Brief Information of the Compound and Protein
Compound Name
N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
    Show/Hide
PubChem ID
CID: 24795070
SID: 49738822
Canonical SMILES
CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
    Show/Hide
Compound Formula C20H22F3N5O
Compound Structure
Protein Name
Serine/threonine-protein kinase pim-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CAMK protein kinase group
>
CAMK protein kinase PIM family
Uniprot ID
P11309
Gene Name
PIM1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000095 NCI-H1299 Homo sapiens (Human)  1
1
EC50 = 200 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 7 nM
2 IC50 = 7.6 nM
3 IC50 = 13 nM
4 IC50 = 20 nM
5 IC50 = 46 nM
6 IC50 = 48 nM
7 Ki = 12 nM
8 Ki = 16 nM