Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US8497274, 32
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 PubChem ID
CID: 46209401
SID: 96063656
Canonical SMILES
Fc1ccc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2C#N)cc1NC(=O)Cc1cccc(c1)C(F)(F)F
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Compound Formula C27H18F4N4O3S
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
2
IC50 = 16 nM
   TI
   LI
   LO
   TS
CL000007 HT-29
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 75 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 3.23 nM
   TI
   LI
   LO
   TS
2
IC50 = 4.48 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 6.25E+17 nM