General Information of the Cell Line
Cell Line ID
CL000380
Cell Line Name
HCC827
Synonyms
HCC-827
HCC 827
HCC0827
Hamon Cancer Center 827
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2063
Tissue Information
Lung
Disease
Lung adenocarcinoma (NCIt: C3512)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00922, Epidermal growth factor receptor
Compound ID Compound Name Compound Formula
CP0852604
(R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
   Show/Hide
C25H24ClN7O2
 2
1
EC50 < 10 nM
   TI
   LI
   LO
   TS
2
GI50 = 15 nM
   TI
   LI
   LO
   TS
CP0033646
AZD-9291
   Show/Hide
C28H33N7O2
 1
1
GI50 = 1 nM
   TI
   LI
   LO
   TS
CP0857303
(R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
   Show/Hide
C25H26ClN7O2
 1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0081362
4-fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol
   Show/Hide
C27H23FN4O2
 1
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0002607
2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine
   Show/Hide
C19H24ClN7  1
1
GI50 = 12200 nM
   TI
   LI
   LO
   TS
CP0007280
2-N-(4-aminocyclohexyl)-6-N-(3-chlorophenyl)-9-(3-methylbutyl)purine-2,6-diamine
   Show/Hide
C22H30ClN7  1
1
GI50 = 10300 nM
   TI
   LI
   LO
   TS
CP0007350
2-N-(4-aminocyclohexyl)-6-N-(3,5-dimethoxyphenyl)-9-(3-methylbutyl)purine-2,6-diamine
   Show/Hide
C24H35N7O2  1
1
GI50 = 11200 nM
   TI
   LI
   LO
   TS
CP0012352
2-N-(4-aminocyclohexyl)-6-N-(2,4-dimethoxyphenyl)-9-(3-methylbutyl)purine-2,6-diamine
   Show/Hide
C24H35N7O2  1
1
GI50 = 32900 nM
   TI
   LI
   LO
   TS
CP0030740
1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea
   Show/Hide
C29H32N6O4S  1
1
GI50 > 5000 nM
   TI
   LI
   LO
   TS
CP0036082
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
   Show/Hide
C22H24ClFN4O3  1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0065286
AVL-301
   Show/Hide
C27H28F3N7O3  1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0120515
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one
   Show/Hide
C24H23FN4O3  1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0143525
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6,7-bis(3-morpholin-4-ylpropoxy)quinazolin-4-amine
   Show/Hide
C35H41ClFN5O5  1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0387091
3-[2-[(4-aminocyclohexyl)amino]-6-[2-(morpholin-4-ylmethyl)anilino]purin-9-yl]propan-1-ol
   Show/Hide
C25H36N8O2  1
1
GI50 > 40000 nM
   TI
   LI
   LO
   TS
CP0422009
N-[3-[[5-chloro-2-[4-(2-morpholin-4-ylethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
   Show/Hide
C25H27ClN6O3  1
1
IC50 = 43 nM
   TI
   LI
   LO
   TS
CP0435605
2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-[3-(morpholin-4-ylmethyl)phenyl]purine-2,6-diamine
   Show/Hide
C27H38N8O  1
1
GI50 = 1185 nM
   TI
   LI
   LO
   TS
CP0435607
2-N-(4-aminocyclohexyl)-6-N-[4-(4-benzylpiperazin-1-yl)phenyl]-9-cyclopentylpurine-2,6-diamine
   Show/Hide
C33H43N9  1
1
GI50 = 918 nM
   TI
   LI
   LO
   TS
CP0445117
2-[4-[[2-[(4-aminocyclohexyl)amino]-9-cyclopentylpurin-6-yl]amino]phenyl]phenol
   Show/Hide
C28H33N7O  1
1
GI50 = 2529 nM
   TI
   LI
   LO
   TS
CP0457419
N-[2-[[5-chloro-2-[4-(2-morpholin-4-ylethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
   Show/Hide
C25H27ClN6O3  1
1
IC50 = 524 nM
   TI
   LI
   LO
   TS
CP0458046
2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-[4-(2-methoxyphenyl)phenyl]purine-2,6-diamine
   Show/Hide
C29H35N7O  1
1
GI50 = 2304 nM
   TI
   LI
   LO
   TS
CP0468604
2-N-(4-aminobutyl)-9-cyclopentyl-6-N-[4-(1,3-thiazol-2-yloxy)phenyl]purine-2,6-diamine
   Show/Hide
C23H28N8OS  1
1
GI50 = 6313 nM
   TI
   LI
   LO
   TS
CP0482235
3-[2-[(4-aminocyclohexyl)amino]-6-[4-(morpholin-4-ylmethyl)anilino]purin-9-yl]cyclopentan-1-ol
   Show/Hide
C27H38N8O2  1
1
GI50 = 801 nM
   TI
   LI
   LO
   TS
CP0482248
4-[[9-(3-hydroxypropyl)-6-[4-(morpholin-4-ylmethyl)anilino]purin-2-yl]amino]butan-1-ol
   Show/Hide
C23H33N7O3  1
1
GI50 = 10593 nM
   TI
   LI
   LO
   TS
CP0483891
N-[2-[[5-chloro-2-[4-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
   Show/Hide
C24H25ClN6O2  1
1
IC50 = 995 nM
   TI
   LI
   LO
   TS
CP0532070
2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-(6-thiophen-2-ylpyridin-3-yl)purine-2,6-diamine
   Show/Hide
C25H30N8S  1
1
GI50 = 652 nM
   TI
   LI
   LO
   TS
CP0542283
2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-(4-pyrimidin-2-yloxyphenyl)purine-2,6-diamine
   Show/Hide
C26H31N9O  1
1
GI50 = 2716 nM
   TI
   LI
   LO
   TS
CP0550689
2-N-(4-aminobutyl)-9-cyclopentyl-6-N-[2-(morpholin-4-ylmethyl)phenyl]purine-2,6-diamine
   Show/Hide
C25H36N8O  1
1
GI50 = 26276 nM
   TI
   LI
   LO
   TS
CP0557893
2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-[6-(4-methoxyphenyl)pyridin-3-yl]purine-2,6-diamine
   Show/Hide
C28H34N8O  1
1
GI50 = 581 nM
   TI
   LI
   LO
   TS
CP0560148
4-[[9-cyclopentyl-6-[4-(morpholin-4-ylmethyl)anilino]purin-2-yl]amino]butan-1-ol
   Show/Hide
C25H35N7O2  1
1
GI50 = 2506 nM
   TI
   LI
   LO
   TS
CP0570958
3-[2-(4-aminobutylamino)-6-[4-(4-benzylpiperazin-1-yl)anilino]purin-9-yl]cyclopentan-1-ol
   Show/Hide
C31H41N9O  1
1
GI50 = 2292 nM
   TI
   LI
   LO
   TS
CP0574730
4-[[6-[4-(4-benzylpiperazin-1-yl)anilino]-9-(3-hydroxypropyl)purin-2-yl]amino]butan-1-ol
   Show/Hide
C29H38N8O2  1
1
GI50 = 9798 nM
   TI
   LI
   LO
   TS
CP0575411
CHEMBL4576935
   Show/Hide
C27H38N8O  1
1
GI50 = 22151 nM
   TI
   LI
   LO
   TS
CP0575412
3-[2-(4-aminobutylamino)-6-[4-(4-benzylpiperazin-1-yl)anilino]purin-9-yl]propan-1-ol
   Show/Hide
C29H39N9O  1
1
GI50 = 6701 nM
   TI
   LI
   LO
   TS
CP0576088
CHEMBL4530087
   Show/Hide
C28H34N8O  1
1
GI50 = 638 nM
   TI
   LI
   LO
   TS
CP0871866
N-(5-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide
   Show/Hide
C29H36ClN7O4S  1
1
GI50 = 6.2 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Lung)
Cell Line Name Organism Disease
T84 Homo sapiens (Human) Colon adenocarcinoma
CFBE41o- Homo sapiens (Human) Cystic fibrosis
A-549 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1975 Homo sapiens (Human) Lung adenocarcinoma
NCI-H2073 Homo sapiens (Human) Lung adenocarcinoma
NCI-H2228 Homo sapiens (Human) Lung adenocarcinoma
A-427 Homo sapiens (Human) Lung adenocarcinoma
HCC44 Homo sapiens (Human) Lung adenocarcinoma
HCC1171 Homo sapiens (Human) Lung adenocarcinoma
MR-5 Homo sapiens (Human) Lung adenocarcinoma
NCI-H522 Homo sapiens (Human) Lung adenocarcinoma
HCC366 Homo sapiens (Human) Lung adenosquamous carcinoma
NCI-H1581 Homo sapiens (Human) Lung large cell carcinoma
DMS 53 Homo sapiens (Human) Lung small cell carcinoma
NCI-H1417 Homo sapiens (Human) Lung small cell carcinoma
SW900 Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H520 Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1703 Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H2286 Homo sapiens (Human) Lung squamous cell carcinoma
Malme-3M Homo sapiens (Human) Melanoma
NCI-H358 Homo sapiens (Human) Minimally invasive lung adenocarcinoma
LLTC Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
LLTC Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
T8 Rattus norvegicus (Rat) Rat malignant mesothelioma
V79MZ Cricetulus griseus (Chinese hamster) -
V79 Cricetulus griseus (Chinese hamster) -
V79MZh11B2 Cricetulus griseus (Chinese hamster) -
V79MZh11B1 Cricetulus griseus (Chinese hamster) -
Dede Cricetulus griseus (Chinese hamster) -
39ER22 Cricetulus griseus (Chinese hamster) -
PS120 Cricetulus griseus (Chinese hamster) -
CHL Cricetulus griseus (Chinese hamster) -
NP1 Homo sapiens (Human) -
IMR-90 Homo sapiens (Human) -
Hs 888.Lu Homo sapiens (Human) -
BEAS-2B Homo sapiens (Human) -
WI-38 Homo sapiens (Human) -
HL Homo sapiens (Human) -
HFL1 Homo sapiens (Human) -
WI-38 VA13 subline 2RA Homo sapiens (Human) -
HBE1 Homo sapiens (Human) -
16HBE14o- Homo sapiens (Human) -
NAL1A clone C4E10 Mus musculus (Mouse) -
Mv1Lu Neovison vison (American mink) -
RFL-6 Rattus norvegicus (Rat) -
PAC1 Rattus norvegicus (Rat) -
RLE Rattus norvegicus (Rat) -