General Information of the Compound
Compound ID
CP0517563
Compound Name
1-[2-(hydroxymethyl)-4-[2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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Structure
Formula
C31H38N6O3
Molecular Weight
542.684
Canonical SMILES
CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN(C(CO)C1)C(=O)C=C)c1cccc2ccccc12
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InChI
InChI=1S/C31H38N6O3/c1-3-29(39)37-17-16-36(18-24(37)20-38)30-26-13-15-35(28-12-6-9-22-8-4-5-11-25(22)28)19-27(26)32-31(33-30)40-21-23-10-7-14-34(23)2/h3-6,8-9,11-12,23-24,38H,1,7,10,13-21H2,2H3/t23-,24?/m0/s1
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InChIKey
DOBSCEYVFQNYML-UXMRNZNESA-N
Physicochemical Property
logP
2.861
Rotatable Bonds
7
Heavy Atom Count
40
Polar Areas
85.27
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156018543
ChEMBL ID
CHEMBL4643600
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03462, GTPase KRas
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000268 NCI-H358 Homo sapiens (Human)  1
1
IC50 = 4630 nM
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