Compound ID |
Compound Name |
Compound Formula |
CP0200067
|
N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
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C18H19F3N6O
|
1
|
1 |
EC50 = 45 nM
|
|
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CP0128906
|
3-[3-(dimethylamino)phenyl]-7-methoxy-N-(piperidin-4-ylmethyl)triazolo[4,5-b]pyridin-5-amine
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|
C20H27N7O
|
1
|
1 |
EC50 = 48 nM
|
|
|
CP0069651
|
7-methoxy-N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
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|
C19H21F3N6O2
|
1
|
1 |
EC50 = 70 nM
|
|
|
CP0139024
|
7-chloro-N-[(4-fluoropiperidin-4-yl)methyl]-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
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|
C23H24ClFN8O
|
1
|
1 |
EC50 = 71 nM
|
|
|
CP0165564
|
N-cyclohexyl-7-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)isoquinolin-1-amine
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|
C23H25N7O
|
1
|
1 |
EC50 = 110 nM
|
|
|
CP0126600
|
3-[3-(dimethylamino)phenyl]-N-(piperidin-4-ylmethyl)triazolo[4,5-b]pyridin-5-amine
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|
C19H25N7
|
1
|
1 |
EC50 = 140 nM
|
|
|
CP0140103
|
5,6-difluoro-N-[(4-fluoropiperidin-4-yl)methyl]-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
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|
C23H23F3N8O
|
1
|
1 |
EC50 = 155 nM
|
|
|
CP0134292
|
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-[(1-methylpiperidin-4-yl)methyl]quinolin-8-amine
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|
C24H28N8O
|
1
|
1 |
EC50 = 179 nM
|
|
|
CP0713718
|
N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine disulfate
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|
C20H24F3N5O5S
|
1
|
1 |
EC50 = 200 nM
|
|
|
CP0070817
|
N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
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|
C20H22F3N5O
|
1
|
1 |
EC50 = 200 nM
|
|
|
CP0139015
|
N-[(4-fluoropiperidin-4-yl)methyl]-7-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)isoquinolin-1-amine
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|
C23H25FN8O
|
1
|
1 |
EC50 = 200 nM
|
|
|
CP0165554
|
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(1-methylpiperidin-4-yl)quinolin-8-amine
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|
C23H26N8O
|
1
|
1 |
EC50 = 212 nM
|
|
|
CP0134289
|
N-[(4-fluoropiperidin-4-yl)methyl]-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
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|
C23H25FN8O
|
1
|
1 |
EC50 = 215 nM
|
|
|
CP0306648
|
N-cyclohexyl-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
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|
C23H25N7O
|
1
|
1 |
EC50 = 220 nM
|
|
|
CP0139017
|
2-[10-(2-methoxyethyl)-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl]-N-(piperidin-4-ylmethyl)quinolin-8-amine
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|
C25H30N8O2
|
1
|
1 |
EC50 = 262 nM
|
|
|
CP0140104
|
N-cyclohexyl-7-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)naphthalen-1-amine
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|
C24H26N6O
|
1
|
1 |
EC50 = 265 nM
|
|
|
CP0139025
|
5-fluoro-N-[(4-fluoropiperidin-4-yl)methyl]-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
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|
C23H24F2N8O
|
1
|
1 |
EC50 = 283 nM
|
|
|
CP0140122
|
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(oxan-4-yl)quinolin-8-amine
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|
C22H23N7O2
|
1
|
1 |
EC50 = 322 nM
|
|
|
CP0160159
|
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(oxan-4-ylmethyl)quinolin-8-amine
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|
C23H25N7O2
|
1
|
1 |
EC50 = 325 nM
|
|
|
CP0352349
|
N-[2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-yl]piperidine-4-carboxamide
Show/Hide
|
C23H24N8O2
|
1
|
1 |
EC50 = 330 nM
|
|
|
CP0323040
|
N-(7-azaspiro[3.5]nonan-2-yl)-3-[3-(trifluoromethyl)phenyl]triazolo[4,5-b]pyridin-5-amine
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|
C20H21F3N6
|
1
|
1 |
EC50 = 380 nM
|
|
|
CP0126713
|
4-[[3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-yl]amino]cyclohexan-1-ol
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|
C18H18F3N5O2
|
1
|
1 |
EC50 = 405 nM
|
|
|
CP0110465
|
6-chloro-N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
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|
C18H18ClF3N6O
|
1
|
1 |
EC50 = 420 nM
|
|
|
CP0551450
|
6-fluoro-N-[(4-fluoropiperidin-4-yl)methyl]-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
Show/Hide
|
C23H24F2N8O
|
1
|
1 |
EC50 = 465 nM
|
|
|
CP0164528
|
4-[[3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-yl]amino]cyclohexan-1-ol
Show/Hide
|
C18H18F3N5O2
|
1
|
1 |
EC50 = 550 nM
|
|
|
CP0090814
|
N-(7-azaspiro[3.5]nonan-2-yl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
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|
C20H21F3N6O
|
1
|
1 |
EC50 = 590 nM
|
|
|
CP0282932
|
N-piperidin-4-yl-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
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|
C17H17F3N6O
|
1
|
1 |
EC50 = 700 nM
|
|
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CP0177610
|
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(piperidin-4-ylmethyl)quinolin-8-amine
Show/Hide
|
C23H26N8O
|
1
|
1 |
EC50 = 700 nM
|
|
|
CP0126602
|
N-(7-azaspiro[3.5]nonan-2-ylmethyl)-3-[3-(trifluoromethoxy)phenyl]triazolo[4,5-b]pyridin-5-amine
Show/Hide
|
C21H23F3N6O
|
1
|
1 |
EC50 = 740 nM
|
|
|
CP0134290
|
2-(10-ethyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(piperidin-4-ylmethyl)quinolin-8-amine
Show/Hide
|
C24H28N8O
|
1
|
1 |
EC50 = 780 nM
|
|
|
CP0365953
|
N-(piperidin-4-ylmethyl)-2-(10-propyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
Show/Hide
|
C25H30N8O
|
1
|
1 |
EC50 = 800 nM
|
|
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CP0126603
|
N-(7-azaspiro[3.5]nonan-2-ylmethyl)-3-[3-(trifluoromethyl)phenyl]triazolo[4,5-b]pyridin-5-amine
Show/Hide
|
C21H23F3N6
|
1
|
1 |
EC50 = 810 nM
|
|
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CP0165556
|
7-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(piperidin-4-ylmethyl)naphthalen-1-amine
Show/Hide
|
C24H27N7O
|
1
|
1 |
EC50 = 865 nM
|
|
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CP0139018
|
N-(piperidin-4-ylmethyl)-2-(10-propan-2-yl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
Show/Hide
|
C25H30N8O
|
1
|
1 |
EC50 = 915 nM
|
|
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CP0139020
|
2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-piperidin-4-ylquinolin-8-amine
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|
C22H24N8O
|
1
|
1 |
EC50 = 1380 nM
|
|
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CP0365952
|
2-[10-(2-phenoxyethyl)-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl]-N-(piperidin-4-ylmethyl)quinolin-8-amine
Show/Hide
|
C30H32N8O2
|
1
|
1 |
EC50 = 2020 nM
|
|
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CP0306649
|
7-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)-N-(piperidin-4-ylmethyl)isoquinolin-1-amine
Show/Hide
|
C23H26N8O
|
1
|
1 |
EC50 = 2510 nM
|
|
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CP0139013
|
1-[2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-yl]piperidin-4-amine
Show/Hide
|
C22H24N8O
|
1
|
1 |
EC50 = 5310 nM
|
|
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CP0177609
|
10-methyl-5-(8-piperazin-1-ylquinolin-2-yl)-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraene
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|
C21H22N8O
|
1
|
1 |
EC50 = 5360 nM
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|
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CP0365954
|
N-[(4-fluoropiperidin-4-yl)methyl]-6-methyl-2-(10-methyl-13-oxa-3,4,6,7,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,7-tetraen-5-yl)quinolin-8-amine
Show/Hide
|
C24H27FN8O
|
1
|
1 |
EC50 = 5960 nM
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|
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