General Information of the Cell Line
Cell Line ID
CL000273
Cell Line Name
Hep 3B2.1-7
Synonyms
Hep 3B2_1-7
HEP3B217
Hep 3B2
HEP-3B2
HEP3B2
Hep-3B
HEP-3B
Hep 3B
Hep3B
HEP3B
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0326
Tissue Information
Liver
Disease
Childhood hepatocellular carcinoma (NCIt: C7955)
Pediatric hepatocellular carcinoma (ORDO: Orphanet_33402)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01286, Bile acid receptor
 Protein Info 
Compound ID Compound Name Compound Formula
CP0556636
 Compound Info 
3-[(1S)-1-(6-chloro-1-methylbenzimidazol-2-yl)-2-[1-(2-methylpropanoyl)piperidin-4-yl]ethyl]-1-(4-phenoxyphenyl)imidazolidine-2,4-dione
   Show/Hide
C34H36ClN5O4
  1
1
IC50 = 0.05 nM
 Bioactivity Info 
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CP0561829
 Compound Info 
3-[(1S)-1-(5-fluoro-1-methylbenzimidazol-2-yl)-2-[1-(2-methylpropanoyl)piperidin-4-yl]ethyl]-1-(4-phenoxyphenyl)imidazolidine-2,4-dione
   Show/Hide
C34H36FN5O4
  1
1
IC50 = 0.06 nM
 Bioactivity Info 
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CP0364655
 Compound Info 
3-[(1S)-2-(1-acetylpiperidin-4-yl)-1-(1,6-dimethylbenzimidazol-2-yl)ethyl]-1-(4-phenoxyphenyl)imidazolidine-2,4-dione
   Show/Hide
C33H35N5O4
  1
1
IC50 = 0.2 nM
 Bioactivity Info 
   TI
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CP0489955
 Compound Info 
3-[(1S)-2-(1-acetylpiperidin-4-yl)-1-(6-chloro-1-methylbenzimidazol-2-yl)ethyl]-1-(4-phenoxyphenyl)imidazolidine-2,4-dione
   Show/Hide
C32H32ClN5O4
  1
1
IC50 = 0.8 nM
 Bioactivity Info 
   TI
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CP0537010
 Compound Info 
3-[(1S)-2-(1-acetylpiperidin-4-yl)-1-(5-fluoro-1-methylbenzimidazol-2-yl)ethyl]-1-(4-phenoxyphenyl)imidazolidine-2,4-dione
   Show/Hide
C32H32FN5O4
  1
1
IC50 = 1 nM
 Bioactivity Info 
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CP0224620
 Compound Info 
3-[(1S)-1-(1,6-dimethylbenzimidazol-2-yl)-2-piperidin-4-ylethyl]-1-(4-phenoxyphenyl)imidazolidine-2,4-dione
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C31H33N5O3
  1
1
IC50 = 4510 nM
 Bioactivity Info 
   TI
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CP0354505
 Compound Info 
3-[(1S)-1-(1,6-dimethylbenzimidazol-2-yl)-2-[1-(2-methylpropyl)piperidin-4-yl]ethyl]-1-(4-phenoxyphenyl)imidazolidine-2,4-dione
   Show/Hide
C35H41N5O3
  1
1
IC50 = 17400 nM
 Bioactivity Info 
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Protein ID: PT02536, Diacylglycerol O-acyltransferase 1
 Protein Info 
Protein ID: PT02612, Egl nine homolog 1
 Protein Info 
Protein ID: PT02791, Hypoxia-inducible factor 1-alpha
 Protein Info 
Protein ID: PT01503, Signal transducer and activator of transcription 3
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0040077
 Compound Info 
(3beta)-3-hydroxyurs-12-en-28-oic acid
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 C30H48O3  1
1
IC50 = 23800 nM
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CP0278527
 Compound Info 
5-[6-(2-hydroxypropan-2-yl)-5,6-dihydrofuro[3,2-f][1]benzofuran-2-yl]benzene-1,3-diol
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 C19H18O5  1
1
IC50 > 30000 nM
   TI
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CP0380728
 Compound Info 
[2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-6-yl] 4-(3-nitrophenyl)benzoate
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 C24H21NO6  1
1
IC50 > 30000 nM
   TI
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CP0380729
 Compound Info 
2-[2-(4-methoxyphenyl)-5,6-dihydrofuro[3,2-f][1]benzofuran-6-yl]propan-2-ol
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 C20H20O4  1
1
IC50 > 30000 nM
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CP0384289
 Compound Info 
(1S,2R,4aS,6aR,6aS,6bR,8aR,10E,12aR,14bS)-10-(diaminomethylidenehydrazinylidene)-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,5,6,6a,7,8,8a,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
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 C31H50N4O2  1
1
IC50 > 100000 nM
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CP0384293
 Compound Info 
(1S,2R,4aS,6aR,6aS,6bR,8aR,10Z,11E,12aR,14bS)-10-(diaminomethylidenehydrazinylidene)-1,2,6a,6b,9,9,12a-heptamethyl-11-[(4-nitrophenyl)methylidene]-2,3,4,5,6,6a,7,8,8a,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid
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 C38H53N5O4  1
1
IC50 > 100000 nM
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CP0385278
 Compound Info 
2-(2-phenyl-5,6-dihydrofuro[3,2-f][1]benzofuran-6-yl)propan-2-ol
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 C19H18O3  1
1
IC50 > 30000 nM
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CP0390207
 Compound Info 
ethyl 2-[4-[6-(2-hydroxypropan-2-yl)-5,6-dihydrofuro[3,2-f][1]benzofuran-2-yl]phenoxy]acetate
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 C23H24O6  1
1
IC50 > 30000 nM
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CP0397273
 Compound Info 
2-(2-pyridin-4-yl-5,6-dihydrofuro[3,2-f][1]benzofuran-6-yl)propan-2-ol
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 C18H17NO3  1
1
IC50 > 30000 nM
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CP0417093
 Compound Info 
2-[2-(2H-tetrazol-5-yl)anilino]ethyl (1S,2R,4aS,6aR,6aS,6bR,8aR,12aR,14bS)-1,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,2,3,4,5,6,6a,7,8,8a,11,12,13,14b-tetradecahydropicene-4a-carboxylate
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 C39H55N5O3  1
1
IC50 > 100000 nM
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CP0424974
 Compound Info 
2-[2-(4-phenylmethoxyphenyl)-5,6-dihydrofuro[3,2-f][1]benzofuran-6-yl]propan-2-ol
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 C26H24O4  1
1
IC50 > 30000 nM
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CP0440573
 Compound Info 
pentyl (1S,2R,4aS,6aR,6aS,6bR,8aR,10E,12aR,14bS)-10-(diaminomethylidenehydrazinylidene)-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,5,6,6a,7,8,8a,11,12,13,14b-tetradecahydropicene-4a-carboxylate
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 C36H60N4O2  1
1
IC50 = 22000 nM
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CP0469447
 Compound Info 
(2,4-dichlorophenyl)methyl (1S,2R,4aS,6aR,6aS,6bR,8aR,10E,12aR,14bS)-10-(diaminomethylidenehydrazinylidene)-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,5,6,6a,7,8,8a,11,12,13,14b-tetradecahydropicene-4a-carboxylate
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 C38H54Cl2N4O2  1
1
IC50 > 100000 nM
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CP0474011
 Compound Info 
(3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-7-yl) 3-phenylmethoxybenzoate
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 C25H24O5  1
1
IC50 > 30000 nM
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CP0474012
 Compound Info 
[2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-6-yl] 3,5-bis(phenylmethoxy)benzoate
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 C32H30O6  1
1
IC50 > 30000 nM
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CP0478345
 Compound Info 
4-[(6R)-6-(2-hydroxypropan-2-yl)-5,6-dihydrofuro[3,2-f][1]benzofuran-2-yl]phenol
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 C19H18O4  1
1
IC50 > 30000 nM
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CP0492166
 Compound Info 
2-(2H-tetrazol-5-ylamino)ethyl (1S,2R,4aS,6aR,6aS,6bR,8aR,12aR,14bS)-1,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,2,3,4,5,6,6a,7,8,8a,11,12,13,14b-tetradecahydropicene-4a-carboxylate
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 C33H51N5O3  1
1
IC50 > 100000 nM
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CP0503452
 Compound Info 
(3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-7-yl) 3,5-bis(phenylmethoxy)benzoate
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 C32H30O6  1
1
IC50 > 30000 nM
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CP0503453
 Compound Info 
2-[2-(2-methoxyphenyl)-5,6-dihydrofuro[3,2-f][1]benzofuran-6-yl]propan-2-ol
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 C20H20O4  1
1
IC50 > 30000 nM
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CP0504875
 Compound Info 
(3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-7-yl) 4-phenylmethoxybenzoate
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 C25H24O5  1
1
IC50 > 30000 nM
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CP0504876
 Compound Info 
[2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-6-yl] 4-(3-methoxyphenyl)benzoate
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 C25H24O5  1
1
IC50 > 30000 nM
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CP0524735
 Compound Info 
(3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-7-yl) 2,4-difluorobenzoate
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 C18H16F2O4  1
1
IC50 > 30000 nM
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CP0524736
 Compound Info 
(3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-7-yl) 3,4-bis(phenylmethoxy)benzoate
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 C32H30O6  1
1
IC50 > 30000 nM
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CP0532094
 Compound Info 
[2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-6-yl] 3,5-dihydroxybenzoate
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 C18H18O6  1
1
IC50 > 30000 nM
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CP0533501
 Compound Info 
(1S,2R,4aS,6aR,6aS,6bR,8aR,10Z,11E,12aR,14bS)-10-(diaminomethylidenehydrazinylidene)-11-[(4-fluorophenyl)methylidene]-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid
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 C38H53FN4O2  1
1
IC50 > 100000 nM
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CP0533502
 Compound Info 
(1S,2R,4aS,6aR,6aS,6bR,8aR,10Z,11E,12aR,14bS)-10-(diaminomethylidenehydrazinylidene)-11-(furan-2-ylmethylidene)-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid
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 C36H52N4O3  1
1
IC50 > 100000 nM
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CP0536662
 Compound Info 
(3-chlorophenyl)methyl (1S,2R,4aS,6aR,6aS,6bR,8aR,10E,12aR,14bS)-10-(diaminomethylidenehydrazinylidene)-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,5,6,6a,7,8,8a,11,12,13,14b-tetradecahydropicene-4a-carboxylate
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 C38H55ClN4O2  1
1
IC50 = 34100 nM
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CP0536663
 Compound Info 
(1S,2R,4aS,6aR,6aS,6bR,8aR,10Z,11E,12aR,14bS)-11-benzylidene-10-(diaminomethylidenehydrazinylidene)-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid
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 C38H54N4O2  1
1
IC50 > 100000 nM
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CP0536664
 Compound Info 
(1S,2R,4aS,6aR,6aS,6bR,8aR,10Z,11E,12aR,14bS)-10-(diaminomethylidenehydrazinylidene)-11-[(2-fluorophenyl)methylidene]-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid
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 C38H53FN4O2  1
1
IC50 > 100000 nM
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CP0543920
 Compound Info 
(1S,2R,4aS,6aR,6aS,6bR,8aR,10Z,11E,12aR,14bS)-10-(diaminomethylidenehydrazinylidene)-11-[(2,4-dichlorophenyl)methylidene]-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid
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 C38H52Cl2N4O2  1
1
IC50 > 100000 nM
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CP0549829
 Compound Info 
3-[5-(1,3-benzodioxol-5-yl)tetrazol-1-yl]propyl (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
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 C41H58N4O5  1
1
IC50 > 100000 nM
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CP0552774
 Compound Info 
2-(5-phenyltetrazol-1-yl)ethyl (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
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 C39H56N4O3  1
1
IC50 > 100000 nM
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CP0556353
 Compound Info 
3-[3-(2H-tetrazol-5-yl)anilino]propyl (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
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 C40H59N5O3  1
1
IC50 > 100000 nM
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CP0556636
 Compound Info 
3-[(1S)-1-(6-chloro-1-methylbenzimidazol-2-yl)-2-[1-(2-methylpropanoyl)piperidin-4-yl]ethyl]-1-(4-phenoxyphenyl)imidazolidine-2,4-dione
   Show/Hide
 C34H36ClN5O4  1
1
IC50 > 100000 nM
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CP0561829
 Compound Info 
3-[(1S)-1-(5-fluoro-1-methylbenzimidazol-2-yl)-2-[1-(2-methylpropanoyl)piperidin-4-yl]ethyl]-1-(4-phenoxyphenyl)imidazolidine-2,4-dione
   Show/Hide
 C34H36FN5O4  1
1
IC50 > 100000 nM
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CP0562959
 Compound Info 
2-[5-(1,3-benzodioxol-5-yl)tetrazol-1-yl]ethyl (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
   Show/Hide
 C40H56N4O5  1
1
IC50 > 100000 nM
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CP0567473
 Compound Info 
(4-methylphenyl)methyl (1S,2R,4aS,6aR,6aS,6bR,8aR,10E,12aR,14bS)-10-(diaminomethylidenehydrazinylidene)-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,5,6,6a,7,8,8a,11,12,13,14b-tetradecahydropicene-4a-carboxylate
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 C39H58N4O2  1
1
IC50 = 18000 nM
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CP0569444
 Compound Info 
(1S,2R,4aS,6aR,6aS,6bR,8aR,12aR,14bS)-1,2,6a,6b,9,9,12a-heptamethyl-10-oxo-N-(2H-tetrazol-5-yl)-1,2,3,4,5,6,6a,7,8,8a,11,12,13,14b-tetradecahydropicene-4a-carboxamide
   Show/Hide
 C31H47N5O2  1
1
IC50 > 100000 nM
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CP0570024
 Compound Info 
3-[2-(2H-tetrazol-5-yl)anilino]propyl (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
   Show/Hide
 C40H59N5O3  1
1
IC50 > 100000 nM
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CP0576295
 Compound Info 
(1S,2R,4aS,6aR,6aS,6bR,8aR,10Z,11E,12aR,14bS)-11-[(2-chlorophenyl)methylidene]-10-(diaminomethylidenehydrazinylidene)-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid
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 C38H53ClN4O2  1
1
IC50 > 100000 nM
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CP0898157
 Compound Info 
4-[6-(1-Hydroxy-1-methyl-ethyl)-5,6-dihydro-benzo[1,2-b:5,4-b']difuran-2-yl]-phenol
   Show/Hide
 C19H18O4  1
1
IC50 > 30000 nM
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Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Liver)
Cell Line Name Organism Disease
Huh-7
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
HLF
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-7-Lunet
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-7.5
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-5-2
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
PLC/PRF/5
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
VACO 241
 Cell Line Info 
Homo sapiens (Human) Colon carcinoma
LM
 Cell Line Info 
Homo sapiens (Human) Extrarenal rhabdoid tumor of the liver
GTL-16
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
MKN45
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
NCI-N87
 Cell Line Info 
Homo sapiens (Human) Gastric tubular adenocarcinoma
Hep-G2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2/C3A
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
CellSensor ARE-bla Hep G2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2 VA-13
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepDES19
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
DPX2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2/2.2.15
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepAD38
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepG2-Lucia AhR
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepG2-hNTCP
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HCCC-9810
 Cell Line Info 
Homo sapiens (Human) Intrahepatic cholangiocarcinoma
SU.86.86
 Cell Line Info 
Homo sapiens (Human) Pancreatic adenocarcinoma
Capan-1
 Cell Line Info 
Homo sapiens (Human) Pancreatic ductal adenocarcinoma
Hepa-1c1c7
 Cell Line Info 
Mus musculus (Mouse) Hepatocellular carcinoma of the mouse
H5
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H4-II-E
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H4-II-E-C3
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
McA-RH7777
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H2.35
 Cell Line Info 
Mus musculus (Mouse) -