General Information of the Cell Line
Cell Line ID
CL000303
Cell Line Name
AN3-CA
Synonyms
AN3_CA
AN3 CA
AN3 Ca
AN3CA
AN-3
AN3
Acanthosis Nigricans 3rd attempt-CArcinoma
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0028
Tissue Information
Lymph node
Disease
Acanthosis nigricans--NCIt; C7359; Endometrial adenocarcinoma (NCIt: C26687)
Endometrial adenocarcinoma (NCIt: C7359)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00845, RAC-alpha serine/threonine-protein kinase
 Protein Info 
Compound ID Compound Name Compound Formula
CP0376695
 Compound Info 
N-[[4-[5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]methyl]-3-fluorobenzamide
   Show/Hide
C33H26FN7O2
  3
1
IC50 = 44 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 45 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 220 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405066
 Compound Info 
N-[[4-[2-(2-aminopyridin-3-yl)-6-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]-3-fluorobenzamide
   Show/Hide
C30H22FN7O
  3
1
IC50 = 46 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 49 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 820 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0389476
 Compound Info 
2-[4-[5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]-N-phenylacetamide
   Show/Hide
C33H27N7O2
  3
1
IC50 = 47 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 49 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0453697
 Compound Info 
2-[4-[2-(2-aminopyridin-3-yl)-5-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]-N-phenylacetamide
   Show/Hide
C30H23N7O
  3
1
IC50 = 51 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 69 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 2500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0441192
 Compound Info 
N-[[4-[2-(2-aminopyridin-3-yl)-6-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamide
   Show/Hide
C30H23N7O
  3
1
IC50 = 80 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 91 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397465
 Compound Info 
2-[4-[5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]-N-(3-fluorophenyl)acetamide
   Show/Hide
C33H26FN7O2
  3
1
IC50 = 90 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 260 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0376644
 Compound Info 
N-[[4-[2-(2-aminopyridin-3-yl)-5-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]-3-fluorobenzamide
   Show/Hide
C30H22FN7O
  3
1
IC50 = 95 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 340 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0376692
 Compound Info 
N-[[4-[5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamide
   Show/Hide
C33H27N7O2
  3
1
IC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 170 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 840 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0441194
 Compound Info 
N-[[4-[2-(2-aminopyridin-3-yl)-6-phenylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamide
   Show/Hide
C31H24N6O
  3
1
IC50 = 160 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 980 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 1100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397469
 Compound Info 
N-[[4-[2-(2-aminopyridin-3-yl)-5-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamide
   Show/Hide
C30H23N7O
  3
1
IC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 3200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 4200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0024409
 Compound Info 
2-[4-[2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]-N-phenylacetamide
   Show/Hide
C25H20N6O
  2
1
IC50 = 2500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0389516
 Compound Info 
N-[[4-[2-(2-aminopyridin-3-yl)-6-bromoimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamide
   Show/Hide
C25H19BrN6O
  2
1
IC50 = 2500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397464
 Compound Info 
N-[[4-[2-(2-aminopyridin-3-yl)-6-cyclopentylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamide
   Show/Hide
C30H28N6O
  3
1
IC50 = 3700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 9400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0022681
 Compound Info 
N-[[4-[2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamide
   Show/Hide
C25H20N6O
  2
1
IC50 = 5600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0389475
 Compound Info 
N-[[4-[2-(2-aminopyridin-3-yl)-5-phenylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamide
   Show/Hide
C31H24N6O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0024409
 Compound Info 
2-[4-[2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]-N-phenylacetamide
   Show/Hide
 C25H20N6O  1
1
IC50 = 70000 nM
   TI
   LI
   LO
   TS
CP0112599
 Compound Info 
US8569511, 2
   Show/Hide
 C23H22F2N6O2  1
1
IC50 < 30 nM
   TI
   LI
   LO
   TS
CP0376644
 Compound Info 
N-[[4-[2-(2-aminopyridin-3-yl)-5-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]-3-fluorobenzamide
   Show/Hide
 C30H22FN7O  1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0376692
 Compound Info 
N-[[4-[5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamide
   Show/Hide
 C33H27N7O2  1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0376695
 Compound Info 
N-[[4-[5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]methyl]-3-fluorobenzamide
   Show/Hide
 C33H26FN7O2  1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0389476
 Compound Info 
2-[4-[5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]-N-phenylacetamide
   Show/Hide
 C33H27N7O2  1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0389516
 Compound Info 
N-[[4-[2-(2-aminopyridin-3-yl)-6-bromoimidazo[4,5-b]pyridin-3-yl]phenyl]methyl]benzamide
   Show/Hide
 C25H19BrN6O  1
1
IC50 = 60000 nM
   TI
   LI
   LO
   TS
CP0453697
 Compound Info 
2-[4-[2-(2-aminopyridin-3-yl)-5-pyridin-3-ylimidazo[4,5-b]pyridin-3-yl]phenyl]-N-phenylacetamide
   Show/Hide
 C30H23N7O  1
1
IC50 = 8800 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Lymph node)
Cell Line Name Organism Disease
A2058
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
LOX-IMVI
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
SW620
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
SW620/AD300
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
LoVo
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
SK-MEL-5
 Cell Line Info 
Homo sapiens (Human) Cutaneous melanoma
SU-DHL-5
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
HOC313
 Cell Line Info 
Homo sapiens (Human) Floor of mouth squamous cell carcinoma
HGC-27
 Cell Line Info 
Homo sapiens (Human) Gastric carcinoma
NUGC-4
 Cell Line Info 
Homo sapiens (Human) Gastric signet ring cell adenocarcinoma
NCI-H1993
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
PC-9
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H838
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1568
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
PC9-DRH
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2009
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1299
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
NCI-H1155
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
NCI-H292
 Cell Line Info 
Homo sapiens (Human) Lung mucoepidermoid carcinoma
HBL-2 [Human mantle cell lymphoma]
 Cell Line Info 
Homo sapiens (Human) Mantle cell lymphoma
MNT-1
 Cell Line Info 
Homo sapiens (Human) Melanoma
JR8
 Cell Line Info 
Homo sapiens (Human) Melanoma
MM96L
 Cell Line Info 
Homo sapiens (Human) Melanoma
WM3629
 Cell Line Info 
Homo sapiens (Human) Melanoma
L3.6pl
 Cell Line Info 
Homo sapiens (Human) Pancreatic adenosquamous carcinoma
LNCaP
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
LAPC-4
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
LNCaP-AR
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
LNCaP C4-2
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
MR49F
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
LNCaP-hr
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
LNCap-ARR2PB-eGFP
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
Th17
 Cell Line Info 
Mus musculus (Mouse) -