General Information of the Compound
| Compound ID |
CP0408652
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| Compound Name |
4-(3-azidophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
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| Structure |
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| Formula |
C22H23ClN8O2
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| Molecular Weight |
466.933
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| Canonical SMILES |
COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(c2)N=[N+]=[N-])n1)N1CCN(C)CC1
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| InChI |
InChI=1S/C22H23ClN8O2/c1-30-8-10-31(11-9-30)16-6-7-19(20(13-16)32-2)26-22-25-14-18(23)21(27-22)33-17-5-3-4-15(12-17)28-29-24/h3-7,12-14H,8-11H2,1-2H3,(H,25,26,27)
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| InChIKey |
GHORRHODUODRLJ-UHFFFAOYSA-N
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Protein ID: PT03338, Tyrosine-protein kinase ABL1