Brief Information of the Compound and Protein
Compound Name
N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[6-(3-fluorophenyl)-1H-indazol-3-yl]amino]-4-methoxyphenyl]prop-2-enamide
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PubChem ID
CID: 137639100
Canonical SMILES
COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1n[nH]c2cc(ccc12)-c1cccc(F)c1
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Compound Formula C28H31FN6O2
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431 Homo sapiens (Human)  1
1
EC50 = 2277 nM
   TI
   LI
   LO
   TS
CL000157 NCI-H1975 Homo sapiens (Human)  1
1
EC50 = 608 nM
   TI
   LI
   LO
   TS