Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[5-chloro-2-(2-methoxyanilino)pyrimidin-4-yl]-1'-prop-2-enoylspiro[5,6-dihydro-1H-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one
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 PubChem ID
CID: 166626903
Canonical SMILES
COc1ccccc1Nc1ncc(Cl)c(n1)-c1cc2c([nH]1)C1(CCN(CC1)C(=O)C=C)CNC2=O
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Compound Formula C25H25ClN6O3
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000157 NCI-H1975
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 3.1 nM
   TI
   LI
   LO
   TS
2
EC50 = 277 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.8 nM
2 IC50 = 0.9 nM