General Information of the Cell Line
Cell Line ID
CL000268
Cell Line Name
NCI-H358
Synonyms
H358
H-358
NCIH358
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1559
Tissue Information
Lung
Disease
Minimally invasive lung adenocarcinoma (NCIt: C2923)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT03462, GTPase KRas
 Protein Info 
Compound ID Compound Name Compound Formula
CP0534196
 Compound Info 
2-[(2S)-4-[7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
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C33H39N7O2
  1
1
IC50 = 1 nM
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CP0535104
 Compound Info 
2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
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C32H36ClN7O2
  1
1
IC50 = 1 nM
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CP0473024
 Compound Info 
2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-[(E)-4-fluorobut-2-enoyl]piperazin-2-yl]acetonitrile
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C33H37ClFN7O2
  1
1
IC50 = 3 nM
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CP0534195
 Compound Info 
2-[(2S)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[8-(trifluoromethyl)naphthalen-1-yl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
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C33H36F3N7O2
  1
1
IC50 = 4 nM
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CP0535103
 Compound Info 
2-[(2S)-4-[7-(8-ethylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
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C34H41N7O2
  1
1
IC50 = 6 nM
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CP0570224
 Compound Info 
2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-[(E)-4-methoxybut-2-enoyl]piperazin-2-yl]acetonitrile
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C34H40ClN7O3
  1
1
IC50 = 9 nM
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CP0460810
 Compound Info 
2-[(2S)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
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C32H37N7O2
  1
1
IC50 = 10 nM
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CP0552434
 Compound Info 
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-4-[(3S)-3-(cyanomethyl)-4-prop-2-enoylpiperazin-1-yl]-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-2-oxo-1,8-naphthyridine-3-carbonitrile
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C33H28Cl3FN8O2
  1
1
IC50 = 12.25 nM
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CP0015072
 Compound Info 
Adagrasib
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C32H35ClFN7O2
  1
1
IC50 = 14 nM
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CP0473021
 Compound Info 
2-[4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
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C32H37N7O2
  1
1
IC50 = 14 nM
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CP0444489
 Compound Info 
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-4-[3-(cyanomethyl)-4-prop-2-enoylpiperazin-1-yl]-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-2-oxo-1,8-naphthyridine-3-carbonitrile
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C33H28Cl3FN8O2
  1
1
IC50 = 14.92 nM
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CP0444490
 Compound Info 
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-1-[4,6-di(propan-2-yl)pyrimidin-5-yl]-2-oxo-4-(4-prop-2-enoylpiperazin-1-yl)-1,8-naphthyridine-3-carbonitrile
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C32H30Cl3FN8O2
  1
1
IC50 = 18.51 nM
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CP0570618
 Compound Info 
7-(2-amino-6-fluorophenyl)-6-chloro-1-[4,6-di(propan-2-yl)pyrimidin-5-yl]-2-oxo-4-(4-prop-2-enoylpiperazin-1-yl)-1,8-naphthyridine-3-carbonitrile
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C32H32ClFN8O2
  1
1
IC50 = 20.1 nM
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CP0416375
 Compound Info 
2-[(2S)-4-[7-(8-methoxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
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C33H39N7O3
  1
1
IC50 = 22 nM
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CP0533768
 Compound Info 
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-oxo-1,8-naphthyridine-3-carbonitrile
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C32H29Cl3FN7O2
  1
1
IC50 = 28.8 nM
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CP0563420
 Compound Info 
6-chloro-7-(2-fluorophenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-2-oxo-4-(4-prop-2-enoylpiperazin-1-yl)-1,8-naphthyridine-3-carbonitrile
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C31H28ClFN6O2
  1
1
IC50 = 29.9 nM
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CP0232483
 Compound Info 
6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one
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C30H30F2N6O3
  1
1
IC50 = 30 nM
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CP0533767
 Compound Info 
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-4-[(3S,5R)-3,5-dimethyl-4-prop-2-enoylpiperazin-1-yl]-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-2-oxo-1,8-naphthyridine-3-carbonitrile
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C33H31Cl3FN7O2
  1
1
IC50 = 38.11 nM
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CP0559840
 Compound Info 
8-[4-[(3S)-3-(cyanomethyl)-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]naphthalene-1-carbonitrile
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C33H36N8O2
  1
1
IC50 = 64 nM
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CP0349547
 Compound Info 
1-[4-[7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C30H36N6O3
  2
1
IC50 = 70 nM
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2
IC50 = 142 nM
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CP0211364
 Compound Info 
1-[4-[(6R,7R)-7-(5-chloro-6-methyl-1H-indazol-4-yl)-2-[3-(dimethylamino)azetidin-1-yl]-6-methyl-5,6,7,8-tetrahydroquinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C29H37ClN8O
  1
1
IC50 = 116 nM
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CP0356252
 Compound Info 
1-[4-[(6R,7R)-6-methyl-7-(5-methyl-1H-indazol-4-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C30H39N7O2
  1
1
IC50 = 129 nM
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CP0945004
 Compound Info 
(S)-1-(4-(7-(5,6-Dimethyl-1H-indazol-4-yl)-2-((1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one
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C29H38N8O2
  1
1
IC50 = 254 nM
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CP0903575
 Compound Info 
(S)-1-(4-(2-((1-Methylpyrrolidin-2-yl)methoxy)-7-(5-(trifluoromethyl)-1H-indazol-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one
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C28H33F3N8O2
  1
1
IC50 = 351 nM
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CP0230698
 Compound Info 
1-[4-[(6R,7R)-7-(5-chloro-1H-indazol-4-yl)-2-[3-(dimethylamino)azetidin-1-yl]-6-methyl-5,6,7,8-tetrahydroquinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C28H35ClN8O
  1
1
IC50 = 395 nM
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CP0469455
 Compound Info 
1-[4-[(6R,7R)-2-[3-(dimethylamino)propoxy]-6-methyl-7-(5-methyl-1H-indazol-4-yl)-5,6,7,8-tetrahydroquinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C29H39N7O2
  1
1
IC50 = 468 nM
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CP0349546
 Compound Info 
1-[4-[2-[(2S)-1-(dimethylamino)propan-2-yl]oxy-7-(3-hydroxynaphthalen-1-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C29H36N6O3
  1
1
IC50 = 540 nM
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CP0508163
 Compound Info 
1-[4-[(6R,7R)-6-methyl-7-(5-methyl-1H-indazol-4-yl)-5,6,7,8-tetrahydroquinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C24H28N6O
  1
1
IC50 = 780 nM
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CP0520941
 Compound Info 
2-[(2R)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile
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C32H37N7O2
  1
1
IC50 = 1020 nM
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CP0903594
 Compound Info 
(S)-1-(4-(7-(5-Ethyl-1H-indazol-4-yl)-2-((1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one
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C29H38N8O2
  1
1
IC50 = 1080 nM
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CP0953363
 Compound Info 
(S)-1-(4-(7-(5-Isopropyl-1H-indazol-4-yl)-2-((1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one
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C30H40N8O2
  1
1
IC50 = 1180 nM
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CP0306601
 Compound Info 
1-[4-[2-[3-(dimethylamino)propoxy]-7-(3-hydroxynaphthalen-1-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C29H36N6O3
  1
1
IC50 = 1500 nM
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CP0903593
 Compound Info 
(S)-1-(4-(7-(5-Methyl-1H-indazol-4-yl)-2-((1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one
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C28H36N8O2
  1
1
IC50 = 1500 nM
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CP0147091
 Compound Info 
1-[4-[2-[2-(dimethylamino)ethoxy]-7-(3-hydroxynaphthalen-1-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C28H34N6O3
  1
1
IC50 = 1900 nM
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CP0473101
 Compound Info 
2-[1-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-4-prop-2-enoylpiperazin-2-yl]acetonitrile
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C32H37N7O2
  1
1
IC50 = 3320 nM
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CP0570223
 Compound Info 
1-[4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C30H36N6O2
  1
1
IC50 = 4400 nM
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CP0460809
 Compound Info 
1-[3-(hydroxymethyl)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C31H38N6O3
  1
1
IC50 = 4530 nM
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CP0517563
 Compound Info 
1-[2-(hydroxymethyl)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C31H38N6O3
  1
1
IC50 = 4630 nM
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CP0559839
 Compound Info 
1-[3-(2-hydroxyethyl)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C32H40N6O3
  1
1
IC50 = 4840 nM
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CP0141410
 Compound Info 
1-[4-[7-(3-hydroxynaphthalen-1-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C24H25N5O2
  1
1
IC50 = 7600 nM
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CP0127618
 Compound Info 
1-[4-[7-(7-hydroxynaphthalen-1-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C24H25N5O2
  1
1
IC50 > 16000 nM
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CP0178858
 Compound Info 
1-[4-(7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl]prop-2-en-1-one
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C24H25N5O
  1
1
IC50 > 16000 nM
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CP0188599
 Compound Info 
1-[4-[7-(5-methyl-1H-indazol-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C22H25N7O
  1
1
IC50 > 16000 nM
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CP0306600
 Compound Info 
1-[4-[7-(2-fluoro-6-hydroxyphenyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C20H22FN5O2
  1
1
IC50 > 16000 nM
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CP0417487
 Compound Info 
1-[4-[7-(2-fluoro-5-hydroxyphenyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C20H22FN5O2
  1
1
IC50 > 16000 nM
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CP0473023
 Compound Info 
2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-methoxyprop-2-enoyl)piperazin-2-yl]acetonitrile
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C33H38ClN7O3
  1
1
IC50 > 5000 nM
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CP0524392
 Compound Info 
1-[2-(2-hydroxyethyl)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C32H40N6O3
  1
1
IC50 > 5000 nM
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Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0158116
 Compound Info 
4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl}-amino)-7-[(1E)-4-(4-ethylpiperazin-1-yl)but-1-enyl]quinoline-3-carbonitrile
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 C30H32ClN7S  1
1
IC50 = 50 nM
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CP0302610
 Compound Info 
N-cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-[(1,1,1-trifluoro-2-methylpropan-2-yl)amino]imidazo[1,2-b]pyridazin-3-yl]benzamide
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 C26H31F3N6O2  1
1
IC50 = 320 nM
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CP0355547
 Compound Info 
(7S,10S,13R,16S,19R,22S,25S,28R,31S,34S,37R)-N-[(2S)-5-amino-1-[[(2R)-1-[[(2S)-1-[[(2R)-1-amino-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]-31-(2-amino-2-oxoethyl)-16-(3-amino-3-oxopropyl)-19-benzyl-10,13-bis(3-carbamimidamidopropyl)-34-(hydroxymethyl)-28,37-bis(naphthalen-2-ylmethyl)-4,9,12,15,18,21,24,27,30,33,36,39,42-tridecaoxo-25-phenyl-5,8,11,14,17,20,23,26,29,32,35,38,43-tridecazatricyclo[20.19.6.13,40]octatetraconta-1,3(48),40-triene-7-carboxamide
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 C108H138N30O21  1
1
EC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0444489
 Compound Info 
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-4-[3-(cyanomethyl)-4-prop-2-enoylpiperazin-1-yl]-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-2-oxo-1,8-naphthyridine-3-carbonitrile
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 C33H28Cl3FN8O2  1
1
IC50 = 35.58 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Lung)
Cell Line Name Organism Disease
T84
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
CFBE41o-
 Cell Line Info 
Homo sapiens (Human) Cystic fibrosis
A-549
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1975
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2073
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC827
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2228
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
A-427
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC44
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC1171
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
MR-5
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H522
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC366
 Cell Line Info 
Homo sapiens (Human) Lung adenosquamous carcinoma
NCI-H1581
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
DMS 53
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H1417
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
SW900
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H520
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1703
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H2286
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
Malme-3M
 Cell Line Info 
Homo sapiens (Human) Melanoma
LLTC
 Cell Line Info 
Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
LLTC
 Cell Line Info 
Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
T8
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant mesothelioma
V79MZ
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79MZh11B2
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79MZh11B1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
Dede
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
39ER22
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
PS120
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHL
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
NP1
 Cell Line Info 
Homo sapiens (Human) -
IMR-90
 Cell Line Info 
Homo sapiens (Human) -
Hs 888.Lu
 Cell Line Info 
Homo sapiens (Human) -
BEAS-2B
 Cell Line Info 
Homo sapiens (Human) -
WI-38
 Cell Line Info 
Homo sapiens (Human) -
HL
 Cell Line Info 
Homo sapiens (Human) -
HFL1
 Cell Line Info 
Homo sapiens (Human) -
WI-38 VA13 subline 2RA
 Cell Line Info 
Homo sapiens (Human) -
HBE1
 Cell Line Info 
Homo sapiens (Human) -
16HBE14o-
 Cell Line Info 
Homo sapiens (Human) -
NAL1A clone C4E10
 Cell Line Info 
Mus musculus (Mouse) -
Mv1Lu
 Cell Line Info 
Neovison vison (American mink) -
RFL-6
 Cell Line Info 
Rattus norvegicus (Rat) -
PAC1
 Cell Line Info 
Rattus norvegicus (Rat) -
RLE
 Cell Line Info 
Rattus norvegicus (Rat) -