General Information of the Cell Line
Cell Line ID
CL000561
Cell Line Name
LOX-IMVI
Synonyms
LOX/IMVI
LOX IMVI
LOXIM-VI
LOXIMVI
LOX
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1381
Tissue Information
Lymph node
Disease
Amelanotic melanoma (NCIt: C3802)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT05526, Glutathione peroxidase 4
 Protein Info 
Compound ID Compound Name Compound Formula
CP0917680
 Compound Info 
(1S,3R)-methyl 2-(2-chloroacetyl)-1-(4-(methoxycarbonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
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C23H21ClN2O5
  2
1
EC50 = 12 nM
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2
EC50 = 3800 nM
 Bioactivity Info 
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CP0133489
 Compound Info 
2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide
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C23H22Cl2N2O3S
  2
1
EC50 = 28 nM
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2
EC50 = 2200 nM
 Bioactivity Info 
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CP0479526
 Compound Info 
[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
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C22H20Cl2N4O4
  2
1
EC50 = 44 nM
 Bioactivity Info 
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2
EC50 > 33000 nM
 Bioactivity Info 
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CP0479507
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]prop-2-ynamide
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C24H21ClN2O3S
  2
1
EC50 = 150 nM
 Bioactivity Info 
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2
EC50 = 19800 nM
 Bioactivity Info 
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CP0491514
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]-3-trimethylsilylprop-2-ynamide
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C27H29ClN2O3SSi
  2
1
EC50 = 210 nM
 Bioactivity Info 
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2
EC50 > 33000 nM
 Bioactivity Info 
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CP0468757
 Compound Info 
2-chloro-N-heptyl-N-(3-methylphenyl)acetamide
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C16H24ClNO
  2
1
EC50 = 340 nM
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2
EC50 = 30000 nM
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CP0479522
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]-3-triethylsilylprop-2-ynamide
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C30H35ClN2O3SSi
  2
1
EC50 = 370 nM
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2
EC50 > 33000 nM
 Bioactivity Info 
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CP0479509
 Compound Info 
1-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-2-chloroethanone
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C19H19Cl3N2O
  2
1
EC50 = 420 nM
 Bioactivity Info 
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2
EC50 = 4200 nM
 Bioactivity Info 
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CP0500339
 Compound Info 
2-(N-(2-bromoacetyl)-3-chloro-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide
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C23H22BrClN2O3S
  2
1
EC50 = 600 nM
 Bioactivity Info 
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2
EC50 = 5200 nM
 Bioactivity Info 
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CP0500348
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-3-[dimethyl(phenyl)silyl]-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]prop-2-ynamide
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C32H31ClN2O3SSi
  2
1
EC50 = 1000 nM
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2
EC50 > 33000 nM
 Bioactivity Info 
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CP0479523
 Compound Info 
2-chloro-1-(1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)ethanone
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C13H13ClN2O
  2
1
EC50 = 1200 nM
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2
EC50 = 1400 nM
 Bioactivity Info 
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CP0515096
 Compound Info 
1-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]prop-2-yn-1-one
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C20H18Cl2N2O
  2
1
EC50 = 1200 nM
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2
EC50 = 3600 nM
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CP0439662
 Compound Info 
MLS001172197
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C19H18ClNO4
  2
1
EC50 = 1600 nM
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2
EC50 > 33000 nM
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CP0500342
 Compound Info 
1-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-3-trimethylsilylprop-2-yn-1-one
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C23H26Cl2N2OSi
  2
1
EC50 = 1800 nM
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2
EC50 = 4800 nM
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CP0513512
 Compound Info 
N-heptyl-5-methyl-N-(3-methylphenyl)-4-nitro-1,2-oxazole-3-carboxamide
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C19H25N3O4
  2
1
EC50 = 5800 nM
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2
EC50 > 33000 nM
 Bioactivity Info 
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CP0571774
 Compound Info 
(3Z)-N-(3-chloro-4-methoxyphenyl)-3-hydroxyimino-3-nitro-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]propanamide
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C24H23ClN4O6S
  2
1
EC50 = 10100 nM
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2
EC50 > 33000 nM
 Bioactivity Info 
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CP0479510
 Compound Info 
methyl (E)-4-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-4-oxobut-2-enoate
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C22H22Cl2N2O3
  2
1
EC50 = 18000 nM
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2
EC50 = 19000 nM
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CP0548279
 Compound Info 
(E)-2-[4-[bis(4-chlorophenyl)methyl]piperazine-1-carbonyl]but-2-enenitrile
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C22H21Cl2N3O
  2
1
EC50 = 22000 nM
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2
EC50 = 24000 nM
 Bioactivity Info 
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CP0565180
 Compound Info 
1-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]but-2-yn-1-one
   Show/Hide
C21H20Cl2N2O
  2
1
EC50 = 24000 nM
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2
EC50 = 26000 nM
 Bioactivity Info 
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CP0500347
 Compound Info 
(E)-1-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-3-nitroprop-2-en-1-one
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C20H19Cl2N3O3
  2
1
EC50 = 30000 nM
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2
EC50 = 31000 nM
 Bioactivity Info 
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CP0515093
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-4-hydroxy-4-methyl-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]pent-2-ynamide
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C27H27ClN2O4S
  2
1
EC50 = 32000 nM
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2
EC50 = 33000 nM
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CP0479524
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-5-methyl-4-nitro-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]-1,2-oxazole-3-carboxamide
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C26H23ClN4O6S
  1
1
EC50 > 33000 nM
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CP0479525
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-3-nitro-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]propanamide
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C24H24ClN3O5S
  1
1
EC50 > 33000 nM
 Bioactivity Info 
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CP0500344
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]prop-2-enamide
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C24H23ClN2O3S
  1
1
EC50 > 33000 nM
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CP0500345
 Compound Info 
1-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]prop-2-en-1-one
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C20H20Cl2N2O
  1
1
EC50 > 33000 nM
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CP0500346
 Compound Info 
(E)-1-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]but-2-en-1-one
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C21H22Cl2N2O
  1
1
EC50 > 33000 nM
 Bioactivity Info 
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CP0512775
 Compound Info 
2-bromo-N-(3-chloro-4-methoxyphenyl)-2,2-difluoro-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]acetamide
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C23H20BrClF2N2O3S
  1
1
EC50 > 33000 nM
 Bioactivity Info 
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CP0512776
 Compound Info 
[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-(2-chloropyridin-4-yl)methanone
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C23H20Cl3N3O
  1
1
EC50 > 33000 nM
 Bioactivity Info 
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CP0513513
 Compound Info 
1-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]propane-1,2-dione
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C20H20Cl2N2O2
  1
1
EC50 > 33000 nM
 Bioactivity Info 
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CP0545888
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]but-2-ynamide
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C25H23ClN2O3S
  1
1
EC50 > 33000 nM
 Bioactivity Info 
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CP0552335
 Compound Info 
[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-(2-chloropyridin-3-yl)methanone
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C23H20Cl3N3O
  1
1
EC50 > 33000 nM
 Bioactivity Info 
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CP0565545
 Compound Info 
2-chloro-N-(3-chloro-4-methoxyphenyl)-2,2-difluoro-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]acetamide
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C23H20Cl2F2N2O3S
  1
1
EC50 > 33000 nM
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CP0568517
 Compound Info 
[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-(2,5-difluoro-4-nitrophenyl)methanone
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C24H19Cl2F2N3O3
  1
1
EC50 > 33000 nM
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CP0955514
 Compound Info 
(1R,3R)-methyl 1-(4-(methoxycarbonyl)phenyl)-2-(5-methyl-4-nitroisoxazole-3-carbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
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C26H22N4O8
  1
1
EC50 > 33000 nM
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CP0957136
 Compound Info 
(1R,3R)-methyl 2-(2-chloroacetyl)-1-(4-(methoxycarbonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
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C23H21ClN2O5
  1
1
EC50 > 33000 nM
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CP0479518
 Compound Info 
2-(N-(2-bromo-2-fluoroacetyl)-3-chloro-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide
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C23H21BrClFN2O3S
  1
1
EC50 > 33000 nM
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CP0479519
 Compound Info 
N-(3-chloro-4-methoxyphenyl)-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]-3-tri(propan-2-yl)silylprop-2-ynamide
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C33H41ClN2O3SSi
  1
1
EC50 > 33000 nM
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CP0479520
 Compound Info 
[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-(2-chloro-3-nitrophenyl)methanone
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C24H20Cl3N3O3
  1
1
EC50 > 33000 nM
 Bioactivity Info 
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CP0500341
 Compound Info 
2-chloro-N-(3-chloro-4-methoxyphenyl)-2,3,3,3-tetrafluoro-N-[2-oxo-2-(2-phenylethylamino)-1-thiophen-2-ylethyl]propanamide
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C24H20Cl2F4N2O3S
  1
1
EC50 > 33000 nM
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CP0500343
 Compound Info 
1-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-2-(3-bromo-4,5-dihydro-1,2-oxazol-5-yl)ethanone
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C22H22BrCl2N3O2
  1
1
EC50 > 33000 nM
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CP0512774
 Compound Info 
N-(1,3-benzodioxol-5-yl)-5-methyl-4-nitro-N-[(2-prop-2-enoxyphenyl)methyl]-1,2-oxazole-3-carboxamide
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C22H19N3O7
  1
1
EC50 > 33000 nM
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CP0540504
 Compound Info 
[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-(3-bromo-4,5-dihydro-1,2-oxazol-5-yl)methanone
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C21H20BrCl2N3O2
  1
1
EC50 > 33000 nM
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CP0548274
 Compound Info 
2-(3-chloro-N-(2-chloro-2-fluoroacetyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide
   Show/Hide
C23H21Cl2FN2O3S
  1
1
EC50 > 33000 nM
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CP0565544
 Compound Info 
[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-(2-fluoro-5-nitrophenyl)methanone
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C24H20Cl2FN3O3
  1
1
EC50 > 33000 nM
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CP0571773
 Compound Info 
(5-methyl-4-nitro-1,2-oxazol-3-yl)-(1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)methanone
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C16H14N4O4
  1
1
EC50 > 33000 nM
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CP0952577
 Compound Info 
(1S,3R)-methyl 1-(4-(methoxycarbonyl)phenyl)-2-(5-methyl-4-nitroisoxazole-3-carbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
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C26H22N4O8
  1
1
EC50 > 33000 nM
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CP0266261
 Compound Info 
5-methyl-4-nitro-N-prop-2-ynyl-1,2-oxazole-3-carboxamide
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C8H7N3O4
  1
1
EC50 = 48000 nM
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Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0003433
 Compound Info 
(Arylindolyl)maleimide deriv. 27
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 C21H16N4O2  2
1
GI50 = 2610 nM
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2
LC50 > 100000 nM
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CP0007711
 Compound Info 
(E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]-N'-propylprop-2-enehydrazide;2,2,2-trifluoroacetic acid
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 C26H31F3N4O3  2
1
GI50 = 118 nM
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2
LC50 = 537 nM
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CP0024501
 Compound Info 
(1S,5S,6R,9S,15E,20R)-6-[(2S)-butan-2-yl]-5-hydroxy-20-(2-methylsulfanylethyl)-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetrone
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 C23H37N3O6S3  1
1
GI50 = 2.5 nM
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CP0082019
 Compound Info 
(2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid
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 C22H21NO2S  1
1
GI50 = 6310 nM
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CP0086475
 Compound Info 
2-[(4-methoxyphenyl)-diphenylmethyl]sulfanylethanamine
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 C22H23NOS  1
1
GI50 = 500 nM
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CP0091315
 Compound Info 
US9422297, AAG145-136
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 C17H13ClN4  1
1
GI50 = 308 nM
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CP0176598
 Compound Info 
N-[4-[2-[(2S,3S,5R)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-1,3-dithian-2-yl]phenyl]-N'-hydroxyoctanediamide
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 C34H52N4O7S2Si  1
1
GI50 = 1778.28 nM
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CP0345034
 Compound Info 
[(2R)-1-(4-tert-butylphenoxy)-3-(2-nitroimidazol-1-yl)propan-2-yl] 4-[(2-hydroxy-5-oxocyclopenta-1,3-dien-1-yl)methylideneamino]benzoate
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 C29H28N4O7  1
1
GI50 = 18000 nM
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CP0370065
 Compound Info 
5-(4-chlorophenyl)-2-(4-methoxyphenyl)-[1,3]thiazolo[3,2-b][1,2,4]triazole
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 C17H12ClN3OS  1
1
GI50 > 50000 nM
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CP0451721
 Compound Info 
(1S,7R,10S,16E,21R)-7-benzyl-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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 C26H34N4O6S2  1
1
GI50 = 2.2 nM
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CP0476016
 Compound Info 
1-[4-[1-adamantyl(phenyl)methyl]phenyl]piperazine
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 C27H34N2  2
1
GI50 = 2790 nM
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2
LC50 = 8110 nM
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CP0517268
 Compound Info 
1-[4-[1-adamantyl(phenyl)methyl]phenyl]-4-ethylpiperazine
   Show/Hide
 C29H38N2  2
1
GI50 = 3790 nM
   TI
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2
LC50 = 8400 nM
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CP0554563
 Compound Info 
(1S,10S,16E,21R)-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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 C19H28N4O6S2  1
1
GI50 = 2900 nM
   TI
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CP0565040
 Compound Info 
(1S,7Z,10S,16E,21R)-7-ethylidene-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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 C21H30N4O6S2  1
1
GI50 = 25 nM
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CP0897293
 Compound Info 
1-(7-Benzyl-2-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline hydrochloride
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 C24H25ClN4O  1
1
GI50 = 521 nM
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CP0906523
 Compound Info 
7-Benzyl-N-(4-methoxyphenyl)-N,2,5-trimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine hydrochloride
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 C23H25ClN4O  1
1
GI50 = 58.8 nM
   TI
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Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Lymph node)
Cell Line Name Organism Disease
AN3-CA
 Cell Line Info 
Homo sapiens (Human) Acanthosis nigricans--NCIt; C7359; Endometrial adenocarcinoma
A2058
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
SW620
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
SW620/AD300
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
LoVo
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
SK-MEL-5
 Cell Line Info 
Homo sapiens (Human) Cutaneous melanoma
SU-DHL-5
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
HOC313
 Cell Line Info 
Homo sapiens (Human) Floor of mouth squamous cell carcinoma
HGC-27
 Cell Line Info 
Homo sapiens (Human) Gastric carcinoma
NUGC-4
 Cell Line Info 
Homo sapiens (Human) Gastric signet ring cell adenocarcinoma
NCI-H1993
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
PC-9
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H838
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1568
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
PC9-DRH
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2009
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1299
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
NCI-H1155
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
NCI-H292
 Cell Line Info 
Homo sapiens (Human) Lung mucoepidermoid carcinoma
HBL-2 [Human mantle cell lymphoma]
 Cell Line Info 
Homo sapiens (Human) Mantle cell lymphoma
MNT-1
 Cell Line Info 
Homo sapiens (Human) Melanoma
JR8
 Cell Line Info 
Homo sapiens (Human) Melanoma
MM96L
 Cell Line Info 
Homo sapiens (Human) Melanoma
WM3629
 Cell Line Info 
Homo sapiens (Human) Melanoma
L3.6pl
 Cell Line Info 
Homo sapiens (Human) Pancreatic adenosquamous carcinoma
LNCaP
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
LAPC-4
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
LNCaP-AR
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
LNCaP C4-2
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
MR49F
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
LNCaP-hr
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
LNCap-ARR2PB-eGFP
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
Th17
 Cell Line Info 
Mus musculus (Mouse) -