General Information of the Compound
Compound ID
CP0960189
Compound Name
US9427428, 10
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Structure
Formula
C42H50N8O8
Molecular Weight
794.91
Canonical SMILES
COCC[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc(-c2ccc3cc(-c4ccc5nc([C@@H]6CCCN6C(=O)[C@H](CCOC)NC(=O)OC)[nH]c5c4)ccc3c2)[nH]1
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InChI
InChI=1S/C42H50N8O8/c1-55-19-15-31(47-41(53)57-3)39(51)49-17-5-7-35(49)37-43-24-34(46-37)29-12-11-25-21-26(9-10-27(25)22-29)28-13-14-30-33(23-28)45-38(44-30)36-8-6-18-50(36)40(52)32(16-20-56-2)48-42(54)58-4/h9-14,21-24,31-32,35-36H,5-8,15-20H2,1-4H3,(H,43,46)(H,44,45)(H,47,53)(H,48,54)/t31-,32-,35-,36-/m0/s1
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InChIKey
WINJNVDNYURKLF-VOIOCNMVSA-N
Physicochemical Property
logP
5.6224
Rotatable Bonds
14
Heavy Atom Count
58
Polar Areas
193.1
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
10
Complexity
58

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 117879754
ChEMBL ID
CHEMBL3911256
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000322 Huh-7-Lunet Homo sapiens (Human)  1
1
EC50 = 1.032 nM
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