Brief Information of the Compound and Protein
| Compound Name |
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
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PubChem ID | |||||
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Compound Structure |
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| Protein Name |
Epidermal growth factor receptor
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Protein Classification |
Enzyme
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Kinase
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Protein Kinase
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TK protein kinase group
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Tyrosine protein kinase EGFR family
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| Uniprot ID | Gene Name | EGFR |
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Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Biochemical Assays
| 1 | IC50 = 1.4 nM | ||
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| 2 | IC50 = 1.7 nM | ||
| 3 | IC50 = 2.16 nM | ||
| 4 | IC50 = 3.2 nM | ||
| 5 | IC50 = 4.4 nM | ||
| 6 | IC50 = 6.18 nM | ||
| 7 | IC50 = 6.47 nM | ||
| 8 | IC50 = 35 nM | ||
| 9 | IC50 = 79 nM | ||
| 10 | Kd = 46 nM | ||