| Compound ID |
Compound Name |
Compound Formula |
|
CP0852604
|
(R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C25H24ClN7O2
|
2
|
| 1 |
EC50 < 10 nM
|
|
|
| 2 |
GI50 = 4 nM
|
|
|
|
CP0033646
|
AZD-9291
Show/Hide
|
C28H33N7O2
|
1
|
| 1 |
GI50 = 2 nM
|
|
|
|
CP0007430
|
IBRUTINIB
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|
C25H24N6O2
|
1
|
| 1 |
GI50 = 50 nM
|
|
|
|
CP0857303
|
(R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Show/Hide
|
C25H26ClN7O2
|
1
|
| 1 |
GI50 = 4400 nM
|
|
|
|
CP0393180
|
N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide
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|
C18H14ClFN4O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0210831
|
N-[(3R,4R)-4-fluoro-1-[6-[(3-methoxy-1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide
Show/Hide
|
C20H26FN9O2
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0164799
|
Mavelertinib
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|
C18H22FN9O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0081362
|
4-fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol
Show/Hide
|
C27H23FN4O2
|
1
|
| 1 |
IC50 = 5.3 nM
|
|
|
|
CP0238701
|
N-[(3R,4R)-4-fluoro-1-[6-[(1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide
Show/Hide
|
C19H24FN9O
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0037987
|
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
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|
C22H23N3O4
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0036082
|
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Show/Hide
|
C22H24ClFN4O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0164797
|
N-[(3R,4R)-1-[6-[(1,3-dimethylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide
Show/Hide
|
C20H26FN9O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0134016
|
(1R)-1-[6-[[2-[(3R,4S)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl]amino]-1-[(2R)-1,1,1-trifluoropropan-2-yl]imidazo[4,5-c]pyridin-2-yl]ethanol
Show/Hide
|
C21H25F4N7O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0551865
|
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[2-(1-methylindol-3-yl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C28H33N7O2
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0065286
|
AVL-301
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|
C27H28F3N7O3
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0201626
|
(3R,4S)-3-fluoro-1-[4-[[2-[(1R)-1-hydroxyethyl]-1-[(2R)-1,1,1-trifluoropropan-2-yl]imidazo[4,5-c]pyridin-6-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Show/Hide
|
C20H23F4N7O2
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0059062
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Show/Hide
|
C25H27ClN6O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0564476
|
BLU-945
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|
C28H37FN6O3S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0393179
|
1-[(3R,4R)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-methoxypyrrolidin-1-yl]prop-2-en-1-one
Show/Hide
|
C19H22ClN7O3
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0408607
|
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-hydroxyacetamide
Show/Hide
|
C24H27ClN6O4
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0478346
|
4-(2-azidophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C22H23ClN8O2
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0905680
|
N-(2-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)-2-benzyloxyacetamide
Show/Hide
|
C31H33ClN6O4
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0408596
|
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-hydroxypropanamide
Show/Hide
|
C25H29ClN6O4
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
|
CP0471792
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-hydroxyacetamide
Show/Hide
|
C24H27ClN6O4
|
1
|
| 1 |
IC50 = 1060 nM
|
|
|
|
CP0429397
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-phenylmethoxypropanamide
Show/Hide
|
C32H35ClN6O4
|
1
|
| 1 |
IC50 = 1090 nM
|
|
|
|
CP0472903
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-phenylmethoxypropanamide
Show/Hide
|
C32H35ClN6O4
|
1
|
| 1 |
IC50 = 1410 nM
|
|
|
|
CP0408606
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-hydroxyacetamide
Show/Hide
|
C24H27ClN6O4
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0472904
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-hydroxypropanamide
Show/Hide
|
C25H29ClN6O4
|
1
|
| 1 |
IC50 = 1590 nM
|
|
|
|
CP0429398
|
4-(2-aminophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C22H25ClN6O2
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0482004
|
5-chloro-4-(2-isothiocyanatophenoxy)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C23H23ClN6O2S
|
1
|
| 1 |
IC50 = 1820 nM
|
|
|
|
CP0905681
|
N-(2-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)-3-benzyloxypropanamide
Show/Hide
|
C32H35ClN6O4
|
1
|
| 1 |
IC50 = 1980 nM
|
|
|
|
CP0408609
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-phenylmethoxyacetamide
Show/Hide
|
C31H33ClN6O4
|
1
|
| 1 |
IC50 = 2550 nM
|
|
|
|
CP0408613
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-phenylmethoxyacetamide
Show/Hide
|
C31H33ClN6O4
|
1
|
| 1 |
IC50 = 2700 nM
|
|
|
|
CP0482007
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Show/Hide
|
C25H27ClN6O3
|
1
|
| 1 |
IC50 = 2820 nM
|
|
|
|
CP0534556
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]acetamide
Show/Hide
|
C24H27ClN6O3
|
1
|
| 1 |
IC50 = 3080 nM
|
|
|
|
CP0408612
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]acetamide
Show/Hide
|
C24H27ClN6O3
|
1
|
| 1 |
IC50 = 3270 nM
|
|
|
|
CP0408611
|
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]acetamide
Show/Hide
|
C24H27ClN6O3
|
1
|
| 1 |
IC50 = 4210 nM
|
|
|
|
CP0511869
|
(E)-N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-4-(dimethylamino)but-2-enamide
Show/Hide
|
C28H34ClN7O3
|
1
|
| 1 |
IC50 = 5010 nM
|
|
|
|
CP0408650
|
5-chloro-4-(3-isothiocyanatophenoxy)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C23H23ClN6O2S
|
1
|
| 1 |
IC50 = 5610 nM
|
|
|
|
CP0432728
|
(E)-N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-4-(dimethylamino)but-2-enamide
Show/Hide
|
C28H34ClN7O3
|
1
|
| 1 |
IC50 = 6070 nM
|
|
|
|
CP0408610
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-hydroxypropanamide
Show/Hide
|
C25H29ClN6O4
|
1
|
| 1 |
IC50 = 6120 nM
|
|
|
|
CP0518127
|
4-(3-aminophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C22H25ClN6O2
|
1
|
| 1 |
IC50 = 6490 nM
|
|
|
|
CP0482008
|
4-(4-aminophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C22H25ClN6O2
|
1
|
| 1 |
IC50 = 7370 nM
|
|
|
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CP0408652
|
4-(3-azidophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C22H23ClN8O2
|
1
|
| 1 |
IC50 = 7430 nM
|
|
|
|
CP0478344
|
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(2-nitrophenoxy)pyrimidin-2-amine
Show/Hide
|
C22H23ClN6O4
|
1
|
| 1 |
IC50 = 7590 nM
|
|
|
|
CP0472905
|
(E)-N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-4-(dimethylamino)but-2-enamide
Show/Hide
|
C28H34ClN7O3
|
1
|
| 1 |
IC50 = 8070 nM
|
|
|
|
CP0408595
|
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Show/Hide
|
C25H27ClN6O3
|
1
|
| 1 |
IC50 = 8420 nM
|
|
|
|
CP0432729
|
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(3-nitrophenoxy)pyrimidin-2-amine
Show/Hide
|
C22H23ClN6O4
|
1
|
| 1 |
IC50 = 8870 nM
|
|
|
|
CP0494495
|
5-chloro-4-(4-isothiocyanatophenoxy)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C23H23ClN6O2S
|
1
|
| 1 |
IC50 = 9040 nM
|
|
|
|
CP0432757
|
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(4-nitrophenoxy)pyrimidin-2-amine
Show/Hide
|
C22H23ClN6O4
|
1
|
| 1 |
IC50 = 9360 nM
|
|
|
|
CP0482006
|
4-(4-azidophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C22H23ClN8O2
|
1
|
| 1 |
IC50 = 9760 nM
|
|
|
