General Information of the Protein
Protein ID
PT00295
Protein Name
Capsid protein
Secondarily
Protein Name
Core antigen
Core protein
HBcAg
p21.5
Gene Name
HBCAG
Secondarily
Gene Name
C
Sequence
MIFVLGGCRHKLVCSPAPCNFFHLCLIISCSCPTVHASKLCLGWLWGMHIDPYKEFGASVELLSFLPSDFFPSIRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMNLATWVGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
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Organism
Hepatitis B virus, HBV
Protein Classification
Structural protein
Function
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.
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Uniprot ID
Q03732
Subcellular Location
Secreted
Virion
Host cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000148 , Huh-7
Compound ID Compound Name Compound Formula
CP0086203
ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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C21H22BrFN4O3S
 13
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
2
EC50 = 11 nM
   TI
   LI
   LO
   TS
3
EC50 = 12 nM
   TI
   LI
   LO
   TS
4
EC50 = 15 nM
   TI
   LI
   LO
   TS
5
EC50 = 18 nM
   TI
   LI
   LO
   TS
6
EC50 = 19 nM
   TI
   LI
   LO
   TS
7
EC50 = 20 nM
   TI
   LI
   LO
   TS
8
EC50 = 33 nM
   TI
   LI
   LO
   TS
9
EC50 = 34 nM
   TI
   LI
   LO
   TS
10
EC50 = 39 nM
   TI
   LI
   LO
   TS
11
EC50 = 46 nM
   TI
   LI
   LO
   TS
12
EC50 = 87 nM
   TI
   LI
   LO
   TS
13
EC50 = 92 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0274362
BAY-414109
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C18H13ClF3N3O2
 1
1 IC50 = 430 nM