Brief Information of the Compound and Protein
Compound Name
 Compound Info 
Methyl N-[(2S)-1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate
    Show/Hide
 PubChem ID
CID: 51034121
SID: 117694291
Canonical SMILES
COC(=O)N[C@@H](C)CNc1nccc(-c2c[nH]nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1
    Show/Hide
Compound Formula C19H21ClFN7O4S
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.8 nM