General Information of the Cell Line
Cell Line ID
CL000761
Cell Line Name
RLE
Synonyms
Rat Lung Epithelial
Category
Transformed cell line
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_LB71
Tissue Information
Lung
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT03393, P2X purinoceptor 3
 Protein Info 
Compound ID Compound Name Compound Formula
CP0126041
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[isoquinolin-3-ylmethyl(methyl)amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C26H31N7O2
  1
1
IC50 = 22 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0007475
 Compound Info 
2-(4-acetylpiperazin-1-yl)-6-propan-2-yl-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C25H29N7O2
  1
1
IC50 = 24 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0110947
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-(isoquinolin-3-ylmethylamino)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C25H29N7O2
  1
1
IC50 = 24 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0315753
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[[(1R)-1-(4-ethoxy-3-fluorophenyl)ethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C25H33FN6O3
  1
1
IC50 = 38 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0011363
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[[1-(4-chlorophenyl)-2-methylpropan-2-yl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C25H33ClN6O2
  1
1
IC50 = 61 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0315751
 Compound Info 
2-(4-acetylpiperazin-1-yl)-6-propan-2-yl-4-[[(1R)-1-[4-(trifluoromethoxy)phenyl]ethyl]amino]-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C24H29F3N6O3
  1
1
IC50 = 64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0548327
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[[2-methoxy-4-(trifluoromethoxy)phenyl]methylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C24H29F3N6O4
  1
1
IC50 = 67 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0525961
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[[(1R)-1-(4-ethoxyphenyl)ethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C25H34N6O3
  1
1
IC50 = 69 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0315752
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[[(1S)-1-(4-ethoxyphenyl)-2,2,2-trifluoroethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C25H31F3N6O3
  1
1
IC50 = 115 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0416718
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[[(1R)-1-(4-ethoxyphenyl)propyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C26H36N6O3
  1
1
IC50 = 212 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0524987
 Compound Info 
4-(benzhydrylamino)-2-(2-methoxyethylamino)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C25H29N5O2
  1
1
IC50 = 255 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0513883
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[[1-(4-chlorophenyl)cyclobutyl]methylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C26H33ClN6O2
  1
1
IC50 = 262 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380975
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-(benzhydrylamino)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C28H32N6O2
  1
1
IC50 = 268 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0339972
 Compound Info 
2-(4-acetylpiperazin-1-yl)-6-propan-2-yl-4-[[4-(trifluoromethoxy)phenyl]methylamino]-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C23H27F3N6O3
  1
1
IC50 = 324 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0524986
 Compound Info 
N-[1-[4-(benzhydrylamino)-7-oxo-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]acetamide
   Show/Hide
C28H32N6O2
  1
1
IC50 = 327 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0549411
 Compound Info 
4-(benzhydrylamino)-2-(4-methylsulfonylpiperazin-1-yl)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C27H32N6O3S
  1
1
IC50 = 398 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0488455
 Compound Info 
2-[4-[4-(benzhydrylamino)-7-oxo-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-2-yl]piperazin-1-yl]-N,N-dimethylacetamide
   Show/Hide
C30H37N7O2
  1
1
IC50 = 440 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0415757
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[2-(4-chlorophenyl)propylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C24H31ClN6O2
  1
1
IC50 = 441 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0525962
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[[(1R)-1-(6-ethoxy-5-fluoropyridin-3-yl)ethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C24H32FN7O3
  1
1
IC50 = 521 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0432177
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[[(1R)-1-(4-methylphenyl)ethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C24H32N6O2
  1
1
IC50 = 613 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0489265
 Compound Info 
4-(benzhydrylamino)-2-piperazin-1-yl-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C26H30N6O
  1
1
IC50 = 618 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0416717
 Compound Info 
2-(4-acetylpiperazin-1-yl)-6-propan-2-yl-4-[[4-(trifluoromethyl)phenyl]methylamino]-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C23H27F3N6O2
  1
1
IC50 = 1271 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0415756
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[2-(4-methylphenyl)ethylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C24H32N6O2
  1
1
IC50 = 1311 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0524985
 Compound Info 
4-(benzhydrylamino)-2-morpholin-4-yl-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C26H29N5O2
  1
1
IC50 = 1360 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0417232
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[2-(4-chlorophenyl)ethylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C23H29ClN6O2
  1
1
IC50 = 1665 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0475821
 Compound Info 
4-(benzhydrylamino)-2-(4-methylpiperazin-1-yl)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C27H32N6O
  1
1
IC50 = 1947 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0517547
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[[2-(4-chlorophenyl)-2-methylpropyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C25H33ClN6O2
  1
1
IC50 = 2057 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0110778
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C24H32N6O3
  1
1
IC50 = 2523 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0110777
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-[(4-chlorophenyl)methylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C22H27ClN6O2
  1
1
IC50 = 4214 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433242
 Compound Info 
4-(benzhydrylamino)-2-[4-[2-(dimethylamino)acetyl]piperazin-1-yl]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C30H37N7O2
  1
1
IC50 = 5689 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0549788
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-(2-phenylethylamino)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C23H30N6O2
  1
1
IC50 = 13950 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0489266
 Compound Info 
2-(4-acetylpiperazin-1-yl)-4-(benzylamino)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
   Show/Hide
C22H28N6O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Lung)
Cell Line Name Organism Disease
T84
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
CFBE41o-
 Cell Line Info 
Homo sapiens (Human) Cystic fibrosis
A-549
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1975
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2073
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC827
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2228
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
A-427
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC44
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC1171
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
MR-5
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H522
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC366
 Cell Line Info 
Homo sapiens (Human) Lung adenosquamous carcinoma
NCI-H1581
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
DMS 53
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H1417
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
SW900
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H520
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1703
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H2286
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
Malme-3M
 Cell Line Info 
Homo sapiens (Human) Melanoma
NCI-H358
 Cell Line Info 
Homo sapiens (Human) Minimally invasive lung adenocarcinoma
LLTC
 Cell Line Info 
Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
LLTC
 Cell Line Info 
Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
T8
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant mesothelioma
V79MZ
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79MZh11B2
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79MZh11B1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
Dede
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
39ER22
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
PS120
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHL
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
NP1
 Cell Line Info 
Homo sapiens (Human) -
IMR-90
 Cell Line Info 
Homo sapiens (Human) -
Hs 888.Lu
 Cell Line Info 
Homo sapiens (Human) -
BEAS-2B
 Cell Line Info 
Homo sapiens (Human) -
WI-38
 Cell Line Info 
Homo sapiens (Human) -
HL
 Cell Line Info 
Homo sapiens (Human) -
HFL1
 Cell Line Info 
Homo sapiens (Human) -
WI-38 VA13 subline 2RA
 Cell Line Info 
Homo sapiens (Human) -
HBE1
 Cell Line Info 
Homo sapiens (Human) -
16HBE14o-
 Cell Line Info 
Homo sapiens (Human) -
NAL1A clone C4E10
 Cell Line Info 
Mus musculus (Mouse) -
Mv1Lu
 Cell Line Info 
Neovison vison (American mink) -
RFL-6
 Cell Line Info 
Rattus norvegicus (Rat) -
PAC1
 Cell Line Info 
Rattus norvegicus (Rat) -