General Information of the Cell Line
Cell Line ID
CL000212
Cell Line Name
Malme-3M
Synonyms
MALME-3M
MALME 3M
Malme-3 M
MALME.3M
Malme3M
MALME3M
Malme-3 Monolayer
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1438
Tissue Information
Lung
Disease
Melanoma (NCIt: C3224)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01381, Serine/threonine-protein kinase B-raf
 Protein Info 
Compound ID Compound Name Compound Formula
CP0731357
 Compound Info 
N-(2,4-Difluoro-3-(3-(3-methoxy-1H-pyrazolo[3,4-d]-pyrimidin-4-yl)ureido)phenyl)propane-1-sulfonamide
   Show/Hide
C16H17F2N7O4S
  1
1
EC50 = 2.6 nM
 Bioactivity Info 
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CP0079071
 Compound Info 
N-[2,4-difluoro-3-[8-methyl-2-[(1-methylpyrazol-4-yl)amino]-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]propane-1-sulfonamide
   Show/Hide
C21H21F2N7O3S
  1
1
IC50 = 1 nM
 Bioactivity Info 
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CP0680669
 Compound Info 
4-Amino-quinazoline-8-carboxylic Acid [6-Chloro-2-fluoro-3-(3-fluoro-propane-1-sulfonylamino)-phenyl]-amide
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C18H16ClF2N5O3S
  1
1
IC50 = 2.5 nM
 Bioactivity Info 
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CP0150824
 Compound Info 
N-[2,4-difluoro-3-[8-methyl-7-oxo-2-(pyridin-3-ylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]propane-1-sulfonamide
   Show/Hide
C22H20F2N6O3S
  1
1
IC50 = 3 nM
 Bioactivity Info 
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CP0480052
 Compound Info 
N-[2-cyano-4-fluoro-3-(3-methyl-4-oxoquinazolin-6-yl)oxyphenyl]propane-1-sulfonamide
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C19H17FN4O4S
  1
1
IC50 = 3 nM
 Bioactivity Info 
   TI
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CP0259404
 Compound Info 
4-amino-N-[6-chloro-2-fluoro-3-(3-fluoropropylsulfonylamino)phenyl]thieno[3,2-d]pyrimidine-7-carboxamide
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C16H14ClF2N5O3S2
  1
1
IC50 = 4.6 nM
 Bioactivity Info 
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CP0178685
 Compound Info 
N-[3-(2-anilino-8-methyl-7-oxopyrido[2,3-d]pyrimidin-6-yl)-2,4-difluorophenyl]propane-1-sulfonamide
   Show/Hide
C23H21F2N5O3S
  1
1
IC50 = 5 nM
 Bioactivity Info 
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CP0018614
 Compound Info 
N-[2-cyano-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]propane-1-sulfonamide
   Show/Hide
C19H19N5O3S
  1
1
IC50 = 6 nM
 Bioactivity Info 
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CP0415687
 Compound Info 
N-[2-cyano-3-(3-methyl-4-oxoquinazolin-6-yl)oxyphenyl]propane-1-sulfonamide
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C19H18N4O4S
  1
1
IC50 = 7 nM
 Bioactivity Info 
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CP0731366
 Compound Info 
4-Amino-quinazoline-8-carboxylic Acid [2-Chloro-6-fluoro-3-(propane-1-sulfonylamino)-phenyl]-amide
   Show/Hide
C18H17ClFN5O3S
  1
1
IC50 = 7.7 nM
 Bioactivity Info 
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CP0666211
 Compound Info 
4-Amino-quinazoline-8-carboxylic Acid [6-Chloro-2-fluoro-3-(propane-1-sulfonylamino)-phenyl]-amide
   Show/Hide
C18H17ClFN5O3S
  1
1
IC50 = 9.5 nM
 Bioactivity Info 
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CP0680668
 Compound Info 
4-Amino-quinazoline-8-carboxylic Acid [2,6-Difluoro-3-(propane-1-sulfonylamino)-phenyl]-amide
   Show/Hide
C18H17F2N5O3S
  1
1
IC50 = 9.5 nM
 Bioactivity Info 
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CP0114052
 Compound Info 
2,6-difluoro-N-(2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide
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C22H19F2N5O3S
  1
1
IC50 = 12 nM
 Bioactivity Info 
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CP0691627
 Compound Info 
4-Amino-thieno[3,2-d]pyrimidine-7-carboxylic Acid [2-Chloro-6-fluoro-3-(propane-1-sulfonylamino)-phenyl]-amide
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C16H15ClFN5O3S2
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0732545
 Compound Info 
4-Amino-thieno[3,2-d]pyrimidine-7-carboxylic Acid [2,6-Difluoro-3-(propane-1-sulfonylamino)-phenyl]-amide
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C16H15F2N5O3S2
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0554323
 Compound Info 
N-[4-chloro-2-cyano-3-(3-methyl-4-oxoquinazolin-6-yl)oxyphenyl]propane-1-sulfonamide
   Show/Hide
C19H17ClN4O4S
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0469341
 Compound Info 
N-[4-chloro-2-cyano-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]propane-1-sulfonamide
   Show/Hide
C19H18ClN5O3S
  1
1
IC50 = 16 nM
 Bioactivity Info 
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CP0437562
 Compound Info 
2-chloro-N-(3-cyclopropyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-6-fluoro-3-(2-methylpropylsulfonylamino)benzamide
   Show/Hide
C20H21ClFN5O3S
  1
1
IC50 = 18 nM
 Bioactivity Info 
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CP0541015
 Compound Info 
5-[[3-(2-cyanopropan-2-yl)benzoyl]amino]-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-2-methylbenzamide
   Show/Hide
C26H24N6O3
  1
1
IC50 = 18 nM
 Bioactivity Info 
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CP0435471
 Compound Info 
N-[2-chloro-4-fluoro-3-[[3-(1-methylpyrazol-4-yl)-4-oxoquinazolin-6-yl]amino]phenyl]propane-1-sulfonamide
   Show/Hide
C21H20ClFN6O3S
  1
1
IC50 = 18 nM
 Bioactivity Info 
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CP0104718
 Compound Info 
2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C17H17F2N5O4S
  1
1
IC50 = 19 nM
 Bioactivity Info 
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CP0496290
 Compound Info 
2-chloro-6-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C17H17ClFN5O4S
  1
1
IC50 = 19 nM
 Bioactivity Info 
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CP0731356
 Compound Info 
4-Amino-thieno[3,2-d]pyrimidine-7-carboxylic Acid [6-Chloro-2-fluoro-3-(propane-1-sulfonylamino)-phenyl]-amide
   Show/Hide
C16H15ClFN5O3S2
  1
1
IC50 = 19 nM
 Bioactivity Info 
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CP0212890
 Compound Info 
6-chloro-2-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C17H17ClFN5O4S
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0534333
 Compound Info 
5-[[3-(2-cyanopropan-2-yl)benzoyl]amino]-2-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
   Show/Hide
C25H21FN6O3
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0408930
 Compound Info 
2,6-difluoro-N-[2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C23H19F3N4O3S
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0465894
 Compound Info 
N-[2-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C23H19ClF2N4O3S
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0517631
 Compound Info 
2-chloro-5-[[3-(2-cyanopropan-2-yl)benzoyl]amino]-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
   Show/Hide
C25H21ClN6O3
  1
1
IC50 = 22 nM
 Bioactivity Info 
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CP0441235
 Compound Info 
N-(3-cyclopropyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C19H19F2N5O3S
  1
1
IC50 = 23 nM
 Bioactivity Info 
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CP0435470
 Compound Info 
N-[2-chloro-4-fluoro-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]propane-1-sulfonamide
   Show/Hide
C18H18ClFN4O3S
  1
1
IC50 = 26 nM
 Bioactivity Info 
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CP0198390
 Compound Info 
N-[3-[2-(cyclopropylmethylamino)-8-methyl-7-oxopyrido[2,3-d]pyrimidin-6-yl]-2,4-difluorophenyl]propane-1-sulfonamide
   Show/Hide
C21H23F2N5O3S
  1
1
IC50 = 27 nM
 Bioactivity Info 
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CP0068741
 Compound Info 
3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]benzamide
   Show/Hide
C27H25N5O2
  1
1
IC50 = 27 nM
 Bioactivity Info 
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CP0069656
 Compound Info 
N-[2,4-difluoro-3-[2-(2-hydroxyethylamino)-8-methyl-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]propane-1-sulfonamide
   Show/Hide
C19H21F2N5O4S
  1
1
IC50 = 31 nM
 Bioactivity Info 
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CP0391969
 Compound Info 
2,6-difluoro-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C23H20F2N4O3S
  1
1
IC50 = 32 nM
 Bioactivity Info 
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CP0496291
 Compound Info 
2-chloro-N-(3-cyclopropyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-6-fluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C19H19ClFN5O3S
  1
1
IC50 = 33 nM
 Bioactivity Info 
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CP0311242
 Compound Info 
N-(3-bromo-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C17H15BrF2N4O3S
  1
1
IC50 = 39 nM
 Bioactivity Info 
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CP0463049
 Compound Info 
N-[3-(dimethylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C18H20F2N6O3S
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0036068
 Compound Info 
1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
   Show/Hide
C24H16F6N6O
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0222857
 Compound Info 
N-[2,4-difluoro-3-[2-(3-hydroxypropylamino)-8-methyl-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]propane-1-sulfonamide
   Show/Hide
C20H23F2N5O4S
  1
1
IC50 = 41 nM
 Bioactivity Info 
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CP0461642
 Compound Info 
N-(3-bromo-2H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C16H14BrF2N5O3S
  1
1
IC50 = 44 nM
 Bioactivity Info 
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CP0480051
 Compound Info 
N-[2-chloro-4-fluoro-3-(quinazolin-6-ylamino)phenyl]propane-1-sulfonamide
   Show/Hide
C17H16ClFN4O2S
  1
1
IC50 = 44 nM
 Bioactivity Info 
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CP0083238
 Compound Info 
N-[2,4-difluoro-3-[8-methyl-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]propane-1-sulfonamide
   Show/Hide
C18H19F2N5O3S
  1
1
IC50 = 45 nM
 Bioactivity Info 
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CP0482458
 Compound Info 
2,6-difluoro-N-[2-(4-methylphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C23H21F2N5O3S
  1
1
IC50 = 49 nM
 Bioactivity Info 
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CP0488308
 Compound Info 
2-chloro-N-(3-cyclopropyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-6-fluoro-3-(3-fluoropropylsulfonylamino)benzamide
   Show/Hide
C19H18ClF2N5O3S
  1
1
IC50 = 51 nM
 Bioactivity Info 
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CP0499361
 Compound Info 
3-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-4-methyl-1-N-[3-(trifluoromethyl)phenyl]benzene-1,3-dicarboxamide
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C23H18F3N5O3
  1
1
IC50 = 52 nM
 Bioactivity Info 
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CP0385592
 Compound Info 
2,6-difluoro-N-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18F3N5O3S
  1
1
IC50 = 54 nM
 Bioactivity Info 
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CP0480411
 Compound Info 
N-[2,4-difluoro-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]propane-1-sulfonamide
   Show/Hide
C18H18F2N4O3S
  1
1
IC50 = 55 nM
 Bioactivity Info 
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CP0392515
 Compound Info 
6-chloro-2-fluoro-3-(propylsulfonylamino)-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
   Show/Hide
C16H15ClFN5O3S
  1
1
IC50 = 56 nM
 Bioactivity Info 
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CP0006321
 Compound Info 
PLX-4032
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C23H18ClF2N3O3S
  1
1
IC50 = 61 nM
 Bioactivity Info 
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CP0465886
 Compound Info 
N-[2-(4-bromophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18BrF2N5O3S
  1
1
IC50 = 61 nM
 Bioactivity Info 
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CP0392019
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
   Show/Hide
C16H15F2N5O3S
  1
1
IC50 = 62 nM
 Bioactivity Info 
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CP0435515
 Compound Info 
N-[2,4-difluoro-3-[methyl-(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]propane-1-sulfonamide
   Show/Hide
C19H20F2N4O3S
  1
1
IC50 = 62 nM
 Bioactivity Info 
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CP0379673
 Compound Info 
N-[2-(3-chlorophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18ClF2N5O3S
  1
1
IC50 = 68 nM
 Bioactivity Info 
   TI
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CP0346209
 Compound Info 
N-[2,4-difluoro-3-[8-methyl-2-(oxan-4-ylamino)-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]propane-1-sulfonamide
   Show/Hide
C22H25F2N5O4S
  1
1
IC50 = 73 nM
 Bioactivity Info 
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CP0522548
 Compound Info 
N-[2-(3,4-dichlorophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H17Cl2F2N5O3S
  1
1
IC50 = 81 nM
 Bioactivity Info 
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CP0415684
 Compound Info 
N-[4-chloro-2-fluoro-3-[methyl-(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]propane-1-sulfonamide
   Show/Hide
C19H20ClFN4O3S
  1
1
IC50 = 84 nM
 Bioactivity Info 
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CP0448127
 Compound Info 
2,6-difluoro-N-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C17H17F2N5O3S
  1
1
IC50 = 86 nM
 Bioactivity Info 
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CP0411677
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-[2-[4-(trifluoromethoxy)phenyl]-1H-imidazo[4,5-b]pyridin-6-yl]benzamide
   Show/Hide
C23H18F5N5O4S
  1
1
IC50 = 86 nM
 Bioactivity Info 
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CP0725615
 Compound Info 
N-(3-(3-1H-Pyrazolo[3,4-d]pyrimidin-4-ylureido)-2,4-difluorophenyl)propane-1-sulfonamide
   Show/Hide
C15H15F2N7O3S
  1
1
IC50 = 88 nM
 Bioactivity Info 
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CP0466816
 Compound Info 
2,6-difluoro-N-(3-propan-2-yl-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C19H21F2N5O3S
  1
1
IC50 = 89 nM
 Bioactivity Info 
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CP0411678
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-[2-[4-(trifluoromethyl)phenyl]-1H-imidazo[4,5-b]pyridin-6-yl]benzamide
   Show/Hide
C23H18F5N5O3S
  1
1
IC50 = 89 nM
 Bioactivity Info 
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CP0465887
 Compound Info 
N-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18ClF2N5O3S
  1
1
IC50 = 90 nM
 Bioactivity Info 
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CP0262132
 Compound Info 
N-[3-(2-amino-8-methyl-7-oxopyrido[2,3-d]pyrimidin-6-yl)-2,4-difluorophenyl]propane-1-sulfonamide
   Show/Hide
C17H17F2N5O3S
  1
1
IC50 = 93 nM
 Bioactivity Info 
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CP0069736
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide
   Show/Hide
C17H16F2N4O3S
  1
1
IC50 = 94 nM
 Bioactivity Info 
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CP0523640
 Compound Info 
4-chloro-N-[4-fluoro-3-[(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)carbamoyl]phenyl]-3-(trifluoromethyl)benzamide
   Show/Hide
C22H14ClF4N5O3
  1
1
IC50 = 96 nM
 Bioactivity Info 
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CP0415685
 Compound Info 
N-[3-[ethyl-(3-methyl-4-oxoquinazolin-6-yl)amino]-2,4-difluorophenyl]propane-1-sulfonamide
   Show/Hide
C20H22F2N4O3S
  1
1
IC50 = 110 nM
 Bioactivity Info 
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CP0408945
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-[2-[3-(trifluoromethyl)phenyl]-1H-imidazo[4,5-b]pyridin-6-yl]benzamide
   Show/Hide
C23H18F5N5O3S
  1
1
IC50 = 113 nM
 Bioactivity Info 
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CP0469344
 Compound Info 
N-[2-chloro-4-fluoro-3-[methyl-(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]propane-1-sulfonamide
   Show/Hide
C19H20ClFN4O3S
  1
1
IC50 = 114 nM
 Bioactivity Info 
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CP0469339
 Compound Info 
N-[4-chloro-2-fluoro-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]propane-1-sulfonamide
   Show/Hide
C18H18ClFN4O3S
  1
1
IC50 = 116 nM
 Bioactivity Info 
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CP0554322
 Compound Info 
N-[2,4-difluoro-3-(quinazolin-6-ylamino)phenyl]propane-1-sulfonamide
   Show/Hide
C17H16F2N4O2S
  1
1
IC50 = 118 nM
 Bioactivity Info 
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CP0391965
 Compound Info 
2,6-difluoro-N-(2-phenyl-1H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H19F2N5O3S
  1
1
IC50 = 132 nM
 Bioactivity Info 
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CP0547115
 Compound Info 
N-[2-chloro-4-fluoro-3-[[4-(methylamino)quinazolin-6-yl]amino]phenyl]propane-1-sulfonamide
   Show/Hide
C18H19ClFN5O2S
  1
1
IC50 = 132 nM
 Bioactivity Info 
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CP0408946
 Compound Info 
2,6-difluoro-N-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C23H21F2N5O4S
  1
1
IC50 = 137 nM
 Bioactivity Info 
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CP0508227
 Compound Info 
3-(2-cyanopropan-2-yl)-N-[3-[(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)carbamoyl]phenyl]benzamide
   Show/Hide
C25H22N6O3
  1
1
IC50 = 140 nM
 Bioactivity Info 
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CP0391964
 Compound Info 
N-[2-(4-chlorophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18ClF2N5O3S
  1
1
IC50 = 157 nM
 Bioactivity Info 
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CP0392024
 Compound Info 
2,6-difluoro-N-[2-(2-fluorophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18F3N5O3S
  1
1
IC50 = 167 nM
 Bioactivity Info 
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CP0732544
 Compound Info 
N-(2,4-Difluoro-3-(3-(6-(methylamino)pyrimidin-4-yl)-ureido)phenyl)propane-1-sulfonamide
   Show/Hide
C15H18F2N6O3S
  1
1
IC50 = 168 nM
 Bioactivity Info 
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CP0408947
 Compound Info 
N-[2-(3-bromophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18BrF2N5O3S
  1
1
IC50 = 172 nM
 Bioactivity Info 
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CP0507160
 Compound Info 
3-[[3-(2-cyanopropan-2-yl)benzoyl]amino]-2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
   Show/Hide
C25H20F2N6O3
  1
1
IC50 = 180 nM
 Bioactivity Info 
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CP0541207
 Compound Info 
N-[2-(3,4-difluorophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H17F4N5O3S
  1
1
IC50 = 194 nM
 Bioactivity Info 
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CP0465893
 Compound Info 
N-[2-(4-cyanophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C23H18F2N6O3S
  1
1
IC50 = 239 nM
 Bioactivity Info 
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CP0751189
 Compound Info 
N-(3-(3-(6-Aminopyrimidin-4-yl)-3-methylureido)-2,4-difluorophenyl)propane-1-sulfonamide
   Show/Hide
C15H18F2N6O3S
  1
1
IC50 = 240 nM
 Bioactivity Info 
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CP0391967
 Compound Info 
2,6-difluoro-N-[2-(3-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C23H21F2N5O4S
  1
1
IC50 = 271 nM
 Bioactivity Info 
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CP0556327
 Compound Info 
2,6-difluoro-N-[2-(3-fluorophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18F3N5O3S
  1
1
IC50 = 298 nM
 Bioactivity Info 
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CP0448128
 Compound Info 
N-(6-amino-5-bromopyridin-3-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
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C15H15BrF2N4O3S
  1
1
IC50 = 310 nM
 Bioactivity Info 
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CP0449564
 Compound Info 
3-[[3-(2-cyanopropan-2-yl)benzoyl]amino]-2,6-difluoro-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
   Show/Hide
C24H18F2N6O2
  1
1
IC50 = 430 nM
 Bioactivity Info 
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CP0680665
 Compound Info 
N-(3-(3-(6-Aminopyrimidin-4-yl)ureido)-2,4-difluorophenyl)propane-1-sulfonamide
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C14H16F2N6O3S
  1
1
IC50 = 438 nM
 Bioactivity Info 
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CP0449563
 Compound Info 
3-[[3-(2-cyanopropan-2-yl)benzoyl]amino]-2,6-difluoro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide
   Show/Hide
C25H19F2N5O2
  1
1
IC50 = 440 nM
 Bioactivity Info 
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CP0189063
 Compound Info 
N-[2,4-difluoro-3-(2-methyl-1-oxo-2,6-naphthyridin-3-yl)phenyl]propane-1-sulfonamide
   Show/Hide
C18H17F2N3O3S
  1
1
IC50 = 445 nM
 Bioactivity Info 
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CP0069735
 Compound Info 
N-[3-(8-bromo-2,6-naphthyridin-3-yl)-2,4-difluorophenyl]propane-1-sulfonamide
   Show/Hide
C17H14BrF2N3O2S
  1
1
IC50 = 469 nM
 Bioactivity Info 
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CP0392016
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-pyrazolo[1,5-a]pyrimidin-6-ylbenzamide
   Show/Hide
C16H15F2N5O3S
  1
1
IC50 = 488 nM
 Bioactivity Info 
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CP0513262
 Compound Info 
3-[[3-(2-cyanopropan-2-yl)benzoyl]amino]-N-(3-cyclopropyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluorobenzamide
   Show/Hide
C27H22F2N6O2
  1
1
IC50 = 520 nM
 Bioactivity Info 
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CP0482460
 Compound Info 
N-[2-(2-chlorophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18ClF2N5O3S
  1
1
IC50 = 557 nM
 Bioactivity Info 
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CP0482633
 Compound Info 
N-[3-[(3-benzyl-4-oxoquinazolin-6-yl)amino]-2-chloro-4-fluorophenyl]propane-1-sulfonamide
   Show/Hide
C24H22ClFN4O3S
  1
1
IC50 = 581 nM
 Bioactivity Info 
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CP0415686
 Compound Info 
N-[2-chloro-3-[ethyl-(3-methyl-4-oxoquinazolin-6-yl)amino]-4-fluorophenyl]propane-1-sulfonamide
   Show/Hide
C20H22ClFN4O3S
  1
1
IC50 = 603 nM
 Bioactivity Info 
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CP0198387
 Compound Info 
N-[3-(2-aminoquinazolin-6-yl)-2,4-difluorophenyl]propane-1-sulfonamide
   Show/Hide
C17H16F2N4O2S
  1
1
IC50 = 682 nM
 Bioactivity Info 
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CP0069711
 Compound Info 
N-[2,4-difluoro-3-(2,6-naphthyridin-3-yl)phenyl]propane-1-sulfonamide
   Show/Hide
C17H15F2N3O2S
  1
1
IC50 = 703 nM
 Bioactivity Info 
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CP0556325
 Compound Info 
2,6-difluoro-N-[2-(4-methylsulfonylphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C23H21F2N5O5S2
  1
1
IC50 = 728 nM
 Bioactivity Info 
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CP0382799
 Compound Info 
N-[2-chloro-4-fluoro-3-[(4-methoxyquinazolin-6-yl)amino]phenyl]propane-1-sulfonamide
   Show/Hide
C18H18ClFN4O3S
  1
1
IC50 = 733 nM
 Bioactivity Info 
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CP0482631
 Compound Info 
N-[2-chloro-4-fluoro-3-(quinoxalin-6-ylamino)phenyl]propane-1-sulfonamide
   Show/Hide
C17H16ClFN4O2S
  1
1
IC50 = 814 nM
 Bioactivity Info 
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CP0415682
 Compound Info 
N-[2-chloro-3-[[4-(dimethylamino)quinazolin-6-yl]amino]-4-fluorophenyl]propane-1-sulfonamide
   Show/Hide
C19H21ClFN5O2S
  1
1
IC50 = 878 nM
 Bioactivity Info 
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CP0482459
 Compound Info 
N-[2-(2-bromophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18BrF2N5O3S
  1
1
IC50 = 948 nM
 Bioactivity Info 
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CP0385594
 Compound Info 
2,6-difluoro-N-[2-(4-fluorophenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18F3N5O3S
  1
1
IC50 = 1052 nM
 Bioactivity Info 
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CP0465892
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-(2-pyridin-3-yl-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
   Show/Hide
C21H18F2N6O3S
  1
1
IC50 = 1125 nM
 Bioactivity Info 
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CP0230484
 Compound Info 
N-[2,4-difluoro-3-[2-oxo-1-(2-phenylethyl)-1,6-naphthyridin-3-yl]phenyl]propane-1-sulfonamide
   Show/Hide
C25H23F2N3O3S
  1
1
IC50 = 1163 nM
 Bioactivity Info 
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CP0391966
 Compound Info 
N-(2-tert-butyl-1H-imidazo[4,5-b]pyridin-6-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C20H23F2N5O3S
  1
1
IC50 = 1560 nM
 Bioactivity Info 
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CP0379674
 Compound Info 
2,6-difluoro-N-(2-methyl-1H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C17H17F2N5O3S
  1
1
IC50 = 1710 nM
 Bioactivity Info 
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CP0434573
 Compound Info 
2,6-difluoro-N-(2-propan-2-yl-1H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C19H21F2N5O3S
  1
1
IC50 = 1728 nM
 Bioactivity Info 
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CP0392022
 Compound Info 
N-(2-ethyl-1H-imidazo[4,5-b]pyridin-6-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C18H19F2N5O3S
  1
1
IC50 = 1768 nM
 Bioactivity Info 
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CP0507161
 Compound Info 
3-[[3-(2-cyanopropan-2-yl)benzoyl]amino]-2-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
   Show/Hide
C25H21FN6O3
  1
1
IC50 = 1800 nM
 Bioactivity Info 
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CP0408944
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-(2-pyridin-4-yl-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
   Show/Hide
C21H18F2N6O3S
  1
1
IC50 = 1909 nM
 Bioactivity Info 
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CP0372825
 Compound Info 
2,6-difluoro-N-(1H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C16H15F2N5O3S
  2
1
IC50 = 2386 nM
 Bioactivity Info 
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2
IC50 = 2400 nM
 Bioactivity Info 
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CP0262150
 Compound Info 
N-(6-aminopyridin-3-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C15H16F2N4O3S
  1
1
IC50 = 2400 nM
 Bioactivity Info 
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CP0465891
 Compound Info 
N-(2-cyclobutyl-1H-imidazo[4,5-b]pyridin-6-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C20H21F2N5O3S
  1
1
IC50 = 3332 nM
 Bioactivity Info 
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CP0928773
 Compound Info 
N-(2,4-Difluoro-3-(3-(6-(2-hydroxyethyl-amino)pyrimidin-4-yl)ureido)phenyl)propane-1-sulfonamide
   Show/Hide
C16H20F2N6O4S
  1
1
IC50 = 3400 nM
 Bioactivity Info 
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CP0480050
 Compound Info 
N-[2,4-difluoro-3-(quinolin-6-ylamino)phenyl]propane-1-sulfonamide
   Show/Hide
C18H17F2N3O2S
  1
1
IC50 = 6251 nM
 Bioactivity Info 
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CP0438366
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-pyridin-3-ylbenzamide
   Show/Hide
C15H15F2N3O3S
  1
1
IC50 = 6700 nM
 Bioactivity Info 
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CP0222856
 Compound Info 
N-[3-(2-aminoquinazolin-6-yl)-4-methylphenyl]propane-1-sulfonamide
   Show/Hide
C18H20N4O2S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0488508
 Compound Info 
3-(phenylcarbamoylamino)-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
   Show/Hide
C20H16N6O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0499360
 Compound Info 
3-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-1-N-phenylbenzene-1,3-dicarboxamide
   Show/Hide
C21H17N5O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0385595
 Compound Info 
2,6-difluoro-N-(2-piperidin-4-yl-1H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C21H24F2N6O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0465890
 Compound Info 
2,6-difluoro-N-(2-piperidin-3-yl-1H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C21H24F2N6O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0507158
 Compound Info 
3-benzamido-2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
   Show/Hide
C21H15F2N5O3
  1
1
IC50 > 12000 nM
 Bioactivity Info 
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Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0007711
 Compound Info 
(E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]-N'-propylprop-2-enehydrazide;2,2,2-trifluoroacetic acid
   Show/Hide
 C26H31F3N4O3  1
1
GI50 = 48.2 nM
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CP0036068
 Compound Info 
1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
   Show/Hide
 C24H16F6N6O  1
1
IC50 = 40 nM
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CP0064592
 Compound Info 
[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
   Show/Hide
 C47H51NO14  1
1
GI50 = 50 nM
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CP0148456
 Compound Info 
(2R)-2-amino-3-[(4-methoxyphenyl)-diphenylmethyl]sulfanylpropan-1-ol
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 C23H25NO2S  1
1
GI50 = 360 nM
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CP0383276
 Compound Info 
N-(4-methoxyphenyl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine
   Show/Hide
 C16H17N3O2  1
1
GI50 = 42.3 nM
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Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Lung)
Cell Line Name Organism Disease
T84
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
CFBE41o-
 Cell Line Info 
Homo sapiens (Human) Cystic fibrosis
A-549
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1975
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2073
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC827
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2228
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
A-427
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC44
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC1171
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
MR-5
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H522
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC366
 Cell Line Info 
Homo sapiens (Human) Lung adenosquamous carcinoma
NCI-H1581
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
DMS 53
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H1417
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
SW900
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H520
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1703
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H2286
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H358
 Cell Line Info 
Homo sapiens (Human) Minimally invasive lung adenocarcinoma
LLTC
 Cell Line Info 
Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
LLTC
 Cell Line Info 
Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
T8
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant mesothelioma
V79MZ
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79MZh11B2
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79MZh11B1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
Dede
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
39ER22
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
PS120
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHL
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
NP1
 Cell Line Info 
Homo sapiens (Human) -
IMR-90
 Cell Line Info 
Homo sapiens (Human) -
Hs 888.Lu
 Cell Line Info 
Homo sapiens (Human) -
BEAS-2B
 Cell Line Info 
Homo sapiens (Human) -
WI-38
 Cell Line Info 
Homo sapiens (Human) -
HL
 Cell Line Info 
Homo sapiens (Human) -
HFL1
 Cell Line Info 
Homo sapiens (Human) -
WI-38 VA13 subline 2RA
 Cell Line Info 
Homo sapiens (Human) -
HBE1
 Cell Line Info 
Homo sapiens (Human) -
16HBE14o-
 Cell Line Info 
Homo sapiens (Human) -
NAL1A clone C4E10
 Cell Line Info 
Mus musculus (Mouse) -
Mv1Lu
 Cell Line Info 
Neovison vison (American mink) -
RFL-6
 Cell Line Info 
Rattus norvegicus (Rat) -
PAC1
 Cell Line Info 
Rattus norvegicus (Rat) -
RLE
 Cell Line Info 
Rattus norvegicus (Rat) -