Brief Information of the Compound and Protein
Compound Name
(4Z)-4-ethoxyimino-5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-1,3-dihydroquinolin-3-ol
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PubChem ID
CID: 136000568
Canonical SMILES
CCO\N=C1/C(O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2c(C)c[nH]c12
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Compound Formula C22H23F2N3O2
Compound Structure
Protein Name
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
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Nuclear hormone receptor subfamily 3
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Nuclear hormone receptor subfamily 3 group C
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Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P04150
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000782 297L1 Homo sapiens (Human)  1
1
IC50 = 5.2 nM
   TI
   LI
   LO
   TS
CL000063 Hep-G2 Homo sapiens (Human)  3
1
EC50 = 1.5 nM
   TI
   LI
   LO
   TS
2
EC50 = 115 nM
   TI
   LI
   LO
   TS
3
IC50 = 2.6 nM
   TI
   LI
   LO
   TS