General Information of the Compound
Compound ID
CP0134014
Compound Name
[6-[[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amino]-1-propan-2-ylimidazo[4,5-c]pyridin-2-yl]methanol
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Structure
Formula
C20H27N7O2
Molecular Weight
397.483
Canonical SMILES
COC1CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(CO)nc3cn2)n1
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InChI
InChI=1S/C20H27N7O2/c1-13(2)27-16-10-18(22-11-15(16)23-19(27)12-28)24-17-4-7-21-20(25-17)26-8-5-14(29-3)6-9-26/h4,7,10-11,13-14,28H,5-6,8-9,12H2,1-3H3,(H,21,22,24,25)
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InChIKey
BROYMMFRLLTITA-UHFFFAOYSA-N
Physicochemical Property
logP
2.6533
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
101.22
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90183305
ChEMBL ID
CHEMBL3734877
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000157 NCI-H1975 Homo sapiens (Human)  1
1
IC50 = 2360 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 400 nM