| Compound ID |
Compound Name |
Compound Formula |
|
CP0544160
|
1-(2-chloro-6-ethoxypyridin-4-yl)-3-[[5-(1,3-dimethylpyrazol-4-yl)-4-methylpyridin-2-yl]methyl]urea
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|
C20H23ClN6O2
|
1
|
| 1 |
IC50 = 0.032 nM
|
|
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CP0559221
|
1-(3,5-dichlorophenyl)-3-[[5-(1,3-dimethylpyrazol-4-yl)-4-methylpyridin-2-yl]methyl]urea
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|
C19H19Cl2N5O
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
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CP0551199
|
5,6-dichloro-N-[[5-(1,3-dimethylpyrazol-4-yl)-4-methylpyridin-2-yl]methyl]-1H-benzimidazol-2-amine
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|
C19H18Cl2N6
|
1
|
| 1 |
IC50 = 0.43 nM
|
|
|
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CP0551200
|
4,6-dichloro-N-[[5-(1,3-dimethylpyrazol-4-yl)-4-methylpyridin-2-yl]methyl]-1H-indole-2-carboxamide
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|
C21H19Cl2N5O
|
1
|
| 1 |
IC50 = 0.61 nM
|
|
|
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CP0533873
|
1-(2,6-dichloropyridin-4-yl)-3-[[5-(1,3-dimethylpyrazol-4-yl)-4-methylpyridin-2-yl]methyl]urea
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|
C18H18Cl2N6O
|
1
|
| 1 |
IC50 = 0.77 nM
|
|
|
|
CP0544159
|
4,6-dichloro-N-[[5-(1,3-dimethylpyrazol-4-yl)-4-methylpyridin-2-yl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
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|
C20H18Cl2N6O
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
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CP0532870
|
2-[1-[[7-chloro-6-(cyclopropylmethoxy)imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxocinnolin-3-yl]propanoic acid
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|
C23H21ClN4O4
|
2
|
| 1 |
IC50 = 1.3 nM
|
|
|
| 2 |
IC50 = 15 nM
|
|
|
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CP0576517
|
(2S)-2-[1-[[7-chloro-6-(cyclopropylmethoxy)imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxocinnolin-3-yl]propanoic acid
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|
C23H21ClN4O4
|
2
|
| 1 |
IC50 = 2.1 nM
|
|
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| 2 |
IC50 = 19 nM
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|
|
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CP0546380
|
6-chloro-N-[[5-(1,3-dimethylpyrazol-4-yl)-4-methylpyridin-2-yl]methyl]-4-ethoxy-1H-imidazo[4,5-c]pyridin-2-amine
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|
C20H22ClN7O
|
1
|
| 1 |
IC50 = 2.25 nM
|
|
|
|
CP0549991
|
(2R)-2-[4-[[6-chloro-5-(cyclopropylmethoxy)indazol-2-yl]methyl]-1-oxophthalazin-2-yl]propanoic acid
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|
C23H21ClN4O4
|
2
|
| 1 |
IC50 = 3.5 nM
|
|
|
| 2 |
IC50 = 197 nM
|
|
|
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CP0532869
|
2-[1-[[7-chloro-6-(cyclopropylmethoxy)imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxocinnolin-3-yl]acetic acid
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|
C22H19ClN4O4
|
2
|
| 1 |
IC50 = 4.8 nM
|
|
|
| 2 |
IC50 = 60 nM
|
|
|
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CP0575747
|
2-[1-[[6-(cyclopropylmethoxy)-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxocinnolin-3-yl]propanoic acid
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|
C24H21F3N4O4
|
2
|
| 1 |
IC50 = 5 nM
|
|
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| 2 |
IC50 = 56 nM
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|
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CP0534011
|
2-[1-[[7-chloro-6-(cyclopropylmethoxy)imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxocinnolin-3-yl]butanoic acid
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|
C24H23ClN4O4
|
2
|
| 1 |
IC50 = 5.6 nM
|
|
|
| 2 |
IC50 = 25 nM
|
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|
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CP0528044
|
2-[4-[[7-chloro-6-(cyclopropylmethoxy)imidazo[1,2-a]pyridin-2-yl]methyl]-1-oxophthalazin-2-yl]acetic acid
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|
C22H19ClN4O4
|
2
|
| 1 |
IC50 = 7.6 nM
|
|
|
| 2 |
IC50 = 275 nM
|
|
|
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CP0532872
|
2-[4-[[6-chloro-5-(cyclopropylmethoxy)indazol-2-yl]methyl]-1-oxophthalazin-2-yl]acetic acid
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|
C22H19ClN4O4
|
2
|
| 1 |
IC50 = 8.1 nM
|
|
|
| 2 |
IC50 = 647 nM
|
|
|
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CP0422752
|
1-(6-chloro-2-ethoxy-3-methylpyridin-4-yl)-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
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|
C20H21ClF3N7O2
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 32000 nM
|
|
|
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CP0564519
|
1-(2-ethoxy-3,6-dimethylpyridin-4-yl)-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
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|
C21H24F3N7O2
|
2
|
| 1 |
IC50 = 16 nM
|
|
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| 2 |
IC50 = 49000 nM
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|
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CP0547058
|
1-(2-chloro-6-ethoxypyridin-4-yl)-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
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|
C19H19ClF3N7O2
|
2
|
| 1 |
IC50 = 20 nM
|
|
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| 2 |
IC50 = 45000 nM
|
|
|
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CP0549992
|
2-[1-[[7-chloro-6-(cyclopropylmethoxy)imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxocinnolin-3-yl]-2-methylpropanoic acid
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|
C24H23ClN4O4
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 361 nM
|
|
|
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CP0547064
|
1-(2-chloro-6-ethoxypyridin-4-yl)-3-[[4-methyl-5-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridin-2-yl]methyl]urea
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|
C20H20ClF3N6O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
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CP0534010
|
2-[4-[(6-chloro-5-ethoxyindazol-2-yl)methyl]-1-oxophthalazin-2-yl]acetic acid
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|
C20H17ClN4O4
|
2
|
| 1 |
IC50 = 23 nM
|
|
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| 2 |
IC50 = 1620 nM
|
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|
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CP0559220
|
1-(6-cyano-2-ethoxy-3-methylpyridin-4-yl)-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
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|
C21H21F3N8O2
|
2
|
| 1 |
IC50 = 24 nM
|
|
|
| 2 |
IC50 = 17000 nM
|
|
|
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CP0533837
|
1-(3-chloro-2-ethoxy-6-methylpyridin-4-yl)-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
Show/Hide
|
C20H21ClF3N7O2
|
2
|
| 1 |
IC50 = 26 nM
|
|
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| 2 |
IC50 = 49000 nM
|
|
|
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CP0555282
|
1-[1-[[7-chloro-6-(cyclopropylmethoxy)imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxocinnolin-3-yl]cyclopropane-1-carboxylic acid
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|
C24H21ClN4O4
|
2
|
| 1 |
IC50 = 28 nM
|
|
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| 2 |
IC50 = 304 nM
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CP0546378
|
1-[2-ethoxy-6-(trifluoromethyl)pyridin-4-yl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
Show/Hide
|
C20H19F6N7O2
|
2
|
| 1 |
IC50 = 29 nM
|
|
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| 2 |
IC50 = 87000 nM
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CP0418623
|
1-(2-cyano-6-ethoxypyridin-4-yl)-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
Show/Hide
|
C20H19F3N8O2
|
2
|
| 1 |
IC50 = 35 nM
|
|
|
| 2 |
IC50 = 67000 nM
|
|
|
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CP0557976
|
1-[2-chloro-6-(2,2-difluoroethoxy)pyridin-4-yl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
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|
C19H17ClF5N7O2
|
2
|
| 1 |
IC50 = 36 nM
|
|
|
| 2 |
IC50 = 71000 nM
|
|
|
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CP0422755
|
1-[[5-[(1,3-dimethylpyrazol-4-yl)amino]-4-methylpyridin-2-yl]methyl]-3-[2-ethoxy-6-(trifluoromethyl)pyridin-4-yl]urea
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|
C21H24F3N7O2
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
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CP0532873
|
2-[1-[[7-chloro-6-(cyclopropylmethoxy)imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxocinnolin-3-yl]-2-methoxyacetic acid
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|
C23H21ClN4O5
|
2
|
| 1 |
IC50 = 94 nM
|
|
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| 2 |
IC50 = 217 nM
|
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CP0471276
|
1-(2-chloro-6-ethoxypyridin-4-yl)-3-[[5-(2,6-dimethylmorpholin-4-yl)-4-methylpyridin-2-yl]methyl]urea
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|
C21H28ClN5O3
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
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CP0471266
|
1-[2-(2-hydroxyethoxy)-3-methyl-6-(trifluoromethyl)pyridin-4-yl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
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|
C21H21F6N7O3
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
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CP0534009
|
(2R)-2-[1-[[7-chloro-6-(cyclopropylmethoxy)imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxocinnolin-3-yl]propanoic acid
Show/Hide
|
C23H21ClN4O4
|
2
|
| 1 |
IC50 = 182 nM
|
|
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| 2 |
IC50 = 3180 nM
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CP0533834
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1-(2-ethoxy-6-methylpyridin-4-yl)-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
Show/Hide
|
C20H22F3N7O2
|
1
|
| 1 |
IC50 = 242 nM
|
|
|
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CP0533835
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1-[2-chloro-6-(2-methoxyethoxy)pyridin-4-yl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
Show/Hide
|
C20H21ClF3N7O3
|
1
|
| 1 |
IC50 = 640 nM
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|
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CP0546377
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1-[2-(2-hydroxyethoxy)-6-(trifluoromethyl)pyridin-4-yl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
Show/Hide
|
C20H19F6N7O3
|
1
|
| 1 |
IC50 = 704 nM
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CP0551198
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1-[2-[2-(dimethylamino)ethoxy]-6-(trifluoromethyl)pyridin-4-yl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
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|
C22H24F6N8O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
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CP0533836
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1-[2-(2,3-dihydroxypropoxy)-6-(trifluoromethyl)pyridin-4-yl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
Show/Hide
|
C21H21F6N7O4
|
1
|
| 1 |
IC50 > 11000 nM
|
|
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CP0546381
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1-(3-cyano-2-ethoxy-6-methylpyridin-4-yl)-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
Show/Hide
|
C21H21F3N8O2
|
1
|
| 1 |
IC50 > 20000 nM
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CP0422754
|
2,6-dichloro-N-[[5-(1,3-dimethylpyrazol-4-yl)-4-methylpyridin-2-yl]methyl]pyridine-4-carboxamide
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|
C18H17Cl2N5O
|
1
|
| 1 |
IC50 > 100 nM
|
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