General Information of the Cell Line
Cell Line ID
CL000964
Cell Line Name
NCI-H522
Synonyms
NCI.H522
H522
H-522
NCI-522
NCI522
NCIH522
Category
Cancer cell line
Organism
Homo sapiens (Human)
Tissue Information
Lung
Disease
Lung adenocarcinoma (NCIt: C3512)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00838, NAD(P)H dehydrogenase [quinone] 1
Compound ID Compound Name Compound Formula
CP0393115
3,7,8-trimethylbenzo[g][1]benzofuran-4,5-dione
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C15H12O3
 1
1
IC50 = 4800 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0007711
(E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]-N'-propylprop-2-enehydrazide;2,2,2-trifluoroacetic acid
   Show/Hide
C26H31F3N4O3  2
1
GI50 = 96.9 nM
   TI
   LI
   LO
   TS
2
LC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0086475
2-[(4-methoxyphenyl)-diphenylmethyl]sulfanylethanamine
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C22H23NOS  1
1
GI50 = 40 nM
   TI
   LI
   LO
   TS
CP0148456
(2R)-2-amino-3-[(4-methoxyphenyl)-diphenylmethyl]sulfanylpropan-1-ol
   Show/Hide
C23H25NO2S  1
1
GI50 = 220 nM
   TI
   LI
   LO
   TS
CP0176598
N-[4-[2-[(2S,3S,5R)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-1,3-dithian-2-yl]phenyl]-N'-hydroxyoctanediamide
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C34H52N4O7S2Si  1
1
GI50 = 2691.53 nM
   TI
   LI
   LO
   TS
CP0370065
5-(4-chlorophenyl)-2-(4-methoxyphenyl)-[1,3]thiazolo[3,2-b][1,2,4]triazole
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C17H12ClN3OS  1
1
LC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0404446
2-((2-methoxy-4-(4-(pyrrolidin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
   Show/Hide
C30H35N7O3  1
1
EC50 = 950 nM
   TI
   LI
   LO
   TS
CP0421570
N-(5-methoxynaphthalen-2-yl)-N,2-dimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
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C20H21N3O  1
1
GI50 < 10 nM
   TI
   LI
   LO
   TS
CP0451721
(1S,7R,10S,16E,21R)-7-benzyl-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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C26H34N4O6S2  1
1
GI50 = 0.72 nM
   TI
   LI
   LO
   TS
CP0504740
4-(6-methoxy-3,4-dihydro-2H-quinolin-1-yl)-2,6-dimethylfuro[2,3-d]pyrimidine
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C18H19N3O2  1
1
GI50 < 10 nM
   TI
   LI
   LO
   TS
CP0557086
(1S,7S,10S,16E,21R)-7-benzyl-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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C26H34N4O6S2  1
1
GI50 = 200 nM
   TI
   LI
   LO
   TS
CP0565042
(1S,7S,10S,16E,21R)-7-methyl-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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C20H30N4O6S2  1
1
GI50 = 1700 nM
   TI
   LI
   LO
   TS
CP0897293
1-(7-Benzyl-2-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline hydrochloride
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C24H25ClN4O  1
1
GI50 = 316 nM
   TI
   LI
   LO
   TS
CP0906523
7-Benzyl-N-(4-methoxyphenyl)-N,2,5-trimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine hydrochloride
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C23H25ClN4O  1
1
GI50 = 23.9 nM
   TI
   LI
   LO
   TS
CP0911977
N-(4-Methoxyphenyl)-N,2-dimethyl-6,7-dihydro-5H-cyclopenta-[d]pyrimidin-4-aminium Chloride
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C16H20ClN3O  1
1
GI50 < 10 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Lung)
Cell Line Name Organism Disease
T84 Homo sapiens (Human) Colon adenocarcinoma
CFBE41o- Homo sapiens (Human) Cystic fibrosis
A-549 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1975 Homo sapiens (Human) Lung adenocarcinoma
NCI-H2073 Homo sapiens (Human) Lung adenocarcinoma
HCC827 Homo sapiens (Human) Lung adenocarcinoma
NCI-H2228 Homo sapiens (Human) Lung adenocarcinoma
A-427 Homo sapiens (Human) Lung adenocarcinoma
HCC44 Homo sapiens (Human) Lung adenocarcinoma
HCC1171 Homo sapiens (Human) Lung adenocarcinoma
MR-5 Homo sapiens (Human) Lung adenocarcinoma
HCC366 Homo sapiens (Human) Lung adenosquamous carcinoma
NCI-H1581 Homo sapiens (Human) Lung large cell carcinoma
DMS 53 Homo sapiens (Human) Lung small cell carcinoma
NCI-H1417 Homo sapiens (Human) Lung small cell carcinoma
SW900 Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H520 Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1703 Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H2286 Homo sapiens (Human) Lung squamous cell carcinoma
Malme-3M Homo sapiens (Human) Melanoma
NCI-H358 Homo sapiens (Human) Minimally invasive lung adenocarcinoma
LLTC Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
LLTC Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
T8 Rattus norvegicus (Rat) Rat malignant mesothelioma
V79MZ Cricetulus griseus (Chinese hamster) -
V79 Cricetulus griseus (Chinese hamster) -
V79MZh11B2 Cricetulus griseus (Chinese hamster) -
V79MZh11B1 Cricetulus griseus (Chinese hamster) -
Dede Cricetulus griseus (Chinese hamster) -
39ER22 Cricetulus griseus (Chinese hamster) -
PS120 Cricetulus griseus (Chinese hamster) -
CHL Cricetulus griseus (Chinese hamster) -
NP1 Homo sapiens (Human) -
IMR-90 Homo sapiens (Human) -
Hs 888.Lu Homo sapiens (Human) -
BEAS-2B Homo sapiens (Human) -
WI-38 Homo sapiens (Human) -
HL Homo sapiens (Human) -
HFL1 Homo sapiens (Human) -
WI-38 VA13 subline 2RA Homo sapiens (Human) -
HBE1 Homo sapiens (Human) -
16HBE14o- Homo sapiens (Human) -
NAL1A clone C4E10 Mus musculus (Mouse) -
Mv1Lu Neovison vison (American mink) -
RFL-6 Rattus norvegicus (Rat) -
PAC1 Rattus norvegicus (Rat) -
RLE Rattus norvegicus (Rat) -