| Compound ID |
Compound Name |
Compound Formula |
|
CP0569305
|
2-[5-chloro-2-(2-methoxyanilino)pyrimidin-4-yl]-1'-prop-2-enoylspiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one
Show/Hide
|
C25H25ClN6O3
|
2
|
| 1 |
EC50 = 3.1 nM
|
|
|
| 2 |
EC50 = 277 nM
|
|
|
|
CP0509684
|
N-[2-[[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]methyl]phenyl]prop-2-enamide
Show/Hide
|
C30H31N9O
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0053637
|
(S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Show/Hide
|
C24H25ClFN5O3
|
4
|
| 1 |
EC50 = 7.5 nM
|
|
|
| 2 |
EC50 = 30 nM
|
|
|
| 3 |
IC50 = 23 nM
|
|
|
| 4 |
IC50 = 714 nM
|
|
|
|
CP0034107
|
2-[2-(2-propan-2-yloxyanilino)pyrimidin-4-yl]-1'-prop-2-enoylspiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one
Show/Hide
|
C27H30N6O3
|
2
|
| 1 |
EC50 = 8.8 nM
|
|
|
| 2 |
EC50 = 562 nM
|
|
|
|
CP0403145
|
N-[3-[2-[3-amino-6-[1-(1-ethylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C30H31N9O
|
1
|
| 1 |
EC50 = 9 nM
|
|
|
|
CP0445078
|
N-[3-[2-[3-amino-6-(1-methylpyrazol-4-yl)pyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C24H20N8O
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0852604
|
(R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C25H24ClN7O2
|
2
|
| 1 |
EC50 < 10 nM
|
|
|
| 2 |
GI50 = 5 nM
|
|
|
|
CP0466881
|
N-[3-[2-[3-amino-6-[1-(2-hydroxyethyl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C25H22N8O2
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0031490
|
2-[2-(2-methoxyanilino)-5-methylpyrimidin-4-yl]-1'-prop-2-enoylspiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one
Show/Hide
|
C26H28N6O3
|
2
|
| 1 |
EC50 = 12 nM
|
|
|
| 2 |
EC50 = 165 nM
|
|
|
|
CP0462444
|
N-[3-[2-[3-amino-6-[1-(1-propan-2-ylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C31H33N9O
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0472275
|
N-[3-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C29H29N9O
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0390865
|
N-[3-[2-[3-amino-6-[1-[1-[2-(dimethylamino)acetyl]piperidin-4-yl]pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C32H34N10O2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0474061
|
N-[3-[2-[3-amino-6-[1-[2-(4-methylpiperazin-1-yl)ethyl]pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C30H32N10O
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0466880
|
N-[3-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]imidazo[4,5-c]pyridin-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C28H28N10O
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0033646
|
AZD-9291
Show/Hide
|
C28H33N7O2
|
9
|
| 1 |
EC50 = 19 nM
|
|
|
| 2 |
EC50 = 57 nM
|
|
|
| 3 |
EC50 = 286 nM
|
|
|
| 4 |
GI50 = 5 nM
|
|
|
| 5 |
IC50 = 2.5 nM
|
|
|
| 6 |
IC50 = 15 nM
|
|
|
| 7 |
IC50 = 22 nM
|
|
|
| 8 |
IC50 = 30 nM
|
|
|
| 9 |
IC50 = 41 nM
|
|
|
|
CP0546212
|
N-[3-[2-[4-[4-[12-[[2-(1-adamantyl)acetyl]amino]dodecyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
Show/Hide
|
C52H70N8O4
|
1
|
| 1 |
EC50 = 20.1 nM
|
|
|
|
CP0386433
|
N-[3-[2-[6-[1-(1-acetylpiperidin-4-yl)pyrazol-4-yl]-3-aminopyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C30H29N9O2
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0386432
|
N-[3-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]-2-fluorophenyl]prop-2-enamide
Show/Hide
|
C29H28FN9O
|
1
|
| 1 |
EC50 = 23 nM
|
|
|
|
CP0556453
|
N-[3-[2-[3-amino-6-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C29H29N9O2
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0556454
|
N-[3-[2-[3-amino-6-[1-[1-(2-hydroxyacetyl)piperidin-4-yl]pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C30H29N9O3
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0033949
|
2-[2-(2-methoxyanilino)pyrimidin-4-yl]-1'-prop-2-enoylspiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one
Show/Hide
|
C25H26N6O3
|
2
|
| 1 |
EC50 = 40 nM
|
|
|
| 2 |
EC50 = 308 nM
|
|
|
|
CP0445081
|
N-[3-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]-4-fluorophenyl]prop-2-enamide
Show/Hide
|
C29H28FN9O
|
1
|
| 1 |
EC50 = 73 nM
|
|
|
|
CP0378734
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[5-(4-fluorophenyl)-1H-indazol-3-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C28H31FN6O2
|
2
|
| 1 |
EC50 = 100 nM
|
|
|
| 2 |
EC50 = 694 nM
|
|
|
|
CP0397862
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[6-(1-methylindol-3-yl)-1H-indazol-3-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C31H35N7O2
|
2
|
| 1 |
EC50 = 100 nM
|
|
|
| 2 |
EC50 = 417 nM
|
|
|
|
CP0065286
|
AVL-301
Show/Hide
|
C27H28F3N7O3
|
3
|
| 1 |
EC50 = 118 nM
|
|
|
| 2 |
IC50 = 4.1 nM
|
|
|
| 3 |
IC50 = 16 nM
|
|
|
|
CP0551613
|
N-[3-[2-[4-[4-[12-[[2-(1-adamantyl)acetyl]amino]dodecyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]-2-methylpropanamide
Show/Hide
|
C53H74N8O4
|
1
|
| 1 |
EC50 = 143.3 nM
|
|
|
|
CP0542298
|
N-[3-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]imidazo[4,5-c]pyridin-3-yl]phenyl]prop-2-enamide
Show/Hide
|
C28H28N10O
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0169994
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[6-(3-fluoroanilino)-1H-indazol-3-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C28H32FN7O2
|
1
|
| 1 |
EC50 = 191 nM
|
|
|
|
CP0390850
|
N-[3-[[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]methyl]phenyl]prop-2-enamide
Show/Hide
|
C30H31N9O
|
1
|
| 1 |
EC50 = 360 nM
|
|
|
|
CP0542299
|
N-[3-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]-N-methylprop-2-enamide
Show/Hide
|
C30H31N9O
|
1
|
| 1 |
EC50 = 390 nM
|
|
|
|
CP0497883
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[(6-pyridin-4-yl-1H-indazol-3-yl)amino]phenyl]prop-2-enamide
Show/Hide
|
C27H31N7O2
|
1
|
| 1 |
EC50 = 489 nM
|
|
|
|
CP0474062
|
N-[4-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C29H29N9O
|
1
|
| 1 |
EC50 = 550 nM
|
|
|
|
CP0546215
|
N-[3-[2-[4-[4-[12-[[2-(1-adamantyl)acetyl]amino]dodecyl]piperazin-1-yl]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]cyclopropanecarboxamide
Show/Hide
|
C53H72N8O4
|
1
|
| 1 |
EC50 = 578.6 nM
|
|
|
|
CP0378733
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[6-(3-fluorophenyl)-1H-indazol-3-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C28H31FN6O2
|
1
|
| 1 |
EC50 = 608 nM
|
|
|
|
CP0548778
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[(6-isoquinolin-4-yl-1H-indazol-3-yl)amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C31H33N7O2
|
1
|
| 1 |
EC50 = 632 nM
|
|
|
|
CP0410181
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[6-(4-fluorophenyl)-1H-indazol-3-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C28H31FN6O2
|
1
|
| 1 |
EC50 = 659 nM
|
|
|
|
CP0389770
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[(5-naphthalen-2-yl-1H-indazol-3-yl)amino]phenyl]prop-2-enamide
Show/Hide
|
C32H34N6O2
|
2
|
| 1 |
EC50 = 960 nM
|
|
|
| 2 |
EC50 = 1000 nM
|
|
|
|
CP0492071
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[(6-pyridin-3-yl-1H-indazol-3-yl)amino]phenyl]prop-2-enamide
Show/Hide
|
C27H31N7O2
|
1
|
| 1 |
EC50 = 1041 nM
|
|
|
|
CP0378732
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[6-[4-(dimethylamino)phenyl]-1H-indazol-3-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C30H37N7O2
|
1
|
| 1 |
EC50 = 1050 nM
|
|
|
|
CP0378731
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[(6-naphthalen-1-yl-1H-indazol-3-yl)amino]phenyl]prop-2-enamide
Show/Hide
|
C32H34N6O2
|
1
|
| 1 |
EC50 = 1102 nM
|
|
|
|
CP0476426
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[6-[3-(dimethylamino)phenyl]-1H-indazol-3-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C30H37N7O2
|
1
|
| 1 |
EC50 = 1321 nM
|
|
|
|
CP0403256
|
N-[5-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]-2-methoxyphenyl]prop-2-enamide
Show/Hide
|
C30H31N9O2
|
1
|
| 1 |
EC50 = 1340 nM
|
|
|
|
CP0547085
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[(6-naphthalen-2-yl-1H-indazol-3-yl)amino]phenyl]prop-2-enamide
Show/Hide
|
C32H34N6O2
|
1
|
| 1 |
EC50 = 1610 nM
|
|
|
|
CP0407740
|
N-[3-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]propyl]prop-2-enamide
Show/Hide
|
C26H31N9O
|
1
|
| 1 |
EC50 = 1710 nM
|
|
|
|
CP0386431
|
N-[4-[[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]methyl]phenyl]prop-2-enamide
Show/Hide
|
C30H31N9O
|
1
|
| 1 |
EC50 = 1780 nM
|
|
|
|
CP0544220
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[6-[3-(trifluoromethyl)phenyl]-1H-indazol-3-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C29H31F3N6O2
|
1
|
| 1 |
EC50 = 1856 nM
|
|
|
|
CP0476427
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[(5-naphthalen-1-yl-1H-indazol-3-yl)amino]phenyl]prop-2-enamide
Show/Hide
|
C32H34N6O2
|
1
|
| 1 |
EC50 = 2077 nM
|
|
|
|
CP0574100
|
1'-[3-(dimethylamino)prop-2-ynoyl]-2-[2-(2-methoxyanilino)pyrimidin-4-yl]spiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one
Show/Hide
|
C27H29N7O3
|
1
|
| 1 |
EC50 = 2180 nM
|
|
|
|
CP0275988
|
2-[2-(3-methoxyphenyl)pyrimidin-4-yl]-1'-prop-2-enoylspiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one
Show/Hide
|
C25H25N5O3
|
1
|
| 1 |
EC50 = 2550 nM
|
|
|
|
CP0441188
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-(1H-indazol-3-ylamino)-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C22H28N6O2
|
1
|
| 1 |
EC50 = 3527 nM
|
|
|
|
CP0547871
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-(1H-indazol-3-ylamino)phenyl]prop-2-enamide
Show/Hide
|
C21H26N6O
|
1
|
| 1 |
EC50 = 6926 nM
|
|
|
|
CP0033712
|
2-[2-(2-methoxyanilino)pyridin-4-yl]-1'-prop-2-enoylspiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one
Show/Hide
|
C26H27N5O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0036082
|
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Show/Hide
|
C22H24ClFN4O3
|
3
|
| 1 |
EC50 = 10733 nM
|
|
|
| 2 |
IC50 = 3300 nM
|
|
|
| 3 |
IC50 = 13980 nM
|
|
|
|
CP0566904
|
N-[2-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]ethyl]prop-2-enamide
Show/Hide
|
C25H29N9O
|
1
|
| 1 |
EC50 = 14900 nM
|
|
|
|
CP0468764
|
N-[3-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]-2-methylprop-2-enamide
Show/Hide
|
C30H31N9O
|
1
|
| 1 |
EC50 > 20000 nM
|
|
|
|
CP0468765
|
N-[3-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]acetamide
Show/Hide
|
C28H29N9O
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
|
CP0476424
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-(1H-indazol-3-ylamino)-4-methoxyphenyl]propanamide
Show/Hide
|
C22H30N6O2
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
|
CP0476425
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-(1H-indazol-3-ylamino)phenyl]propanamide
Show/Hide
|
C21H28N6O
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
|
CP0007430
|
IBRUTINIB
Show/Hide
|
C25H24N6O2
|
1
|
| 1 |
GI50 = 1200 nM
|
|
|
|
CP0857303
|
(R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Show/Hide
|
C25H26ClN7O2
|
1
|
| 1 |
GI50 = 3000 nM
|
|
|
|
CP0546825
|
(3S,4R)-3-fluoro-3-methyl-1-[4-[[8-[(2R,3S)-2-methyl-3-(methylsulfonylmethyl)azetidin-1-yl]-5-propan-2-ylisoquinolin-3-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
|
C28H37FN6O3S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0564476
|
BLU-945
Show/Hide
|
C28H37FN6O3S
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0316934
|
N-[7-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C25H25F3N4O2
|
1
|
| 1 |
IC50 = 1.39 nM
|
|
|
|
CP0145964
|
N-[1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methylbenzimidazol-2-yl]-2-(trifluoromethyl)pyridine-4-carboxamide
Show/Hide
|
C27H31F3N6O2
|
1
|
| 1 |
IC50 = 1.51 nM
|
|
|
|
CP0568877
|
(3S,4R)-3-fluoro-3-methyl-1-[4-[[8-[(2R,3S)-2-methyl-3-(methylsulfonylmethyl)azetidin-1-yl]-5-propan-2-yl-2,7-naphthyridin-3-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
|
C27H36FN7O3S
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0546833
|
(3S,4R)-3-ethyl-3-fluoro-1-[4-[[8-[(2R,3S)-2-methyl-3-(methylsulfonylmethyl)azetidin-1-yl]-5-propan-2-ylisoquinolin-3-yl]amino]pyrimidin-2-yl]piperidin-4-ol
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C29H39FN6O3S
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1
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| 1 |
IC50 = 1.8 nM
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CP0293062
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N-[1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methylbenzimidazol-2-yl]-2-methylpyridine-4-carboxamide
Show/Hide
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C27H34N6O2
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1
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| 1 |
IC50 = 2.11 nM
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CP0217163
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N-[1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methylbenzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Show/Hide
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C28H32F3N5O2
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1
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| 1 |
IC50 = 2.18 nM
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CP0568871
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(3R,4R)-5,5-difluoro-4-methoxy-1-[4-[[8-[(2R,3S)-2-methyl-3-(methylsulfonylmethyl)azetidin-1-yl]-5-propan-2-ylisoquinolin-3-yl]amino]pyrimidin-2-yl]piperidin-3-ol
Show/Hide
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C28H36F2N6O4S
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1
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| 1 |
IC50 = 2.6 nM
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CP0571685
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(3S,4R)-3-fluoro-3-methyl-1-[4-[[8-[3-(methylsulfonylmethyl)azetidin-1-yl]-5-propan-2-ylisoquinolin-3-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
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C27H35FN6O3S
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1
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| 1 |
IC50 = 2.7 nM
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CP0472536
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N-[3-[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
Show/Hide
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C28H29N7O3
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1
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| 1 |
IC50 = 3 nM
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CP0036058
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N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide
Show/Hide
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C24H25ClFN5O3
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1
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| 1 |
IC50 = 3 nM
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CP0545094
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(3S,4R)-3-fluoro-4-methyl-1-[4-[[8-[(2R,3S)-2-methyl-3-(methylsulfonylmethyl)azetidin-1-yl]-5-propan-2-ylisoquinolin-3-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
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C28H37FN6O3S
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1
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| 1 |
IC50 = 3.8 nM
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CP0055009
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N-[3-[2-[4-[2-(dimethylamino)ethoxy]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
Show/Hide
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C28H30N6O4
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1
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| 1 |
IC50 = 4 nM
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CP0203178
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N-[3-[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
Show/Hide
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C29H31N7O3
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1
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| 1 |
IC50 = 4 nM
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CP0511115
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N-[3-[[2-[4-(4-methylpiperazin-1-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide
Show/Hide
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C26H27N7O2
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1
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| 1 |
IC50 = 4 nM
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CP0240838
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N-[7-chloro-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]benzimidazol-2-yl]-2-methylpyridine-4-carboxamide
Show/Hide
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C26H31ClN6O2
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1
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| 1 |
IC50 = 4.18 nM
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CP0571686
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(3S,4R)-3-fluoro-3-methyl-1-[4-[[8-[3-(methylsulfonylmethyl)azetidin-1-yl]-5-propan-2-yl-2,7-naphthyridin-3-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
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C26H34FN7O3S
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1
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| 1 |
IC50 = 4.8 nM
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CP0210831
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N-[(3R,4R)-4-fluoro-1-[6-[(3-methoxy-1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide
Show/Hide
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C20H26FN9O2
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1
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| 1 |
IC50 = 5 nM
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CP0461892
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N-[5-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide
Show/Hide
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C27H28ClN7O2
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1
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| 1 |
IC50 = 5.6 nM
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CP0383723
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N-[(3R,4R)-1-[6-[(1-ethyl-3-methoxypyrazol-4-yl)amino]-9-methylpurin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide
Show/Hide
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C19H24FN9O2
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1
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| 1 |
IC50 = 6 nM
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CP0534799
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N-[(3R,4R)-4-fluoro-1-[6-[[3-methoxy-1-(1-methylpyrrolidin-3-yl)pyrazol-4-yl]amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide
Show/Hide
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C24H33FN10O2
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1
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| 1 |
IC50 = 6 nM
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CP0374755
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N-[3-[2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxyanilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
Show/Hide
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C29H33N7O3
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1
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| 1 |
IC50 = 6 nM
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CP0419521
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N-[5-methyl-1-(1-prop-2-enoylazepan-3-yl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Show/Hide
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C25H25F3N4O2
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1
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| 1 |
IC50 = 6.1 nM
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CP0238701
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N-[(3R,4R)-4-fluoro-1-[6-[(1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide
Show/Hide
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C19H24FN9O
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1
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| 1 |
IC50 = 7 nM
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CP0386050
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N-[4-(3-chloro-4-fluoroanilino)-7-prop-2-ynoxyquinazolin-6-yl]prop-2-enamide
Show/Hide
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C20H14ClFN4O2
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1
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| 1 |
IC50 = 7 nM
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CP0371128
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N-[(3R,4R)-1-[6-[(3-ethyl-1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide
Show/Hide
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C21H28FN9O
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1
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| 1 |
IC50 = 7 nM
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CP0393180
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N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide
Show/Hide
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C18H14ClFN4O2
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1
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| 1 |
IC50 = 7 nM
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CP0543294
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(3S,4R)-3-fluoro-1-[4-[[8-[(2R,3S)-3-hydroxy-2-methylazetidin-1-yl]-5-propan-2-yl-2,7-naphthyridin-3-yl]amino]pyrimidin-2-yl]-3-methylpiperidin-4-ol
Show/Hide
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C25H32FN7O2
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1
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| 1 |
IC50 = 7 nM
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CP0546832
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(3S,4R)-3-fluoro-3-methyl-1-[4-[[8-[(2R)-2-methylazetidin-1-yl]-5-propan-2-yl-2,7-naphthyridin-3-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
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C25H32FN7O
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1
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| 1 |
IC50 = 7 nM
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CP0401599
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1-[(3R,4R)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-(methoxymethyl)pyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
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C20H24ClN7O3
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1
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| 1 |
IC50 = 8 nM
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CP0483175
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1-[(3R,4R)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-(trifluoromethyl)pyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
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C19H19ClF3N7O2
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1
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| 1 |
IC50 = 8 nM
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CP0204238
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N-[(3R,4R)-1-[9-ethyl-6-[(3-methoxy-1-methylpyrazol-4-yl)amino]purin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide
Show/Hide
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C19H24FN9O2
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1
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| 1 |
IC50 = 8 nM
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CP0543558
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2-[4-(difluoromethyl)-6-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-7-methylindazol-2-yl]-2-spiro[6,7-dihydropyrrolo[1,2-c]imidazole-5,1'-cyclopropane]-1-yl-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C37H37F2N7O2S
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1
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| 1 |
IC50 = 8 nM
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CP0459605
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1-[(3R,4R)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-fluoropyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
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C18H19ClFN7O2
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1
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| 1 |
IC50 = 9 nM
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CP0573155
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1-[6-[[2-[(3S,4R)-3-fluoro-4-hydroxy-3-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-4-propan-2-yl-2,7-naphthyridin-1-yl]-N,N-dimethylazetidine-3-carboxamide
Show/Hide
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C27H35FN8O2
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1
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| 1 |
IC50 = 10 nM
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CP0534253
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2-(5-fluoro-2-hydroxyphenyl)-2-[3-oxo-5-(4-piperazin-1-ylphenyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)acetamide
Show/Hide
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C29H26FN5O3S
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1
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| 1 |
IC50 = 11 nM
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CP0164799
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Mavelertinib
Show/Hide
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C18H22FN9O2
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1
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| 1 |
IC50 = 12 nM
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CP0393179
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1-[(3R,4R)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-methoxypyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
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C19H22ClN7O3
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1
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| 1 |
IC50 = 13 nM
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CP0459603
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N-[3-[[2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide
Show/Hide
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C19H17N7O2
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1
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| 1 |
IC50 = 13 nM
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CP0568878
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(3S,4R)-3-fluoro-1-[4-[[8-[(2R,3S)-3-hydroxy-2-methylazetidin-1-yl]-5-propan-2-yl-2,6-naphthyridin-3-yl]amino]pyrimidin-2-yl]-3-methylpiperidin-4-ol
Show/Hide
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C25H32FN7O2
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1
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| 1 |
IC50 = 13 nM
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CP0429196
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1-[(3aS,6aR)-2-[6-[4-(4-methylpiperazin-1-yl)anilino]-9-propan-2-ylpurin-2-yl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]prop-2-en-1-one
Show/Hide
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C28H37N9O
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1
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| 1 |
IC50 = 14 nM
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CP0078880
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4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide
Show/Hide
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C30H29ClN6O3
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1
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| 1 |
IC50 < 14 nM
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CP0544970
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N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[6-(1-methylindol-3-yl)pyrazin-2-yl]amino]phenyl]prop-2-enamide
Show/Hide
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C28H33N7O2
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1
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| 1 |
IC50 = 15 nM
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CP0551865
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N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[2-(1-methylindol-3-yl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
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C28H33N7O2
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1
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| 1 |
IC50 = 15 nM
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CP0401602
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1-[(3R,4R)-3-[[2-[(1-but-3-ynylpyrazol-4-yl)amino]-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-methoxypyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
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C22H24ClN7O3
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1
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| 1 |
IC50 = 16 nM
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CP0154886
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N-[(3R,4R)-1-[9-tert-butyl-6-[(3-methoxy-1-methylpyrazol-4-yl)amino]purin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide
Show/Hide
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C21H28FN9O2
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1
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| 1 |
IC50 = 17 nM
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CP0568876
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1-[6-[[2-[(3S,4R)-3-fluoro-4-hydroxy-3-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-4-propan-2-yl-2,7-naphthyridin-1-yl]azetidine-3-carbonitrile
Show/Hide
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C25H29FN8O
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1
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| 1 |
IC50 = 17 nM
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CP0051362
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N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide
Show/Hide
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C26H27ClN8O2
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1
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| 1 |
IC50 = 19 nM
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CP0438274
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N-[(3S)-1-[6-[4-(4-methylpiperazin-1-yl)anilino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide
Show/Hide
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C26H35N9O
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1
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| 1 |
IC50 = 19 nM
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CP0568875
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(3S,4R)-3-fluoro-1-[4-[[8-[(2R,3S)-3-hydroxy-2-methylazetidin-1-yl]-5-propan-2-ylisoquinolin-3-yl]amino]pyrimidin-2-yl]-3-methylpiperidin-4-ol
Show/Hide
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C26H33FN6O2
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1
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| 1 |
IC50 = 19 nM
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CP0568872
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(3S,4R)-3-fluoro-3-methyl-1-[4-[[8-(methylamino)-5-propan-2-yl-2,7-naphthyridin-3-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
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C22H28FN7O
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1
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| 1 |
IC50 = 20 nM
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CP0568873
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(3S,4R)-1-[4-[[8-(azetidin-1-yl)-5-propan-2-yl-2,7-naphthyridin-3-yl]amino]pyrimidin-2-yl]-3-fluoro-3-methylpiperidin-4-ol
Show/Hide
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C24H30FN7O
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1
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| 1 |
IC50 = 20 nM
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CP0465796
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N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
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C22H18ClN5O2
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1
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| 1 |
IC50 = 22 nM
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CP0059062
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N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Show/Hide
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C25H27ClN6O3
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2
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| 1 |
IC50 = 23 nM
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| 2 |
IC50 = 46 nM
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CP0545095
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(3S,4R)-3-fluoro-3-methyl-1-[4-[[8-[(2R)-2-methylazetidin-1-yl]-5-propan-2-yl-2,6-naphthyridin-3-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
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C25H32FN7O
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1
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| 1 |
IC50 = 23 nM
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CP0543295
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(3S,4R)-3-fluoro-1-[4-[[8-(3-methoxyazetidin-1-yl)-5-propan-2-yl-2,7-naphthyridin-3-yl]amino]pyrimidin-2-yl]-3-methylpiperidin-4-ol
Show/Hide
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C25H32FN7O2
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1
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| 1 |
IC50 = 24 nM
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CP0442242
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N-[5-methyl-1-(1-prop-2-enoylpiperidin-3-yl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Show/Hide
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C24H23F3N4O2
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1
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| 1 |
IC50 = 24.7 nM
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CP0546823
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(3S,4R)-3-fluoro-3-methyl-1-[4-[[4-[(2R)-2-methylazetidin-1-yl]-1-propan-2-ylpyrido[3,4-d]pyridazin-7-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
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C24H31FN8O
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1
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| 1 |
IC50 = 25 nM
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CP0164797
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N-[(3R,4R)-1-[6-[(1,3-dimethylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide
Show/Hide
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C20H26FN9O
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2
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| 1 |
IC50 = 26 nM
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| 2 |
IC50 = 6138 nM
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CP0380230
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N-[3-[[2-[(1-methylpyrazol-3-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide
Show/Hide
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C19H17N7O2
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1
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| 1 |
IC50 = 27 nM
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CP0035025
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4-anilinoquinazoline deriv. 2
Show/Hide
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C17H13BrN4O
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1
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| 1 |
IC50 = 28 nM
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CP0360039
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1-[(3R)-3-[[6-[4-(4-methylpiperazin-1-yl)anilino]-9-propan-2-ylpurin-2-yl]amino]pyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
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C26H35N9O
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1
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| 1 |
IC50 = 29 nM
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CP0569543
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1-[6-[[2-[(3S,4R)-3-fluoro-4-hydroxy-3-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-4-propan-2-yl-2,7-naphthyridin-1-yl]-N-methylazetidine-3-carboxamide
Show/Hide
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C26H33FN8O2
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1
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| 1 |
IC50 = 32 nM
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CP0491725
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N-[3-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
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C21H17ClN6O2
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1
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| 1 |
IC50 = 33 nM
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CP0326484
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N-[4-(4-bromo-2-fluoroanilino)quinazolin-6-yl]prop-2-enamide
Show/Hide
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C17H12BrFN4O
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1
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| 1 |
IC50 = 36 nM
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CP0571684
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(3S,4R)-3-fluoro-1-[4-[[8-[3-(methoxymethyl)azetidin-1-yl]-5-propan-2-yl-2,7-naphthyridin-3-yl]amino]pyrimidin-2-yl]-3-methylpiperidin-4-ol
Show/Hide
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C26H34FN7O2
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1
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| 1 |
IC50 = 40 nM
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CP0204538
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N-[3-[[2-[2-methoxy-4-(4-morpholin-4-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
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C30H36N8O4
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1
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| 1 |
IC50 = 41 nM
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CP0567944
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(3S,4R)-3-fluoro-1-[4-[[8-(3-hydroxyazetidin-1-yl)-5-propan-2-yl-2,7-naphthyridin-3-yl]amino]pyrimidin-2-yl]-3-methylpiperidin-4-ol
Show/Hide
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C24H30FN7O2
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1
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| 1 |
IC50 = 41 nM
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CP0153482
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DACOMITINIB
Show/Hide
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C24H25ClFN5O2
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1
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| 1 |
IC50 = 42 nM
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CP0483173
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1-[(3R)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]pyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
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C18H20ClN7O2
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1
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| 1 |
IC50 = 45 nM
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CP0459604
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1-[(3R,4R)-3-[[2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-(trifluoromethyl)pyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
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C19H20F3N7O2
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1
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| 1 |
IC50 = 47 nM
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CP0222497
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1-[(3aS,6aR)-2-[6-[(1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]prop-2-en-1-one
Show/Hide
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C21H27N9O
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1
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| 1 |
IC50 = 49 nM
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CP0164796
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N-[(3S)-1-[6-[(1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide
Show/Hide
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C19H25N9O
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1
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| 1 |
IC50 = 52 nM
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CP0575807
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(3S,4R)-3-fluoro-3-methyl-1-[4-[(5-propan-2-yl-8-pyrrolidin-1-yl-2,7-naphthyridin-3-yl)amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
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C25H32FN7O
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1
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| 1 |
IC50 = 52 nM
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CP0391959
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(E)-N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]-4-(dimethylamino)but-2-enamide
Show/Hide
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C25H25ClN6O2
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1
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| 1 |
IC50 = 53 nM
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CP0520799
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N-[3-[[2-[4-[4-(diethylamino)piperidin-1-yl]-2-methoxyanilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
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C30H38N8O3
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1
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| 1 |
IC50 = 55 nM
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CP0124322
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N-[5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide
Show/Hide
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C27H29N7O2
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2
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| 1 |
IC50 = 63 nM
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| 2 |
IC50 = 68 nM
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CP0546834
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(3S,4R)-3-fluoro-1-[4-[[8-(methylamino)-5-propan-2-yl-2,7-naphthyridin-3-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
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C21H26FN7O
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1
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| 1 |
IC50 = 67 nM
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CP0389113
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N-[4-methoxy-2-(4-methylpiperazin-1-yl)-5-[(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]phenyl]prop-2-enamide
Show/Hide
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C26H28N8O2
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1
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| 1 |
IC50 = 71 nM
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CP0438275
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3-methyl-2-[[6-(4-piperazin-1-ylanilino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
Show/Hide
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C23H34N8O
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1
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| 1 |
IC50 = 78 nM
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CP0404048
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N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
Show/Hide
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C21H16ClN5O
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1
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| 1 |
IC50 = 81 nM
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CP0561775
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N-[3-[[2-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyanilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
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C28H34N8O3
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1
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| 1 |
IC50 = 82 nM
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CP0072400
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(E)-N-[3-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxyphenyl]-4-(dimethylamino)but-2-enamide
Show/Hide
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C24H24ClN7O2
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2
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| 1 |
IC50 = 91 nM
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| 2 |
IC50 = 96 nM
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CP0526436
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N-[3-[[2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
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C31H39N9O3
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1
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| 1 |
IC50 = 105 nM
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CP0412396
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N-[3-[[2-[4-(diethylamino)-2-methoxyanilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
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C25H29N7O3
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1
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| 1 |
IC50 = 112 nM
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CP0401601
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1-[(3S,4S)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-methoxypyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
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C19H22ClN7O3
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1
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| 1 |
IC50 = 120 nM
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CP0663369
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1-(4-((4-ethylphenyl)amino)-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-7(8H)-yl)prop-2-en-1-one
Show/Hide
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C20H20N4OS
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1
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| 1 |
IC50 = 130 nM
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CP0411319
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N-[3-[[2-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
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C27H31N7O3
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1
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| 1 |
IC50 = 130 nM
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CP0521635
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N-[3-[[5-chloro-2-[2-methoxy-4-(4-morpholin-4-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
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C30H35ClN8O4
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1
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| 1 |
IC50 = 131 nM
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CP0204540
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US10434101, Compound I-10
Show/Hide
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C27H27F3N6O4
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1
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| 1 |
IC50 = 132 nM
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CP0396216
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N-[5-methyl-1-[3-(prop-2-enoylamino)phenyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Show/Hide
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C25H19F3N4O2
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1
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| 1 |
IC50 = 134.8 nM
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CP0385108
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N-[5-methyl-1-[3-[methyl(prop-2-enoyl)amino]phenyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Show/Hide
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C26H21F3N4O2
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1
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| 1 |
IC50 = 181 nM
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CP0258411
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N-[5-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
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C27H30ClN7O2
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1
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| 1 |
IC50 = 200 nM
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CP0380235
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1-[(3R,4R)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-hydroxypyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
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C18H20ClN7O3
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1
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| 1 |
IC50 = 210 nM
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CP0545096
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(3S,4R)-3-fluoro-3-methyl-1-[4-[[8-[(2S)-2-methylazetidin-1-yl]-5-propan-2-yl-2,7-naphthyridin-3-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
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C25H32FN7O
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1
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| 1 |
IC50 = 210 nM
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CP0459276
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N-[3-[[2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
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C25H27N7O4
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1
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| 1 |
IC50 = 218 nM
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CP0432326
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(E)-4-(dimethylamino)-N-[3-[(5-fluoro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxyphenyl]but-2-enamide
Show/Hide
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C24H24FN7O2
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1
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| 1 |
IC50 = 220 nM
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CP0426650
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(E)-4-(dimethylamino)-N-[4-methoxy-3-[(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]phenyl]but-2-enamide
Show/Hide
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C24H25N7O2
|
1
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| 1 |
IC50 = 250 nM
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CP0201625
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N-[2-[(3R,4S)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl]-2-methyl-1-propan-2-ylimidazo[4,5-c]pyridin-6-amine
Show/Hide
|
C20H26FN7O
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1
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| 1 |
IC50 = 250 nM
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CP0839405
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N-(4-(3-ethylphenylamino)quinazolin-6-yl)acrylamide
Show/Hide
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C19H18N4O
|
1
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| 1 |
IC50 = 275 nM
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CP0834116
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1-(4-((2-fluoro-3-methylphenyl)amino)-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-7(8H)-yl)prop-2-en-1-one
Show/Hide
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C19H17FN4OS
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1
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| 1 |
IC50 = 280 nM
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CP0551864
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1-[(3S)-3-[[6-[4-(4-methylpiperazin-1-yl)anilino]-9-propan-2-ylpurin-2-yl]amino]pyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
|
C26H35N9O
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1
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| 1 |
IC50 = 280 nM
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CP0456898
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(E)-4-(dimethylamino)-N-[4-methoxy-3-[(5-methyl-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]phenyl]but-2-enamide
Show/Hide
|
C25H27N7O2
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1
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| 1 |
IC50 = 290 nM
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CP0127236
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[6-[[2-[(3R,4S)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl]amino]-1-propan-2-ylimidazo[4,5-c]pyridin-2-yl]methanol
Show/Hide
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C20H26FN7O2
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1
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| 1 |
IC50 = 290 nM
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CP0383724
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N-[(3S)-1-[9-(2-hydroxyethyl)-6-[4-(4-methylpiperazin-1-yl)anilino]purin-2-yl]pyrrolidin-3-yl]prop-2-enamide
Show/Hide
|
C25H33N9O2
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1
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| 1 |
IC50 = 387 nM
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CP0412397
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N-[3-[[2-(2,4-dimethoxyanilino)pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
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C22H22N6O4
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1
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| 1 |
IC50 = 391 nM
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CP0568870
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6-[[2-[(3S,4R)-3-fluoro-4-hydroxypiperidin-1-yl]pyrimidin-4-yl]amino]-N-methyl-4-(propan-2-ylamino)pyridine-3-carboxamide
Show/Hide
|
C19H26FN7O2
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1
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| 1 |
IC50 = 420 nM
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CP0478429
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N-[3-[[2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxyanilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
|
C26H32N8O3
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1
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| 1 |
IC50 = 430 nM
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CP0081362
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4-fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol
Show/Hide
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C27H23FN4O2
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1
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| 1 |
IC50 = 447.6 nM
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CP0459275
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N-[3-[[2-[4-[4-(2-fluoroethyl)piperazin-1-yl]-2-methoxyanilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
|
C27H31FN8O3
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1
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| 1 |
IC50 = 511 nM
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CP0428083
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N-[5-methyl-1-[3-(prop-2-enoylamino)propyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C22H21F3N4O2
|
1
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| 1 |
IC50 = 525 nM
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CP0144128
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N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
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C26H29ClN8O2
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1
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| 1 |
IC50 = 600 nM
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CP0154887
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N-[(3R,4R)-4-fluoro-1-[6-[(3-methoxy-1-methylpyrazol-4-yl)amino]-7H-purin-2-yl]pyrrolidin-3-yl]prop-2-enamide
Show/Hide
|
C17H20FN9O2
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1
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| 1 |
IC50 = 675 nM
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CP0380237
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1-[(3R,4R)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-(hydroxymethyl)pyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
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C19H22ClN7O3
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1
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| 1 |
IC50 = 710 nM
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CP0361447
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N-[(3S,4S)-4-fluoro-1-[6-[(1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide
Show/Hide
|
C19H24FN9O
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1
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| 1 |
IC50 = 713 nM
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CP0491530
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N-[3-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]prop-2-enamide
Show/Hide
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C27H21ClN6O2
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1
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| 1 |
IC50 = 739 nM
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CP0295744
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1-[4-[4-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone
Show/Hide
|
C25H25ClN6O2
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1
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| 1 |
IC50 = 770 nM
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CP0486641
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N-[5-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-[2-(dimethylamino)ethoxy]phenyl]prop-2-enamide
Show/Hide
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C31H30ClN7O3
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1
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| 1 |
IC50 = 807 nM
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CP0201623
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N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-3H-imidazo[4,5-c]pyridin-6-amine
Show/Hide
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C16H19N7O
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1
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| 1 |
IC50 = 880 nM
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CP0256596
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N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-methyl-1-propan-2-ylimidazo[4,5-c]pyridin-6-amine
Show/Hide
|
C20H27N7O
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1
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| 1 |
IC50 = 882 nM
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CP0091599
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N-[5-[[5-cyano-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C29H32N8O2
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1
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| 1 |
IC50 = 900 nM
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CP0520800
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N-[3-[[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Show/Hide
|
C26H30N8O3
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1
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| 1 |
IC50 = 906 nM
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CP0545097
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6-[[2-(4-hydroxypiperidin-1-yl)pyrimidin-4-yl]amino]-N-methyl-4-(propan-2-ylamino)pyridine-3-carboxamide
Show/Hide
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C19H27N7O2
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1
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| 1 |
IC50 = 914 nM
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CP0664238
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N-(4-(2,4-dimethoxyphenylamino)quinazolin-6-yl)acrylamide
Show/Hide
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C19H18N4O3
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1
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| 1 |
IC50 = 931 nM
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CP0362792
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N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[5-methyl-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C29H35N7O2
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1
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| 1 |
IC50 = 1000 nM
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CP0134015
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(3R,4S)-3-fluoro-1-[4-[(2-methyl-1-propan-2-ylimidazo[4,5-c]pyridin-6-yl)amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
|
C19H24FN7O
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1
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| 1 |
IC50 = 1000 nM
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CP0374777
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[6-[[2-[(4S)-3,3-difluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl]amino]-1-propan-2-ylimidazo[4,5-c]pyridin-2-yl]methanol
Show/Hide
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C20H25F2N7O2
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1
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| 1 |
IC50 = 1000 nM
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CP0486584
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(4S)-3,3-difluoro-1-[4-[(2-methyl-1-propan-2-ylimidazo[4,5-c]pyridin-6-yl)amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
|
C19H23F2N7O
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1
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| 1 |
IC50 = 1040 nM
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CP0860175
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N-(4-(2-ethylphenylamino)quinazolin-6-yl)acrylamide
Show/Hide
|
C19H18N4O
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1
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| 1 |
IC50 = 2000 nM
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CP0213589
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N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C27H29ClN8O2
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1
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| 1 |
IC50 = 2000 nM
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CP0237594
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N-[5-[[5-chloro-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
Show/Hide
|
C28H32ClN7O2
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1
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| 1 |
IC50 = 2000 nM
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CP0391960
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1-[6-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-5-methoxy-2,3-dihydroindol-1-yl]prop-2-en-1-one
Show/Hide
|
C24H20ClN5O2
|
1
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| 1 |
IC50 = 2100 nM
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CP0403778
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N-[3-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxyphenyl]-4-(dimethylamino)butanamide
Show/Hide
|
C24H26ClN7O2
|
1
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| 1 |
IC50 = 2300 nM
|
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CP0134014
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[6-[[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amino]-1-propan-2-ylimidazo[4,5-c]pyridin-2-yl]methanol
Show/Hide
|
C20H27N7O2
|
1
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| 1 |
IC50 = 2360 nM
|
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CP0234873
|
(3R,4S)-3-fluoro-1-[4-[[2-(hydroxymethyl)-1-propan-2-ylimidazo[4,5-c]pyridin-6-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
|
C19H24FN7O2
|
1
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| 1 |
IC50 = 2530 nM
|
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CP0513510
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N-[3-[4-[4-[(1,3-dioxoisoindol-2-yl)methyl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]prop-2-enamide
Show/Hide
|
C30H22N6O3
|
1
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| 1 |
IC50 = 2664 nM
|
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CP0408469
|
N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]-2-cyanoacetamide
Show/Hide
|
C22H17ClN6O2
|
1
|
| 1 |
IC50 = 2800 nM
|
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CP0755044
|
N-(4-(cyclohexylamino)quinazolin-6-yl)acrylamide
Show/Hide
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C17H20N4O
|
1
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| 1 |
IC50 = 2800 nM
|
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CP0412395
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N-[3-[[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
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C25H28N8O2
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1
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| 1 |
IC50 = 3146 nM
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CP0124287
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N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-2-[3-(dimethylamino)azetidin-1-yl]-4-methoxyphenyl]prop-2-enamide
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C26H27ClN8O2
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1
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| 1 |
IC50 = 4000 nM
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CP0834117
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N-(4-(4-(N-pyridin-2-ylsulfamoyl)phenylamino)quinazolin-6-yl)acrylamide
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C22H18N6O3S
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1
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| 1 |
IC50 = 4390 nM
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CP0037987
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N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
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C22H23N3O4
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4
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| 1 |
IC50 = 7600 nM
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| 2 |
IC50 = 9000 nM
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| 3 |
IC50 = 9003 nM
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| 4 |
IC50 > 5000 nM
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CP0486082
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N-[3-[[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
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C24H25N7O3
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1
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| 1 |
IC50 > 10000 nM
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CP0391961
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N-[4-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
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C21H16ClN5O
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1
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| 1 |
IC50 = 12900 nM
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CP0007142
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N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
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C29H26ClFN4O4S
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1
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| 1 |
IC50 = 14781 nM
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CP0389114
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(E)-4-(dimethylamino)-N-[4-methoxy-3-[(5-methylsulfinyl-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]phenyl]but-2-enamide
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C25H27N7O3S
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1
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| 1 |
IC50 = 15200 nM
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CP0508680
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N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-2-[4-[2-(dimethylamino)acetyl]piperazin-1-yl]-4-methoxyphenyl]prop-2-enamide
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C29H32ClN9O3
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1
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| 1 |
IC50 = 16000 nM
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CP0488276
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N-[2-[4-[(2S)-2-aminopropanoyl]piperazin-1-yl]-5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxyphenyl]prop-2-enamide
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C28H30ClN9O3
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1
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| 1 |
IC50 = 19000 nM
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CP0134016
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(1R)-1-[6-[[2-[(3R,4S)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl]amino]-1-[(2R)-1,1,1-trifluoropropan-2-yl]imidazo[4,5-c]pyridin-2-yl]ethanol
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C21H25F4N7O2
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1
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| 1 |
IC50 = 21000 nM
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CP0415837
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N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxy-2-[4-[(2S)-piperidine-2-carbonyl]piperazin-1-yl]phenyl]prop-2-enamide
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C31H34ClN9O3
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1
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| 1 |
IC50 = 31000 nM
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CP0415838
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N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxy-2-[4-[(2R)-piperidine-2-carbonyl]piperazin-1-yl]phenyl]prop-2-enamide
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C31H34ClN9O3
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1
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| 1 |
IC50 = 57000 nM
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CP0488277
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N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxy-2-[4-[2-(methylamino)acetyl]piperazin-1-yl]phenyl]prop-2-enamide
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C28H30ClN9O3
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1
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| 1 |
IC50 = 66000 nM
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CP0463430
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N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-2-[4-[(2S)-2-hydroxypropanoyl]piperazin-1-yl]-4-methoxyphenyl]prop-2-enamide
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C28H29ClN8O4
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1
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| 1 |
IC50 = 75000 nM
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CP0669629
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1-(4-Cyclohexylamino)-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-7(8H)-yl)prop-2-en-1-one
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C18H22N4OS
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1
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| 1 |
IC50 > 5000 nM
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