General Information of the Cell Line
Cell Line ID
CL000095
Cell Line Name
NCI-H1299
Synonyms
H1299
H-1299
NCIH1299
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0060
Tissue Information
Lymph node
Disease
Lung large cell carcinoma (NCIt: C4450)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01462, Bromodomain-containing protein 4
Compound ID Compound Name Compound Formula
CP0482696
N-(12-chloro-23-methyl-22-oxo-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-4-yl)ethanesulfonamide
   Show/Hide
C24H25ClN2O5S
 1
1
EC50 = 5.1 nM
   TI
   LI
   LO
   TS
CP0538674
N-(10,12-difluoro-23-methyl-22-oxo-8,19-dioxa-6,23-diazatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-4-yl)ethanesulfonamide
   Show/Hide
C23H23F2N3O5S
 1
1
EC50 = 6.4 nM
   TI
   LI
   LO
   TS
CP0538673
N-(10,12-difluoro-23-methyl-22-oxo-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-4-yl)ethanesulfonamide
   Show/Hide
C24H24F2N2O5S
 1
1
EC50 = 6.5 nM
   TI
   LI
   LO
   TS
CP0567176
4-ethylsulfonyl-23-methyl-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9,11,13,20-octaen-22-one
   Show/Hide
C24H25NO5S
 1
1
EC50 = 6.7 nM
   TI
   LI
   LO
   TS
CP0106552
US9296741, 21
   Show/Hide
C22H21N3O4S
 1
1
EC50 = 8.1 nM
   TI
   LI
   LO
   TS
CP0567179
N-(12-chloro-23-methyl-22-oxo-8,19-dioxa-6,23-diazatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-4-yl)ethanesulfonamide
   Show/Hide
C23H24ClN3O5S
 1
1
EC50 = 9.3 nM
   TI
   LI
   LO
   TS
CP0120224
US9296741, 4
   Show/Hide
C21H19N3O4S
 1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0202074
12-chloro-4-ethylsulfonyl-23-methyl-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-22-one
   Show/Hide
C24H24ClNO5S
 1
1
EC50 = 16 nM
   TI
   LI
   LO
   TS
CP0369516
N-[4-(4-chlorophenoxy)-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide
   Show/Hide
C22H20ClN3O4S
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0227160
US9296741, 57
   Show/Hide
C21H25N3O4S
 1
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0543503
12-chloro-23-methyl-4-(methylsulfonylmethyl)-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-22-one
   Show/Hide
C24H24ClNO5S
 1
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0153834
US9296741, 62
   Show/Hide
C22H18F3N3O4S
 1
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
CP0069311
US10633379, Compound X
   Show/Hide
C22H19F2N3O4S
 2
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0244069
US9296741, 59
   Show/Hide
C21H23F2N3O4S
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0217104
US9296741, 27
   Show/Hide
C21H17F2N3O4S
 1
1
EC50 = 21 nM
   TI
   LI
   LO
   TS
CP0326185
US9296741, 5
   Show/Hide
C22H18F3N3O4S
 1
1
EC50 = 22 nM
   TI
   LI
   LO
   TS
CP0511722
12-chloro-23-methyl-4-(methylsulfonylmethyl)-8,19-dioxa-6,23-diazatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-22-one
   Show/Hide
C23H23ClN2O5S
 1
1
EC50 = 24 nM
   TI
   LI
   LO
   TS
CP0244064
US9296741, 6
   Show/Hide
C22H19N3O3
 1
1
EC50 = 26 nM
   TI
   LI
   LO
   TS
CP0562948
4-ethylsulfonyl-22-methyl-8,18-dioxa-22-azatetracyclo[17.4.0.02,7.09,14]tricosa-1(23),2(7),3,5,9,11,13,19-octaen-21-one
   Show/Hide
C23H23NO5S
 1
1
EC50 = 26 nM
   TI
   LI
   LO
   TS
CP0477221
N-[4-(4-chlorophenoxy)-3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide
   Show/Hide
C22H23ClN2O5S
 1
1
EC50 = 27 nM
   TI
   LI
   LO
   TS
CP0567270
12-chloro-4-ethylsulfonyl-23-methyl-8,19-dioxa-6,23-diazatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-22-one
   Show/Hide
C23H23ClN2O5S
 1
1
EC50 = 34 nM
   TI
   LI
   LO
   TS
CP0347240
US9296741, 34
   Show/Hide
C21H17ClFN3O4S
 1
1
EC50 = 35 nM
   TI
   LI
   LO
   TS
CP0423161
N-(12-chloro-24-methyl-23-oxo-8,20-dioxa-24-azatetracyclo[19.4.0.02,7.09,14]pentacosa-1(25),2(7),3,5,9(14),10,12,21-octaen-4-yl)ethanesulfonamide
   Show/Hide
C25H27ClN2O5S
 1
1
EC50 = 35 nM
   TI
   LI
   LO
   TS
CP0198214
US9296741, 95
   Show/Hide
C20H17N3O4S
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0437285
N-[4-(2,4-difluorophenoxy)-3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide
   Show/Hide
C22H22F2N2O5S
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0477220
N-[3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)-4-phenoxyphenyl]ethanesulfonamide
   Show/Hide
C22H24N2O5S
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0236547
3-[2-(2,4-difluorophenoxy)-5-(methylsulfonylmethyl)phenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one
   Show/Hide
C22H18F2N2O4S
 1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0131103
US9296741, 22
   Show/Hide
C22H22N4O4S
 1
1
EC50 = 43 nM
   TI
   LI
   LO
   TS
CP0408390
N-[6-(2,4-difluorophenoxy)-5-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)pyridin-3-yl]ethanesulfonamide
   Show/Hide
C21H21F2N3O5S
 1
1
EC50 = 45 nM
   TI
   LI
   LO
   TS
CP0072563
N-[4-(2,4-difluorophenoxy)-3-(1-methyl-7-oxo-6H-pyrrolo[2,3-c]pyridin-3-yl)phenyl]methanesulfonamide
   Show/Hide
C21H17F2N3O4S
 1
1
EC50 = 46 nM
   TI
   LI
   LO
   TS
CP0311314
N-[4-(4-fluorophenoxy)-3-(1-methyl-7-oxo-6H-pyrrolo[2,3-c]pyridin-3-yl)phenyl]ethanesulfonamide
   Show/Hide
C22H20FN3O4S
 1
1
EC50 = 47 nM
   TI
   LI
   LO
   TS
CP0199479
US9296741, 90
   Show/Hide
C23H20N4O4S
 1
1
EC50 = 48 nM
   TI
   LI
   LO
   TS
CP0494506
N-[4-(2,4-difluorophenoxy)-3-[1-methyl-4-(oxetan-3-yloxy)-6-oxopyridin-3-yl]phenyl]ethanesulfonamide
   Show/Hide
C23H22F2N2O6S
 1
1
EC50 = 48 nM
   TI
   LI
   LO
   TS
CP0355322
US9296741, 85
   Show/Hide
C21H18N2O4S
 1
1
EC50 = 50 nM
   TI
   LI
   LO
   TS
CP0082466
N-[3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindol-1-yl)-4-phenoxyphenyl]methanesulfonamide
   Show/Hide
C22H22N2O4S
 1
1
EC50 = 51 nM
   TI
   LI
   LO
   TS
CP0539347
N-[4-(4-cyanophenoxy)-3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide
   Show/Hide
C23H23N3O5S
 1
1
EC50 = 55 nM
   TI
   LI
   LO
   TS
CP0326282
N-[4-(2,4-difluorophenoxy)-3-(1-methyl-7-oxo-6H-pyrrolo[2,3-c]pyridin-3-yl)phenyl]ethanesulfonamide
   Show/Hide
C22H19F2N3O4S
 1
1
EC50 = 56 nM
   TI
   LI
   LO
   TS
CP0404514
N-[4-(2,4-difluorophenoxy)-3-(4-methoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide
   Show/Hide
C21H20F2N2O5S
 1
1
EC50 = 56 nM
   TI
   LI
   LO
   TS
CP0199478
N-[3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-[4-(trifluoromethyl)phenoxy]phenyl]ethanesulfonamide
   Show/Hide
C23H20F3N3O4S
 1
1
EC50 = 65 nM
   TI
   LI
   LO
   TS
CP0538672
5-[2-(2,4-difluorophenoxy)-5-ethylsulfonylphenyl]-4-ethoxy-1-methylpyridin-2-one
   Show/Hide
C22H21F2NO5S
 1
1
EC50 = 66 nM
   TI
   LI
   LO
   TS
CP0263573
US9296741, 11
   Show/Hide
C20H18N4O4S
 1
1
EC50 = 67 nM
   TI
   LI
   LO
   TS
CP0562947
N-[3-(4-methoxy-1-methyl-6-oxopyridin-3-yl)-4-phenoxyphenyl]ethanesulfonamide
   Show/Hide
C21H22N2O5S
 1
1
EC50 = 67 nM
   TI
   LI
   LO
   TS
CP0567268
N-[3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)-4-(4-fluorophenoxy)phenyl]ethanesulfonamide
   Show/Hide
C22H23FN2O5S
 1
1
EC50 = 69 nM
   TI
   LI
   LO
   TS
CP0286070
US9296741, 13
   Show/Hide
C23H21N3O3
 1
1
EC50 = 70 nM
   TI
   LI
   LO
   TS
CP0265296
US9296741, 19
   Show/Hide
C21H17N3O3
 1
1
EC50 = 71 nM
   TI
   LI
   LO
   TS
CP0102233
N-[4-(2,4-difluorophenoxy)-3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindol-1-yl)phenyl]methanesulfonamide
   Show/Hide
C22H20F2N2O4S
 1
1
EC50 = 75 nM
   TI
   LI
   LO
   TS
CP0326283
N-[3-(7-methyl-1-oxo-2,6-dihydropyrrolo[3,4-d]pyridazin-5-yl)-4-phenoxyphenyl]ethanesulfonamide
   Show/Hide
C21H20N4O4S
 1
1
EC50 = 75 nM
   TI
   LI
   LO
   TS
CP0566085
N-[3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-[2-(trifluoromethyl)phenoxy]phenyl]methanesulfonamide
   Show/Hide
C22H18F3N3O4S
 1
1
EC50 = 76 nM
   TI
   LI
   LO
   TS
CP0567174
N-[3-(4-methoxy-1-methyl-6-oxopyridin-3-yl)-4-phenoxyphenyl]methanesulfonamide
   Show/Hide
C20H20N2O5S
 1
1
EC50 = 77 nM
   TI
   LI
   LO
   TS
CP0325482
US9296741, 144
   Show/Hide
C21H27N3O4S
 1
1
EC50 = 79 nM
   TI
   LI
   LO
   TS
CP0131105
US9296741, 23
   Show/Hide
C20H18N4O4S
 1
1
EC50 = 88 nM
   TI
   LI
   LO
   TS
CP0198210
US9296741, 29
   Show/Hide
C20H23N3O5S
 1
1
EC50 = 90 nM
   TI
   LI
   LO
   TS
CP0536109
1-methyl-3-(5-methylsulfonyl-2-phenoxyphenyl)-6H-pyrrolo[2,3-c]pyridin-7-one
   Show/Hide
C21H18N2O4S
 1
1
EC50 = 91 nM
   TI
   LI
   LO
   TS
CP0389294
N-[4-(2,4-difluorophenoxy)-3-[1-methyl-6-oxo-4-(2,2,2-trifluoroethoxy)pyridin-3-yl]phenyl]ethanesulfonamide
   Show/Hide
C22H19F5N2O5S
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0244071
US9296741, 63
   Show/Hide
C22H21N3O4S
 1
1
EC50 = 120 nM
   TI
   LI
   LO
   TS
CP0078527
N-[3-(3-methyl-4-oxo-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-1-yl)-4-phenoxyphenyl]methanesulfonamide
   Show/Hide
C21H21N3O4S
 1
1
EC50 = 120 nM
   TI
   LI
   LO
   TS
CP0408389
N-[4-(2,4-difluorophenoxy)-3-[4-(ethylamino)-1-methyl-6-oxopyridin-3-yl]phenyl]ethanesulfonamide
   Show/Hide
C22H23F2N3O4S
 1
1
EC50 = 140 nM
   TI
   LI
   LO
   TS
CP0227914
3-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one
   Show/Hide
C21H16F2N2O4S
 1
1
EC50 = 150 nM
   TI
   LI
   LO
   TS
CP0408387
N-[3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)-4-pyridin-3-yloxyphenyl]ethanesulfonamide
   Show/Hide
C21H23N3O5S
 1
1
EC50 = 150 nM
   TI
   LI
   LO
   TS
CP0004236
(+)-JQ1
   Show/Hide
C23H25ClN4O2S
 1
1
EC50 = 153 nM
   TI
   LI
   LO
   TS
CP0217103
US9296741, 141
   Show/Hide
C20H19N5O4S
 1
1
EC50 = 170 nM
   TI
   LI
   LO
   TS
CP0326285
N-[3-(7-methyl-1-oxo-2,6-dihydropyrrolo[3,4-d]pyridazin-5-yl)-4-phenoxyphenyl]methanesulfonamide
   Show/Hide
C20H18N4O4S
 1
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
CP0408388
N-[4-(2,4-difluorophenoxy)-3-[1-methyl-4-(2-methylpropoxy)-6-oxopyridin-3-yl]phenyl]ethanesulfonamide
   Show/Hide
C24H26F2N2O5S
 1
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
CP0408386
N-[3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)-4-[4-(trifluoromethoxy)phenoxy]phenyl]ethanesulfonamide
   Show/Hide
C23H23F3N2O6S
 1
1
EC50 = 210 nM
   TI
   LI
   LO
   TS
CP0078526
7-methyl-5-(2-phenoxyphenyl)-2,6-dihydropyrrolo[3,4-d]pyridazin-1-one
   Show/Hide
C19H15N3O2
 1
1
EC50 = 220 nM
   TI
   LI
   LO
   TS
CP0539327
5-[2-(2,4-difluorophenoxy)-5-(methylsulfonylmethyl)phenyl]-4-ethoxy-1-methylpyridin-2-one
   Show/Hide
C22H21F2NO5S
 1
1
EC50 = 230 nM
   TI
   LI
   LO
   TS
CP0558506
N-[3-(4-methoxy-1-methyl-6-oxopyridazin-3-yl)-4-phenoxyphenyl]methanesulfonamide
   Show/Hide
C19H19N3O5S
 1
1
EC50 = 230 nM
   TI
   LI
   LO
   TS
CP0237899
N-[4-[4-(dimethylamino)cyclohexyl]oxy-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide
   Show/Hide
C24H32N4O4S
 1
1
EC50 = 270 nM
   TI
   LI
   LO
   TS
CP0072566
3-methyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one
   Show/Hide
C21H19NO2
 1
1
EC50 = 280 nM
   TI
   LI
   LO
   TS
CP0078524
N-[4-(2,4-difluorophenoxy)-3-(7-methyl-1-oxo-2,6-dihydropyrrolo[3,4-d]pyridazin-5-yl)phenyl]methanesulfonamide
   Show/Hide
C20H16F2N4O4S
 1
1
EC50 = 280 nM
   TI
   LI
   LO
   TS
CP0356978
3-methyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-4-one
   Show/Hide
C20H18N2O2
 1
1
EC50 = 280 nM
   TI
   LI
   LO
   TS
CP0558974
5-[2-(4-chlorophenoxy)phenyl]-2-methyl-1H-pyrrole-3-carboxamide
   Show/Hide
C18H15ClN2O2
 1
1
EC50 = 280 nM
   TI
   LI
   LO
   TS
CP0102231
1-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-3-methyl-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-4-one
   Show/Hide
C21H18F2N2O4S
 1
1
EC50 = 290 nM
   TI
   LI
   LO
   TS
CP0102234
1-(5-amino-2-phenoxyphenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one
   Show/Hide
C21H20N2O2
 1
1
EC50 = 300 nM
   TI
   LI
   LO
   TS
CP0567267
N-[3-(4-methoxy-1-methyl-6-oxopyridazin-3-yl)-4-phenoxyphenyl]acetamide
   Show/Hide
C20H19N3O4
 1
1
EC50 = 370 nM
   TI
   LI
   LO
   TS
CP0437005
N-[4-(4,4-difluorocyclohexyl)oxy-3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide
   Show/Hide
C22H28F2N2O5S
 1
1
EC50 = 390 nM
   TI
   LI
   LO
   TS
CP0571581
N-[3-(5-methyl-4-oxo-3,6-dihydropyrrolo[3,4-d]pyrimidin-7-yl)-4-phenoxyphenyl]methanesulfonamide
   Show/Hide
C20H18N4O4S
 1
1
EC50 = 410 nM
   TI
   LI
   LO
   TS
CP0468714
N-[4-(2,4-difluorophenoxy)-3-(3-methyl-4-oxo-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-1-yl)phenyl]methanesulfonamide
   Show/Hide
C21H19F2N3O4S
 1
1
EC50 = 420 nM
   TI
   LI
   LO
   TS
CP0359971
2-methyl-5-(2-phenoxyphenyl)-1H-pyrrole-3-carboxamide
   Show/Hide
C18H16N2O2
 1
1
EC50 = 450 nM
   TI
   LI
   LO
   TS
CP0093431
US9296741, 1
   Show/Hide
C20H16N2O2
 1
1
EC50 = 480 nM
   TI
   LI
   LO
   TS
CP0567175
4-ethylsulfonyl-21-methyl-8,17-dioxa-21-azatetracyclo[16.4.0.02,7.09,14]docosa-1(22),2(7),3,5,9,11,13,18-octaen-20-one
   Show/Hide
C22H21NO5S
 1
1
EC50 = 630 nM
   TI
   LI
   LO
   TS
CP0308317
3-methyl-1-(2-phenoxyphenyl)-2,5-dihydropyrrolo[3,4-c]pyridin-4-one
   Show/Hide
C20H16N2O2
 1
1
EC50 = 700 nM
   TI
   LI
   LO
   TS
CP0308316
5-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-7-methyl-2,6-dihydropyrrolo[3,4-d]pyridazin-1-one
   Show/Hide
C20H15F2N3O4S
 1
1
EC50 = 750 nM
   TI
   LI
   LO
   TS
CP0548979
N-[3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-(1-methylpiperidin-4-yl)oxyphenyl]ethanesulfonamide
   Show/Hide
C22H28N4O4S
 1
1
EC50 = 880 nM
   TI
   LI
   LO
   TS
CP0308318
5-(5-amino-2-phenoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide
   Show/Hide
C18H17N3O2
 1
1
EC50 = 880 nM
   TI
   LI
   LO
   TS
CP0308310
1-methyl-3-(2-phenoxyphenyl)-6H-pyrrolo[2,3-c]pyridin-7-one
   Show/Hide
C20H16N2O2
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0509625
N-[4-(2,4-difluorophenoxy)-3-[4-(2-hydroxy-2-methylpropoxy)-1-methyl-6-oxopyridin-3-yl]phenyl]ethanesulfonamide
   Show/Hide
C24H26F2N2O6S
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0224571
5-[5-(methanesulfonamido)-2-phenoxyphenyl]-2-methyl-1H-pyrrole-3-carboxamide
   Show/Hide
C19H19N3O4S
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0536108
N-ethyl-3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindol-1-yl)-4-phenoxybenzamide
   Show/Hide
C24H24N2O3
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0566098
1-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-3-methyl-2,5,6,7-tetrahydroisoindol-4-one
   Show/Hide
C22H19F2NO4S
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0261379
5-methyl-7-(2-phenoxyphenyl)-3,6-dihydropyrrolo[3,4-d]pyrimidin-4-one
   Show/Hide
C19H15N3O2
 1
1
EC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0536107
US9776990, Example 53
   Show/Hide
C23H21NO4
 1
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0536106
5-(2-amino-6-phenoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide
   Show/Hide
C18H17N3O2
 1
1
EC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0567269
N-[4-(2,4-difluorophenoxy)-3-[1-methyl-4-(2-morpholin-4-ylethoxy)-6-oxopyridin-3-yl]phenyl]ethanesulfonamide
   Show/Hide
C26H29F2N3O6S
 1
1
EC50 = 2200 nM
   TI
   LI
   LO
   TS
CP0563514
3-methyl-5-(2-phenoxyphenyl)-1H-pyridin-2-one
   Show/Hide
C18H15NO2
 1
1
EC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0475376
5-[2-(2,4-difluorophenoxy)-5-(methanesulfonamido)phenyl]-2-methyl-1H-pyrrole-3-carboxamide
   Show/Hide
C19H17F2N3O4S
 1
1
EC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0308319
5-(2-anilinophenyl)-2-methyl-1H-pyrrole-3-carboxamide
   Show/Hide
C18H17N3O
 1
1
EC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0482694
1-ethyl-3-[3-(4-methoxy-1-methyl-6-oxopyridazin-3-yl)-4-phenoxyphenyl]urea
   Show/Hide
C21H22N4O4
 1
1
EC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0509624
4-methoxy-1-methyl-5-(2-phenoxyphenyl)pyridin-2-one
   Show/Hide
C19H17NO3
 1
1
EC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0494505
6-(5-amino-2-phenoxyphenyl)-5-methoxy-2-methylpyridazin-3-one
   Show/Hide
C18H17N3O3
 1
1
EC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0408385
5-methoxy-2-methyl-6-(2-phenoxyphenyl)pyridazin-3-one
   Show/Hide
C18H16N2O3
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0198216
1-methyl-5-(2-phenoxyphenyl)pyridin-2-one
   Show/Hide
C18H15NO2
 1
1
EC50 = 4100 nM
   TI
   LI
   LO
   TS
CP0356979
5-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-2-methyl-1H-pyrrole-3-carboxamide
   Show/Hide
C19H16F2N2O4S
 1
1
EC50 = 4500 nM
   TI
   LI
   LO
   TS
CP0538671
ethyl N-[3-(4-methoxy-1-methyl-6-oxopyridazin-3-yl)-4-phenoxyphenyl]carbamate
   Show/Hide
C21H21N3O5
 1
1
EC50 = 4900 nM
   TI
   LI
   LO
   TS
CP0072567
1-(2-aminophenyl)-3-methyl-2,5,6,7-tetrahydro-4H-isoindol-4-one
   Show/Hide
C15H16N2O
 1
1
EC50 = 7100 nM
   TI
   LI
   LO
   TS
CP0244065
3-amino-1-methyl-5-(2-phenoxyphenyl)pyridin-2-one
   Show/Hide
C18H16N2O2
 1
1
EC50 = 8500 nM
   TI
   LI
   LO
   TS
CP0261380
5-(2-aminophenyl)-2-methyl-1H-pyrrole-3-carboxamide
   Show/Hide
C12H13N3O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0387151
8-(4-fluorophenyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C23H20FN3O3S
 1
1
IC50 = 1.5 nM
   TI
   LI
   LO
   TS
CP0069317
15-methyl-4-(methylsulfonylmethyl)-8-pyridin-2-yl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C22H20N4O3S
 1
1
IC50 = 1.7 nM
   TI
   LI
   LO
   TS
CP0219122
12-methyl-4-(methylsulfonylmethyl)-8-pyridin-2-yl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C22H20N4O3S
 1
1
IC50 = 2.3 nM
   TI
   LI
   LO
   TS
CP0069319
8-(4-fluorophenyl)-12-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C23H20FN3O3S
 1
1
IC50 = 2.5 nM
   TI
   LI
   LO
   TS
CP0069312
8-(2,4-difluorophenyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C23H19F2N3O3S
 1
1
IC50 = 3.6 nM
   TI
   LI
   LO
   TS
CP0542881
8-(4,4-difluorocyclohexyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C23H25F2N3O3S
 1
1
IC50 = 3.7 nM
   TI
   LI
   LO
   TS
CP0429554
N-[8-(2,4-difluorophenyl)-15-methyl-14-oxo-6,8,12,15-tetrazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-4-yl]ethanesulfonamide
   Show/Hide
C22H19F2N5O3S
 1
1
IC50 = 4.1 nM
   TI
   LI
   LO
   TS
CP0542880
N-[8-(4-fluorophenyl)-12-methyl-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-4-yl]ethanesulfonamide
   Show/Hide
C23H21FN4O3S
 1
1
IC50 = 4.3 nM
   TI
   LI
   LO
   TS
CP0368355
8-(cyclopropylmethyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C21H23N3O3S
 1
1
IC50 = 4.6 nM
   TI
   LI
   LO
   TS
CP0148525
8-(2,4-difluorophenyl)-12-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C23H19F2N3O3S
 1
1
IC50 = 6.5 nM
   TI
   LI
   LO
   TS
CP0320208
15-methyl-4-(methylsulfonylmethyl)-8-propanoyl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C20H21N3O4S
 1
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
CP0514936
N-(12-methyl-14-oxo-8-pyridin-2-yl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-4-yl)ethanesulfonamide
   Show/Hide
C22H21N5O3S
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0219124
US9296741, 329
   Show/Hide
C19H21N3O3S
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0320209
8-(cyclopropanecarbonyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C21H21N3O4S
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0148529
8-(cyclopropylmethyl)-15-methyl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2,4,6,10,13(17)-hexaen-14-one
   Show/Hide
C19H19N3O
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0515982
8-(cyclopropylmethyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.014,17]heptadeca-1(16),2(7),3,5,10,14(17)-hexaen-13-one
   Show/Hide
C21H23N3O3S
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0219123
8-(cyclopropylmethyl)-15-methyl-4-methylsulfonyl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C20H21N3O3S
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0578000
8-(cyclopropanecarbonyl)-12-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one
   Show/Hide
C21H21N3O4S
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0317868
N-[8-(2,4-difluorophenyl)-12-methyl-14-oxo-6,8,12,15-tetrazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-4-yl]ethanesulfonamide
   Show/Hide
C22H19F2N5O3S
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0148526
methyl 12-methyl-4-(methylsulfonylmethyl)-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaene-8-carboxylate
   Show/Hide
C19H19N3O5S
 1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CP0069313
US9296741, 328
   Show/Hide
C20H23N3O3S
 1
1
IC50 = 58 nM
   TI
   LI
   LO
   TS
CP0148528
8-(cyclopropylmethyl)-15-methyl-8,12,15-triazatetracyclo[8.6.1.02,7.014,17]heptadeca-1(16),2,4,6,10,14(17)-hexaen-13-one
   Show/Hide
C19H19N3O
 1
1
IC50 = 95 nM
   TI
   LI
   LO
   TS
CP0515981
3-[2-(cyclopropylmethylamino)-5-methylsulfonylphenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one
   Show/Hide
C19H21N3O3S
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0148527
8-(cyclopropylmethyl)-15-methyl-4-methylsulfonyl-8,12,15-triazatetracyclo[8.6.1.02,7.014,17]heptadeca-1(16),2(7),3,5,10,14(17)-hexaen-13-one
   Show/Hide
C20H21N3O3S
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0368354
3-[2-(cyclopropylmethylamino)-5-(methylsulfonylmethyl)phenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one
   Show/Hide
C20H23N3O3S
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0097771
US9296741, 352
   Show/Hide
C18H19N3O
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0219126
3-[2-(cyclopropylmethylamino)phenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one
   Show/Hide
C18H19N3O
 1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0013877
CERITINIB
   Show/Hide
C28H36ClN5O3S  1
1
IC50 = 2920 nM
   TI
   LI
   LO
   TS
CP0137899
US10633379, Example 35
   Show/Hide
C28H30FN3O4  1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0363306
3-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-1-yl]-N-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxymethyl]propanamide
   Show/Hide
C51H64ClN9O11S  1
1
IC50 = 2840 nM
   TI
   LI
   LO
   TS
CP0372634
5-(3-Chloro-furan-2-yl)-3-(4-trifluoromethyl-phenyl)-[1,2,4]oxadiazole
   Show/Hide
C13H6ClF3N2O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0372681
5-Chloro-2-[5-(3-chloro-furan-2-yl)-[1,2,4]oxadiazol-3-yl]-pyridine
   Show/Hide
C11H5Cl2N3O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0391548
5-(3-Bromo-furan-2-yl)-3-(4-chloro-phenyl)-[1,2,4]oxadiazole
   Show/Hide
C12H6BrClN2O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0392172
5-(3-Bromo-thiophen-2-yl)-3-(4-chloro-phenyl)-[1,2,4]oxadiazole
   Show/Hide
C12H6BrClN2OS  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0392180
3-(4-Chloro-phenyl)-5-(3-chloro-thiophen-2-yl)-[1,2,4]oxadiazole
   Show/Hide
C12H6Cl2N2OS  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0392290
5-(3-Chloro-furan-2-yl)-3-(4-chloro-phenyl)-[1,2,4]oxadiazole
   Show/Hide
C12H6Cl2N2O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0404841
2-[5-(3-Bromo-furan-2-yl)-[1,2,4]oxadiazol-3-yl]-5-chloro-pyridine
   Show/Hide
C11H5BrClN3O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0417038
6-(2,6-dichlorophenyl)-2-[4-(4-methylpiperazin-1-yl)anilino]-8-phenylpyrido[2,3-d]pyrimidin-5-one
   Show/Hide
C30H26Cl2N6O  1
1
EC50 = 500 nM
   TI
   LI
   LO
   TS
CP0425982
7-(2-chloro-6-fluorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
   Show/Hide
C26H23ClFN7O  1
1
EC50 = 310 nM
   TI
   LI
   LO
   TS
CP0461497
5-Chloro-2-[5-(3-chloro-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-pyridine
   Show/Hide
C11H5Cl2N3OS  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0464649
5-(3-Chloro-thiophen-2-yl)-3-(4-trifluoromethyl-phenyl)-[1,2,4]oxadiazole
   Show/Hide
C13H6ClF3N2OS  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0470469
4-(4-chlorophenyl)-N-[3-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]pyrimidin-2-amine
   Show/Hide
C23H26ClN5O  1
1
GI50 = 5780 nM
   TI
   LI
   LO
   TS
CP0484668
2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethyl 6-[(2E)-2-[(2E,4E,6E)-7-(1-butyl-3,3-dimethylindol-1-ium-2-yl)hepta-2,4,6-trienylidene]-3,3-dimethyl-5-(trifluoromethyl)indol-1-yl]hexanoate;bromide
   Show/Hide
C59H65BrF3N5O5  1
1
IC50 = 541 nM
   TI
   LI
   LO
   TS
CP0497086
2-[5-(3-Chloro-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-5-trifluoromethyl-pyridine
   Show/Hide
C12H5ClF3N3OS  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0536595
7-(2-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
   Show/Hide
C25H23ClN8O  1
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0560122
6-(2,6-dichlorophenyl)-8-methyl-2-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]pyrido[2,3-d]pyrimidin-5-one
   Show/Hide
C26H23Cl2N5O  1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0560735
2-chloro-1-[2,4-diamino-6-[2-(2-methoxyphenyl)ethyl]-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-5-yl]ethanone
   Show/Hide
C18H22ClN5O2  1
1
IC50 = 660 nM
   TI
   LI
   LO
   TS
CP0562543
6-(2,6-dichlorophenyl)-8-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-5-one
   Show/Hide
C25H24Cl2N6O  1
1
EC50 = 520 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Lymph node)
Cell Line Name Organism Disease
AN3-CA Homo sapiens (Human) Acanthosis nigricans--NCIt; C7359; Endometrial adenocarcinoma
A2058 Homo sapiens (Human) Amelanotic melanoma
LOX-IMVI Homo sapiens (Human) Amelanotic melanoma
SW620 Homo sapiens (Human) Colon adenocarcinoma
SW620/AD300 Homo sapiens (Human) Colon adenocarcinoma
LoVo Homo sapiens (Human) Colon adenocarcinoma
SK-MEL-5 Homo sapiens (Human) Cutaneous melanoma
SU-DHL-5 Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
HOC313 Homo sapiens (Human) Floor of mouth squamous cell carcinoma
HGC-27 Homo sapiens (Human) Gastric carcinoma
NUGC-4 Homo sapiens (Human) Gastric signet ring cell adenocarcinoma
NCI-H1993 Homo sapiens (Human) Lung adenocarcinoma
PC-9 Homo sapiens (Human) Lung adenocarcinoma
NCI-H838 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1568 Homo sapiens (Human) Lung adenocarcinoma
PC9-DRH Homo sapiens (Human) Lung adenocarcinoma
NCI-H2009 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1155 Homo sapiens (Human) Lung large cell carcinoma
NCI-H292 Homo sapiens (Human) Lung mucoepidermoid carcinoma
HBL-2 [Human mantle cell lymphoma] Homo sapiens (Human) Mantle cell lymphoma
MNT-1 Homo sapiens (Human) Melanoma
JR8 Homo sapiens (Human) Melanoma
MM96L Homo sapiens (Human) Melanoma
WM3629 Homo sapiens (Human) Melanoma
L3.6pl Homo sapiens (Human) Pancreatic adenosquamous carcinoma
LNCaP Homo sapiens (Human) Prostate carcinoma
LAPC-4 Homo sapiens (Human) Prostate carcinoma
LNCaP-AR Homo sapiens (Human) Prostate carcinoma
LNCaP C4-2 Homo sapiens (Human) Prostate carcinoma
MR49F Homo sapiens (Human) Prostate carcinoma
LNCaP-hr Homo sapiens (Human) Prostate carcinoma
LNCap-ARR2PB-eGFP Homo sapiens (Human) Prostate carcinoma
Th17 Mus musculus (Mouse) -