Brief Information of the Compound and Protein
Compound Name
US9062045, Comparator No. 1 (JNJ-38877605)
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PubChem ID
CID: 46911863
Canonical SMILES
Cn1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1
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Compound Formula C19H13F2N7
Compound Structure
Protein Name
Hepatocyte growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
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TK protein kinase group
>
Tyrosine protein kinase Met family
Uniprot ID
P08581
Gene Name
MET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000504 EBC-1 Homo sapiens (Human)  1
1
IC50 = 5.5 nM
   TI
   LI
   LO
   TS
CL000413 MKN45 Homo sapiens (Human)  1
1
IC50 = 9.5 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.95 nM
2 IC50 = 1 nM
3 IC50 = 3 nM
4 IC50 = 4 nM