Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US10633379, Compound X
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 PubChem ID
CID: 71600087
SID: 163680963
Canonical SMILES
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
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Compound Formula C22H19F2N3O4S
Compound Structure
Protein Name
 Protein Info 
Bromodomain-containing protein 4
Protein Classification
Epigenetic regulator
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Bromodomain
Uniprot ID
O60885
Gene Name
BRD4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000095 NCI-H1299
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 20 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1 nM
2 IC50 = 2.5 nM
3 IC50 = 3 nM
4 IC50 = 11 nM
5 IC50 = 39 nM
6 IC50 = 47 nM
7 IC50 = 69 nM
8 IC50 = 74 nM
9 Kd < 10 nM
10 Ki = 1.5 nM