General Information of the Cell Line
Cell Line ID
CL000499
Cell Line Name
HepDES19
Synonyms
DES19
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_M179
Tissue Information
Liver
Disease
Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00295, Capsid protein
 Protein Info 
Compound ID Compound Name Compound Formula
CP0451286
 Compound Info 
ethyl (4R)-4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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C21H22BrFN4O3S
  1
1
EC50 = 45 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0444738
 Compound Info 
ethyl 4-(2-bromo-4-fluorophenyl)-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
   Show/Hide
C24H26BrFN4O4S
  1
1
EC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069893
 Compound Info 
Epivir
   Show/Hide
C8H11N3O3S
  1
1
EC50 = 370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419007
 Compound Info 
ethyl 4-(2-bromo-4-fluorophenyl)-6-[(1,3-dioxo-2,8-diazaspiro[4.5]decan-8-yl)methyl]-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
   Show/Hide
C25H25BrFN5O4S
  1
1
EC50 = 680 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0451289
 Compound Info 
ethyl 4-(2-bromo-4-fluorophenyl)-6-[(3-oxo-2,7-diazaspiro[3.5]nonan-7-yl)methyl]-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
   Show/Hide
C24H25BrFN5O3S
  1
1
EC50 = 1170 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0423573
 Compound Info 
ethyl 6-[(2-benzyl-1,3-dioxo-2,7-diazaspiro[4.4]nonan-7-yl)methyl]-4-(2-bromo-4-fluorophenyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
   Show/Hide
C31H29BrFN5O4S
  1
1
EC50 = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419018
 Compound Info 
ethyl 4-(2-bromo-4-fluorophenyl)-6-[(8-oxo-2,7-diazaspiro[4.4]nonan-2-yl)methyl]-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
   Show/Hide
C24H25BrFN5O3S
  1
1
EC50 = 2600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419011
 Compound Info 
ethyl 4-(2-bromo-4-fluorophenyl)-6-[(1-oxo-2,8-diazaspiro[4.5]decan-8-yl)methyl]-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
   Show/Hide
C25H27BrFN5O3S
  1
1
EC50 = 3430 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0451284
 Compound Info 
ethyl 4-(2-bromo-4-fluorophenyl)-6-[(3-oxo-2,8-diazaspiro[4.5]decan-8-yl)methyl]-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
   Show/Hide
C25H27BrFN5O3S
  1
1
EC50 = 3800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547766
 Compound Info 
tert-butyl 7-[[4-(2-bromo-4-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate
   Show/Hide
C29H35BrFN5O4S
  1
1
EC50 = 4830 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0451288
 Compound Info 
tert-butyl 2-[[4-(2-bromo-4-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-1-oxo-2,7-diazaspiro[4.4]nonane-7-carboxylate
   Show/Hide
C29H33BrFN5O5S
  1
1
EC50 = 5170 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0517079
 Compound Info 
tert-butyl 7-[[4-(2-bromo-4-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-2,7-diazaspiro[3.4]octane-2-carboxylate
   Show/Hide
C28H33BrFN5O4S
  1
1
EC50 = 8830 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0451056
 Compound Info 
tert-butyl 2-[[4-(2-bromo-4-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-2,7-diazaspiro[4.4]nonane-7-carboxylate
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C29H33BrFN5O5S
  1
1
EC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0444739
 Compound Info 
tert-butyl 7-[[4-(2-bromo-4-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate
   Show/Hide
C29H35BrFN5O4S
  1
1
EC50 = 10370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0520865
 Compound Info 
tert-butyl 6-[[4-(2-bromo-4-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-7-oxo-2,6-diazaspiro[3.4]octane-2-carboxylate
   Show/Hide
C28H31BrFN5O5S
  1
1
EC50 = 13270 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Liver)
Cell Line Name Organism Disease
Huh-7
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
HLF
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-7-Lunet
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-7.5
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-5-2
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
PLC/PRF/5
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Hep 3B2.1-7
 Cell Line Info 
Homo sapiens (Human) Childhood hepatocellular carcinoma
VACO 241
 Cell Line Info 
Homo sapiens (Human) Colon carcinoma
LM
 Cell Line Info 
Homo sapiens (Human) Extrarenal rhabdoid tumor of the liver
GTL-16
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
MKN45
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
NCI-N87
 Cell Line Info 
Homo sapiens (Human) Gastric tubular adenocarcinoma
Hep-G2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2/C3A
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
CellSensor ARE-bla Hep G2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2 VA-13
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
DPX2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2/2.2.15
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepAD38
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepG2-Lucia AhR
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepG2-hNTCP
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HCCC-9810
 Cell Line Info 
Homo sapiens (Human) Intrahepatic cholangiocarcinoma
SU.86.86
 Cell Line Info 
Homo sapiens (Human) Pancreatic adenocarcinoma
Capan-1
 Cell Line Info 
Homo sapiens (Human) Pancreatic ductal adenocarcinoma
Hepa-1c1c7
 Cell Line Info 
Mus musculus (Mouse) Hepatocellular carcinoma of the mouse
H5
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H4-II-E
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H4-II-E-C3
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
McA-RH7777
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H2.35
 Cell Line Info 
Mus musculus (Mouse) -