General Information of the Compound
| Compound ID |
CP0197654
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| Compound Name |
US9062045, Comparator No. 1 (JNJ-38877605)
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| Synonyms |
C-met inhibitor (solid tumors), ORD/J&J PRD
C-met inhibitor, Ortho Biotech Oncology Research & Development
JNJ-38877605
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| Structure |
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| Formula |
C19H13F2N7
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| Molecular Weight |
377.358
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| Canonical SMILES |
Cn1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1
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| InChI |
InChI=1S/C19H13F2N7/c1-27-11-13(10-23-27)16-6-7-17-24-25-18(28(17)26-16)19(20,21)14-4-5-15-12(9-14)3-2-8-22-15/h2-11H,1H3
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| InChIKey |
JRWCBEOAFGHNNU-UHFFFAOYSA-N
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| CAS |
943540-75-8
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01201, Hepatocyte growth factor receptor
Clinical Information about the Compound