sapiens (Human) Hepatoblastoma
HepG2-hNTCP Homo sapiens (Human) Hepatoblastoma
HCCC-9810 Homo sapiens (Human) Intrahepatic cholangiocarcinoma
SU.86.86 Homo sapiens (Human) Pancreatic adenocarcinoma
Capan-1 Homo sapiens (Human) Pancreatic ductal adenocarcinoma
Hepa-1c1c7 Mus musculus (Mouse) Hepatocellular carcinoma of the mouse
H5 Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H4-II-E Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H4-II-E-C3 Rattus norvegicus (Rat) Rat hepatocellular carcinoma
McA-RH7777 Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H2.35 Mus musculus (Mouse) -