General Information of the Compound
Compound ID
CP0033949
Compound Name
2-[2-(2-methoxyanilino)pyrimidin-4-yl]-1'-prop-2-enoylspiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one
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Structure
Formula
C25H26N6O3
Molecular Weight
458.522
Canonical SMILES
COc1ccccc1Nc1nccc(n1)-c1cc2c([nH]1)C1(CCN(CC1)C(=O)C=C)CNC2=O
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InChI
InChI=1S/C25H26N6O3/c1-3-21(32)31-12-9-25(10-13-31)15-27-23(33)16-14-19(28-22(16)25)17-8-11-26-24(29-17)30-18-6-4-5-7-20(18)34-2/h3-8,11,14,28H,1,9-10,12-13,15H2,2H3,(H,27,33)(H,26,29,30)
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InChIKey
RCLLYPKRFIZQIZ-UHFFFAOYSA-N
Physicochemical Property
logP
3.0135
Rotatable Bonds
5
Heavy Atom Count
34
Polar Areas
112.24
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166626802
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000157 NCI-H1975 Homo sapiens (Human)  2
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
2
EC50 = 308 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.4 nM
2 IC50 = 0.9 nM