Brief Information of the Compound and Protein
Compound Name
 Compound Info 
7-(2-amino-3,5-dichloro-6-fluorophenyl)-6-chloro-4-[(3S)-3-(cyanomethyl)-4-prop-2-enoylpiperazin-1-yl]-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-2-oxo-1,8-naphthyridine-3-carbonitrile
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Canonical SMILES
CC(C)c1nccc(C)c1-n1c2nc(c(Cl)cc2c(N2CCN([C@@H](CC#N)C2)C(=O)C=C)c(C#N)c1=O)-c1c(N)c(Cl)cc(Cl)c1F
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Compound Formula C33H28Cl3FN8O2
Compound Structure
Protein Name
 Protein Info 
GTPase KRas
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
P01116
Gene Name
KRAS
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000268 NCI-H358
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 12.25 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6.66 nM