General Information of the Cell Line
Cell Line ID
CL000641
Cell Line Name
PLC/PRF/5
Synonyms
PLC-PRF-5
PLC PRF 5
PLC/PRF5
PLCPRF5
PLC-8024
PLC8024
PLC
Alexander cells
Alexander
Primary Liver Carcinoma/Poliomyelitis Research Foundation/5
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0485
Tissue Information
Liver
Disease
Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01820, Aminopeptidase N
Compound ID Compound Name Compound Formula
CP0393151
(2S)-N-hydroxy-4-methyl-2-[[1-[(2-phenylmethoxyphenyl)methyl]triazol-4-yl]methylcarbamoylamino]pentanamide
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C24H30N6O4
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0424085
(2S)-N-hydroxy-4-methyl-2-[[1-[(3-phenylmethoxyphenyl)methyl]triazol-4-yl]methylcarbamoylamino]pentanamide
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C24H30N6O4
 1
1
IC50 = 4900 nM
   TI
   LI
   LO
   TS
CP0566687
(2S)-2-[[1-[(2-ethoxyphenyl)methyl]triazol-4-yl]methylcarbamoylamino]-N-hydroxy-4-methylpentanamide
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C19H28N6O4
 1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0424086
(2S)-N-hydroxy-2-[[1-[1-(2-methoxyphenyl)ethyl]triazol-4-yl]methylcarbamoylamino]-4-methylpentanamide
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C19H28N6O4
 1
1
IC50 = 12300 nM
   TI
   LI
   LO
   TS
CP0560419
(2S)-N-hydroxy-2-[[1-[(2-methoxyphenyl)methyl]triazol-4-yl]methylcarbamoylamino]-4-methylpentanamide
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C18H26N6O4
 1
1
IC50 = 15300 nM
   TI
   LI
   LO
   TS
CP0472907
(2S)-N-hydroxy-4-methyl-2-[[1-[(2-methylphenyl)methyl]triazol-4-yl]methylcarbamoylamino]pentanamide
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C18H26N6O3
 1
1
IC50 = 20600 nM
   TI
   LI
   LO
   TS
CP0037780
(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid
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C16H24N2O4
 1
1
IC50 = 54700 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0007860
7-[2-(6-aminopyridin-3-yl)-6-morpholin-4-ylpurin-9-yl]-N-hydroxyheptanamide
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C21H28N8O3  1
1
IC50 = 1570 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Liver)
Cell Line Name Organism Disease
Huh-7 Homo sapiens (Human) Adult hepatocellular carcinoma
HLF Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-7-Lunet Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-7.5 Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-5-2 Homo sapiens (Human) Adult hepatocellular carcinoma
Hep 3B2.1-7 Homo sapiens (Human) Childhood hepatocellular carcinoma
VACO 241 Homo sapiens (Human) Colon carcinoma
LM Homo sapiens (Human) Extrarenal rhabdoid tumor of the liver
GTL-16 Homo sapiens (Human) Gastric adenocarcinoma
MKN45 Homo sapiens (Human) Gastric adenocarcinoma
NCI-N87 Homo sapiens (Human) Gastric tubular adenocarcinoma
Hep-G2 Homo sapiens (Human) Hepatoblastoma
Hep-G2/C3A Homo sapiens (Human) Hepatoblastoma
CellSensor ARE-bla Hep G2 Homo sapiens (Human) Hepatoblastoma
Hep-G2 VA-13 Homo sapiens (Human) Hepatoblastoma
HepDES19 Homo sapiens (Human) Hepatoblastoma
DPX2 Homo sapiens (Human) Hepatoblastoma
Hep-G2/2.2.15 Homo sapiens (Human) Hepatoblastoma
HepAD38 Homo sapiens (Human) Hepatoblastoma
HepG2-Lucia AhR Homo sapiens (Human) Hepatoblastoma
HepG2-hNTCP Homo sapiens (Human) Hepatoblastoma
HCCC-9810 Homo sapiens (Human) Intrahepatic cholangiocarcinoma
SU.86.86 Homo sapiens (Human) Pancreatic adenocarcinoma
Capan-1 Homo sapiens (Human) Pancreatic ductal adenocarcinoma
Hepa-1c1c7 Mus musculus (Mouse) Hepatocellular carcinoma of the mouse
H5 Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H4-II-E Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H4-II-E-C3 Rattus norvegicus (Rat) Rat hepatocellular carcinoma
McA-RH7777 Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H2.35 Mus musculus (Mouse) -