General Information of the Protein
Protein ID
PT04657
Protein Name
Solute carrier family 2, facilitated glucose transporter member 1
Secondarily
Protein Name
Glucose transporter type 1
erythrocyte/brain
HepG2 glucose transporter
Gene Name
SLC2A1
Secondarily
Gene Name
GLUT1
Sequence
MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC02 family of hexose and sugar alcohol transporters
Function
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:10227690). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity).
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Uniprot ID
Primary ID:
P11166

Secondarily ID:
A8K9S6
B2R620
D3DPX0
O75535
Q0P512
Q147X2
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Ensembl ID
ENSG00000117394
HGNC ID
HGNC:11005
Subcellular Location
Cell membrane
Melanosome
Photoreceptor inner segment
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000068 , A-549
Compound ID Compound Name Compound Formula
CP0874390
2-(2-(4-chlorophenyl)-3-((4-(3-fluorobenzoyl)piperazin-1-yl)methyl)imidazo[1,2-a]pyridin-6-yl)benzonitrile
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C32H25ClFN5O
 2
1
IC50 = 77.62 nM
   TI
   LI
   LO
   TS
2
IC50 = 398.11 nM
   TI
   LI
   LO
   TS
CP0848862
(3S,3aS)-5-tert-butyl 3a-ethyl 1-(3,4-dimethoxyphenethyl)-3-(2-(naphthalen-1-ylmethylamino)-2-oxoethyl)-2-oxo-2,3,3a,4-tetrahydro-1H-pyrrolo[3,2-c]pyridine-3a,5(6H)-dicarboxylate
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C38H45N3O8
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0894513
(3S,3aR)-ethyl 3-(2-(4-(furan-2-carbonyl)piperazin-1-yl)-2-oxoethyl)-1-(naphthalen-1-ylmethyl)-2-oxo-2,3,3a,4,5,6,7,8-octahydro-1H-cycloocta[b]pyrrole-3a-carboxylate
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C35H39N3O6
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0031042
4-N-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide
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C24H16F4N6O2
 1
1 IC50 ~ 2 nM
Clinical Information about the Protein
Target 1 ( HepG2 glucose transporter (SLC2A1) )
Target Type Preclinical Target
Disease 1 Target-related Disease  1
1 Skin fibrosis [ICD-11: EM0Z]
Preclinical Drug(s) 1 Preclinical Drug  1
1 WZB-117 Preclinical
Skin fibrosis