Brief Information of the Cell Line and Protein
Cell Line ID: CL000095 , NCI-H1299
Synonyms
H1299
H-1299
NCIH1299
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0060
Protein ID: PT01017 , Serine/threonine-protein kinase pim-1
Gene Name PIM1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P11309
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000095  Protein ID: PT01017
 
Compound ID Compound Name Compound Formula
CP0200067
N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
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C18H19F3N6O
 1
1
EC50 = 45 nM
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CP0128906
3-[3-(dimethylamino)phenyl]-7-methoxy-N-(piperidin-4-ylmethyl)triazolo[4,5-b]pyridin-5-amine
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C20H27N7O
 1
1
EC50 = 48 nM
   TI
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CP0069651
7-methoxy-N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
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C19H21F3N6O2
 1
1
EC50 = 70 nM
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CP0139024
7-chloro-N-[(4-fluoropiperidin-4-yl)methyl]-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
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C23H24ClFN8O
 1
1
EC50 = 71 nM
   TI
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CP0165564
N-cyclohexyl-7-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)isoquinolin-1-amine
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C23H25N7O
 1
1
EC50 = 110 nM
   TI
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CP0126600
3-[3-(dimethylamino)phenyl]-N-(piperidin-4-ylmethyl)triazolo[4,5-b]pyridin-5-amine
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C19H25N7
 1
1
EC50 = 140 nM
   TI
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CP0140103
5,6-difluoro-N-[(4-fluoropiperidin-4-yl)methyl]-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
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C23H23F3N8O
 1
1
EC50 = 155 nM
   TI
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CP0134292
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-[(1-methylpiperidin-4-yl)methyl]quinolin-8-amine
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C24H28N8O
 1
1
EC50 = 179 nM
   TI
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CP0713718
N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine disulfate
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C20H24F3N5O5S
 1
1
EC50 = 200 nM
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CP0070817
N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
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C20H22F3N5O
 1
1
EC50 = 200 nM
   TI
   LI
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CP0139015
N-[(4-fluoropiperidin-4-yl)methyl]-7-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)isoquinolin-1-amine
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C23H25FN8O
 1
1
EC50 = 200 nM
   TI
   LI
   LO
   TS
CP0165554
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(1-methylpiperidin-4-yl)quinolin-8-amine
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C23H26N8O
 1
1
EC50 = 212 nM
   TI
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CP0134289
N-[(4-fluoropiperidin-4-yl)methyl]-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
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C23H25FN8O
 1
1
EC50 = 215 nM
   TI
   LI
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CP0306648
N-cyclohexyl-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
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C23H25N7O
 1
1
EC50 = 220 nM
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CP0139017
2-[10-(2-methoxyethyl)-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl]-N-(piperidin-4-ylmethyl)quinolin-8-amine
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C25H30N8O2
 1
1
EC50 = 262 nM
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CP0140104
N-cyclohexyl-7-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)naphthalen-1-amine
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C24H26N6O
 1
1
EC50 = 265 nM
   TI
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CP0139025
5-fluoro-N-[(4-fluoropiperidin-4-yl)methyl]-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
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C23H24F2N8O
 1
1
EC50 = 283 nM
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CP0140122
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(oxan-4-yl)quinolin-8-amine
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C22H23N7O2
 1
1
EC50 = 322 nM
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CP0160159
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(oxan-4-ylmethyl)quinolin-8-amine
   Show/Hide
C23H25N7O2
 1
1
EC50 = 325 nM
   TI
   LI
   LO
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CP0352349
N-[2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-yl]piperidine-4-carboxamide
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C23H24N8O2
 1
1
EC50 = 330 nM
   TI
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   TS
CP0323040
N-(7-azaspiro[3.5]nonan-2-yl)-3-[3-(trifluoromethyl)phenyl]triazolo[4,5-b]pyridin-5-amine
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C20H21F3N6
 1
1
EC50 = 380 nM
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CP0126713
4-[[3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-yl]amino]cyclohexan-1-ol
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C18H18F3N5O2
 1
1
EC50 = 405 nM
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CP0110465
6-chloro-N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
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C18H18ClF3N6O
 1
1
EC50 = 420 nM
   TI
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CP0551450
6-fluoro-N-[(4-fluoropiperidin-4-yl)methyl]-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
   Show/Hide
C23H24F2N8O
 1
1
EC50 = 465 nM
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   TS
CP0164528
4-[[3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-yl]amino]cyclohexan-1-ol
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C18H18F3N5O2
 1
1
EC50 = 550 nM
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CP0090814
N-(7-azaspiro[3.5]nonan-2-yl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
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C20H21F3N6O
 1
1
EC50 = 590 nM
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CP0282932
N-piperidin-4-yl-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
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C17H17F3N6O
 1
1
EC50 = 700 nM
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CP0177610
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(piperidin-4-ylmethyl)quinolin-8-amine
   Show/Hide
C23H26N8O
 1
1
EC50 = 700 nM
   TI
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CP0126602
N-(7-azaspiro[3.5]nonan-2-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
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C21H23F3N6O
 1
1
EC50 = 740 nM
   TI
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CP0134290
2-(10-ethyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(piperidin-4-ylmethyl)quinolin-8-amine
   Show/Hide
C24H28N8O
 1
1
EC50 = 780 nM
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CP0365953
N-(piperidin-4-ylmethyl)-2-(10-propyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
   Show/Hide
C25H30N8O
 1
1
EC50 = 800 nM
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CP0126603
N-(7-azaspiro[3.5]nonan-2-ylmethyl)-3-[3-(trifluoromethyl)phenyl]triazolo[4,5-b]pyridin-5-amine
   Show/Hide
C21H23F3N6
 1
1
EC50 = 810 nM
   TI
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CP0165556
7-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(piperidin-4-ylmethyl)naphthalen-1-amine
   Show/Hide
C24H27N7O
 1
1
EC50 = 865 nM
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CP0139018
N-(piperidin-4-ylmethyl)-2-(10-propan-2-yl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
   Show/Hide
C25H30N8O
 1
1
EC50 = 915 nM
   TI
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   TS
CP0139020
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-piperidin-4-ylquinolin-8-amine
   Show/Hide
C22H24N8O
 1
1
EC50 = 1380 nM
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CP0365952
2-[10-(2-phenoxyethyl)-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl]-N-(piperidin-4-ylmethyl)quinolin-8-amine
   Show/Hide
C30H32N8O2
 1
1
EC50 = 2020 nM
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CP0306649
7-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(piperidin-4-ylmethyl)isoquinolin-1-amine
   Show/Hide
C23H26N8O
 1
1
EC50 = 2510 nM
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CP0139013
1-[2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-yl]piperidin-4-amine
   Show/Hide
C22H24N8O
 1
1
EC50 = 5310 nM
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CP0177609
10-methyl-5-(8-piperazin-1-ylquinolin-2-yl)-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraene
   Show/Hide
C21H22N8O
 1
1
EC50 = 5360 nM
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CP0365954
N-[(4-fluoropiperidin-4-yl)methyl]-6-methyl-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
   Show/Hide
C24H27FN8O
 1
1
EC50 = 5960 nM
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