General Information of the Cell Line
Cell Line ID
CL000070
Cell Line Name
RFL-6
Synonyms
RFL6
RFL 6
Rat Fetal Lung-6
Category
Finite cell line
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_2708
Tissue Information
Lung
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02485, cGMP-specific 3',5'-cyclic phosphodiesterase
 Protein Info 
Compound ID Compound Name Compound Formula
CP0381670
 Compound Info 
3-(2,3-Dihydro-benzofuran-5-yl)-2-(5-pyridin-2-yl-pyrimidin-2-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C28H21N5O2
  1
1
IC50 = 0.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0376603
 Compound Info 
3-Benzo[1,3]dioxol-5-yl-2-(4-imidazol-1-yl-phenyl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C27H20N4O3
  1
1
IC50 = 1.75 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0509609
 Compound Info 
2-(5-Bromo-pyrimidin-2-yl)-3-(2,3-dihydro-benzofuran-5-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C23H17BrN4O2
  1
1
IC50 = 1.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0554268
 Compound Info 
(R)-3-(2,3-Dihydro-benzofuran-5-yl)-2-(5-pyridin-2-yl-pyrimidin-2-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C28H21N5O2
  1
1
Ki = 0.019 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0381660
 Compound Info 
(R)-3-(2,3-Dihydro-benzofuran-5-yl)-2-pyridin-2-yl-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C24H19N3O2
  1
1
Ki = 0.12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0496997
 Compound Info 
2-[2,3'']Bipyridinyl-6''-yl-3-(2,3-dihydro-benzofuran-5-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C29H22N4O2
  1
1
Ki = 0.15 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0502715
 Compound Info 
2-[5-(3-Benzyl-3H-imidazol-4-yl)-pyridin-2-yl]-3-(2,3-dihydro-benzofuran-5-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C34H27N5O2
  1
1
Ki = 0.17 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0393282
 Compound Info 
3-Benzofuran-5-yl-2-(5-pyridin-2-yl-pyrimidin-2-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C28H19N5O2
  1
1
Ki = 0.19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0393260
 Compound Info 
3-(2,3-Dihydro-benzofuran-5-yl)-2-(5-pyridin-4-yl-pyrimidin-2-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C28H21N5O2
  1
1
Ki = 0.22 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0430100
 Compound Info 
2-[5-(3-Benzyl-2-methyl-3H-imidazol-4-yl)-pyrimidin-2-yl]-3-(2,3-dihydro-benzofuran-5-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C34H28N6O2
  1
1
Ki = 0.24 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0508226
 Compound Info 
3-(2,3-Dihydro-benzofuran-5-yl)-2-[5-(2,3-dimethyl-3H-imidazol-4-yl)-pyrimidin-2-yl]-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C28H24N6O2
  1
1
Ki = 0.24 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0496995
 Compound Info 
3-Benzo[1,3]dioxol-5-yl-2-(5-pyridin-3-yl-pyrimidin-2-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C27H19N5O3
  1
1
Ki = 0.29 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0500747
 Compound Info 
3-(2,3-Dihydro-benzofuran-5-yl)-2-[5-(3-methyl-3H-imidazol-4-yl)-pyridin-2-yl]-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C28H23N5O2
  1
1
Ki = 0.33 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0430102
 Compound Info 
3-(2,3-Dihydro-benzofuran-5-yl)-2-(5-pyridin-3-yl-pyrimidin-2-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C28H21N5O2
  1
1
Ki = 0.36 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0501159
 Compound Info 
3-(2,3-Dihydro-benzofuran-5-yl)-2-(4-imidazol-1-yl-phenyl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C28H22N4O2
  1
1
Ki = 0.51 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0244408
 Compound Info 
3-(2,3-Dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-on
   Show/Hide
C30H24N4O3
  1
1
Ki = 0.52 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0277224
 Compound Info 
2-{5-[4-(2-Diethylamino-ethoxy)-phenyl]-pyrimidin-2-yl}-3-(2,3-dihydro-benzofuran-5-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C35H35N5O3
  1
1
Ki = 0.53 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0497305
 Compound Info 
3-(2,3-Dihydro-benzofuran-5-yl)-2-pyridin-2-yl-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C24H19N3O2
  1
1
Ki = 0.65 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0010658
 Compound Info 
5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
   Show/Hide
C22H30N6O4S
  1
1
Ki = 1.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0000847
 Compound Info 
(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione
   Show/Hide
C22H19N3O4
  1
1
Ki = 5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0502519
 Compound Info 
2-[2,2'']Bipyridinyl-5-yl-3-(2,3-dihydro-benzofuran-5-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C29H22N4O2
  1
1
Ki = 6.43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Lung)
Cell Line Name Organism Disease
T84
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
CFBE41o-
 Cell Line Info 
Homo sapiens (Human) Cystic fibrosis
A-549
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1975
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2073
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC827
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2228
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
A-427
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC44
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC1171
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
MR-5
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H522
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC366
 Cell Line Info 
Homo sapiens (Human) Lung adenosquamous carcinoma
NCI-H1581
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
DMS 53
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H1417
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
SW900
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H520
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1703
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H2286
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
Malme-3M
 Cell Line Info 
Homo sapiens (Human) Melanoma
NCI-H358
 Cell Line Info 
Homo sapiens (Human) Minimally invasive lung adenocarcinoma
LLTC
 Cell Line Info 
Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
LLTC
 Cell Line Info 
Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
T8
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant mesothelioma
V79MZ
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79MZh11B2
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79MZh11B1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
Dede
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
39ER22
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
PS120
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHL
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
NP1
 Cell Line Info 
Homo sapiens (Human) -
IMR-90
 Cell Line Info 
Homo sapiens (Human) -
Hs 888.Lu
 Cell Line Info 
Homo sapiens (Human) -
BEAS-2B
 Cell Line Info 
Homo sapiens (Human) -
WI-38
 Cell Line Info 
Homo sapiens (Human) -
HL
 Cell Line Info 
Homo sapiens (Human) -
HFL1
 Cell Line Info 
Homo sapiens (Human) -
WI-38 VA13 subline 2RA
 Cell Line Info 
Homo sapiens (Human) -
HBE1
 Cell Line Info 
Homo sapiens (Human) -
16HBE14o-
 Cell Line Info 
Homo sapiens (Human) -
NAL1A clone C4E10
 Cell Line Info 
Mus musculus (Mouse) -
Mv1Lu
 Cell Line Info 
Neovison vison (American mink) -
PAC1
 Cell Line Info 
Rattus norvegicus (Rat) -
RLE
 Cell Line Info 
Rattus norvegicus (Rat) -