General Information of the Compound
Compound ID
CP0521635
Compound Name
N-[3-[[5-chloro-2-[2-methoxy-4-(4-morpholin-4-ylpiperidin-1-yl)anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
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Structure
Formula
C30H35ClN8O4
Molecular Weight
607.115
Canonical SMILES
COc1cc(ccc1Nc1ncc(Cl)c(NC(=O)Nc2cccc(NC(=O)C=C)c2)n1)N1CCC(CC1)N1CCOCC1
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InChI
InChI=1S/C30H35ClN8O4/c1-3-27(40)33-20-5-4-6-21(17-20)34-30(41)37-28-24(31)19-32-29(36-28)35-25-8-7-23(18-26(25)42-2)38-11-9-22(10-12-38)39-13-15-43-16-14-39/h3-8,17-19,22H,1,9-16H2,2H3,(H,33,40)(H3,32,34,35,36,37,41)
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InChIKey
GOKFAZOSPCHSOH-UHFFFAOYSA-N
Physicochemical Property
logP
4.9517
Rotatable Bonds
9
Heavy Atom Count
43
Polar Areas
132.98
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118352116
ChEMBL ID
CHEMBL4226562
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000157 NCI-H1975 Homo sapiens (Human)  1
1
IC50 = 131 nM
   TI
   LI
   LO
   TS
CL000052 A-431 Homo sapiens (Human)  1
1
IC50 = 2210 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431 Homo sapiens (Human)  1
1
IC50 = 2592 nM
   TI
   LI
   LO
   TS