Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

AVL-301

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PubChem ID

CID: 57335384

SID: 136337802

Canonical SMILES	COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O Show/Hide
Compound Formula	C27H28F3N7O3

Compound Structure

Protein Name

Protein Info

Epidermal growth factor receptor

Protein Classification

Enzyme

Kinase

Protein Kinase

TK protein kinase group

Tyrosine protein kinase EGFR family

Uniprot ID

P00533

Gene Name

EGFR

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000052	A-431 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 1655 nM	TI LI LO TS
CL000068	A-549 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 1598 nM	TI LI LO TS
CL000150	HaCaT Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 262.3 nM	TI LI LO TS
CL000157	NCI-H1975 Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 118 nM	TI LI LO TS
2	IC50 = 4.1 nM	TI LI LO TS
3	IC50 = 16 nM	TI LI LO TS
CL000324	NCI-H3255 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 13.8 nM	TI LI LO TS
CL000379	PC-9 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 79 nM	TI LI LO TS
CL000923	PC9-DRH Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 9 nM	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	8
1	IC50 = 2 nM	TI LI LO TS
2	IC50 = 3 nM	TI LI LO TS
3	IC50 = 20 nM	TI LI LO TS
4	IC50 = 21.5 nM	TI LI LO TS
5	IC50 = 460 nM	TI LI LO TS
6	IC50 = 500 nM	TI LI LO TS
7	Ki = 1.65 nM	TI LI LO TS
8	Ki = 1.75 nM	TI LI LO TS

Biochemical Assays