| Compound ID |
Compound Name |
Compound Formula |
|
CP0361645
|
Chk1_152
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|
C25H25N3O6
|
1
|
| 1 |
EC50 = 40 nM
|
|
|
|
CP0136934
|
Chk1_136
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|
C27H22N4O6
|
1
|
| 1 |
EC50 = 50 nM
|
|
|
|
CP0422380
|
3-[3-methoxy-9-(3-methoxy-4-nitrophenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-2-yl]-N,N-dimethylpropanamide
Show/Hide
|
C26H26N4O6
|
1
|
| 1 |
EC50 = 50 nM
|
|
|
|
CP0295941
|
2-hydroxy-3-methoxy-9-(3-methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
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|
C21H17N3O6
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
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CP0172391
|
3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-6-(1H-pyrazol-4-yl)quinolin-2(1H)-one
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|
C26H25N5O
|
1
|
| 1 |
EC50 = 97 nM
|
|
|
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CP0352392
|
3-(5-((4-fluoropiperidin-1-yl)methyl)-1H-indol-2-yl)-6-(1H-pyrazol-4-yl)quinolin-2(1H)-one
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|
C26H24FN5O
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0347607
|
6-(1-methyl-1H-pyrazol-4-yl)-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)quinolin-2(1H)-one
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|
C27H27N5O
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0172389
|
3-(5-(morpholinomethyl)-1H-indol-2-yl)-6-(1H-pyrazol-4-yl)quinolin-2(1H)-one
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|
C25H23N5O2
|
1
|
| 1 |
EC50 = 170 nM
|
|
|
|
CP0172392
|
2-oxo-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-1,2-dihydroquinoline-6-carbonitrile
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|
C24H22N4O
|
1
|
| 1 |
EC50 = 170 nM
|
|
|
|
CP0210351
|
6-(isothiazol-4-yl)-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)quinolin-2(1H)-one
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|
C26H24N4OS
|
1
|
| 1 |
EC50 = 190 nM
|
|
|
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CP0215193
|
3-methoxy-9-(3-methoxy-4-nitrophenyl)-2-(oxan-2-ylmethoxy)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
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|
C27H27N3O7
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0277183
|
3-methoxy-9-(3-methoxy-4-nitrophenyl)-2-(2-morpholin-4-ylethoxy)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C27H28N4O7
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0361644
|
3-(3-hydroxypropyl)-2-methoxy-9-(3-methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
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|
C24H23N3O6
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
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CP0051735
|
3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-6-(1H-1,2,3-triazol-1-yl)quinolin-2(1H)-one
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|
C25H24N6O
|
1
|
| 1 |
EC50 = 230 nM
|
|
|
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CP0523734
|
3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-6-(1H-pyrazol-3-yl)quinolin-2(1H)-one
Show/Hide
|
C26H25N5O
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0295944
|
2,3-dimethoxy-9-(3-methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
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|
C22H19N3O6
|
1
|
| 1 |
EC50 = 280 nM
|
|
|
|
CP0529683
|
6-(1H-imidazol-1-yl)-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)quinolin-2(1H)-one
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|
C26H25N5O
|
1
|
| 1 |
EC50 = 320 nM
|
|
|
|
CP0348336
|
3-ethyl-2-methoxy-9-(3-methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
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|
C23H21N3O5
|
1
|
| 1 |
EC50 = 350 nM
|
|
|
|
CP0051736
|
3-(5-((4-acetylpiperazin-1-yl)methyl)-1H-indol-2-yl)-6-(1-methyl-1H-pyrazol-4-yl)quinolin-2(1H)-one
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|
C28H28N6O2
|
1
|
| 1 |
EC50 = 420 nM
|
|
|
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CP0036465
|
6-bromo-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)quinolin-2(1H)-one
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|
C23H22BrN3O
|
1
|
| 1 |
EC50 = 460 nM
|
|
|
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CP0347609
|
2-oxo-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-1,2-dihydroquinoline-6-carboxamide
Show/Hide
|
C24H24N4O2
|
1
|
| 1 |
EC50 = 520 nM
|
|
|
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CP0103446
|
2-(3-hydroxy-3-methylbutyl)-3-methoxy-9-(3-methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
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|
C26H27N3O6
|
1
|
| 1 |
EC50 = 600 nM
|
|
|
|
CP0352393
|
3-(5-((4-acetylpiperazin-1-yl)methyl)-1H-indol-2-yl)-6-(1H-pyrazol-4-yl)quinolin-2(1H)-one
Show/Hide
|
C27H26N6O2
|
1
|
| 1 |
EC50 = 870 nM
|
|
|
|
CP0194220
|
3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-6-(2H-1,2,3-triazol-2-yl)quinolin-2(1H)-one
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|
C25H24N6O
|
1
|
| 1 |
EC50 = 880 nM
|
|
|
|
CP0256901
|
2-(2-hydroxyethyl)-3-methoxy-9-(3-methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C23H21N3O6
|
1
|
| 1 |
EC50 = 900 nM
|
|
|
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CP0370390
|
3-(5-((4-(2-methoxyacetyl)piperazin-1-yl)methyl)-1H-indol-2-yl)-6-(1H-pyrazol-4-yl)quinolin-2(1H)-one
Show/Hide
|
C28H28N6O3
|
1
|
| 1 |
EC50 = 1142 nM
|
|
|
|
CP0370389
|
6-(2-methyl-2H-tetrazol-5-yl)-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)quinolin-2(1H)-one
Show/Hide
|
C25H25N7O
|
1
|
| 1 |
EC50 = 1300 nM
|
|
|
|
CP0321414
|
2-(3-hydroxypropyl)-3-methoxy-9-(3-methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C24H23N3O6
|
1
|
| 1 |
EC50 = 1500 nM
|
|
|
|
CP0256905
|
2-(4-hydroxybutoxy)-3-methoxy-9-(3-methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C25H25N3O7
|
1
|
| 1 |
EC50 = 2000 nM
|
|
|
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CP0035071
|
3-methoxy-9-(3-methoxy-4-nitrophenyl)-2-(2-pyridin-4-ylethyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C28H24N4O5
|
1
|
| 1 |
EC50 = 2100 nM
|
|
|
|
CP0256904
|
2-(3-aminopropoxy)-3-methoxy-9-(3-methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C24H24N4O6
|
1
|
| 1 |
EC50 = 2600 nM
|
|
|
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CP0103447
|
3-methoxy-2-[2-(2-methoxyethoxy)ethoxy]-9-(3-methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C26H27N3O8
|
1
|
| 1 |
EC50 = 3100 nM
|
|
|
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CP0195264
|
2-(2-hydroxyethoxy)-3-methoxy-9-(3-methoxy-4-nitrophenyl)-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C23H21N3O7
|
1
|
| 1 |
EC50 = 3100 nM
|
|
|
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CP0136930
|
2-methoxy-9-(3-methoxy-4-nitrophenyl)-N,N-dimethyl-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepine-3-carboxamide
Show/Hide
|
C24H22N4O6
|
1
|
| 1 |
EC50 = 3500 nM
|
|
|
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CP0215697
|
3-(5-((4-(aminomethyl)piperidin-1-yl)methyl)-1H-indol-2-yl)-2-oxo-1,2-dihydroquinoline-6-carbonitrile
Show/Hide
|
C25H25N5O
|
1
|
| 1 |
EC50 = 3700 nM
|
|
|
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CP0342012
|
3-(5-((4-(aminomethyl)piperidin-1-yl)methyl)-1H-indol-2-yl)-2-oxo-1,2-dihydroquinoline-6-carboxamide
Show/Hide
|
C25H27N5O2
|
1
|
| 1 |
EC50 = 3900 nM
|
|
|
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CP0338423
|
6-(3-hydroxyphenyl)-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)quinolin-2(1H)-one
Show/Hide
|
C29H27N3O2
|
1
|
| 1 |
EC50 = 6300 nM
|
|
|
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CP0256900
|
methyl 2-methoxy-9-(3-methoxy-4-nitrophenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepine-3-carboxylate
Show/Hide
|
C23H19N3O7
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
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CP0256902
|
methyl 3-[3-methoxy-9-(3-methoxy-4-nitrophenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-2-yl]propanoate
Show/Hide
|
C25H23N3O7
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
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CP0256903
|
3-methoxy-9-(3-methoxy-4-nitrophenyl)-2-[(2-methyl-1,3-thiazol-4-yl)methoxy]-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
Show/Hide
|
C26H22N4O6S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
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CP0503084
|
6-(4-hydroxy-3-methoxyphenyl)-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)quinolin-2(1H)-one
Show/Hide
|
C30H29N3O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
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CP0039009
|
3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL)-1,4-DIHYDROINDENO[1,2-C]PYRAZOLE-6-CARBOXAMIDE
Show/Hide
|
C29H27N3O3
|
1
|
| 1 |
EC50 > 10000 nM
|
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CP0212707
|
3-(4'-hydroxy-biphenyl-4-yl)-1,4-dihydro-indeno[1,2-c]pyrazole-6-carboxylic acid (pyridin-4-ylmethyl)-amide
Show/Hide
|
C29H22N4O2
|
1
|
| 1 |
EC50 > 10000 nM
|
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CP0373581
|
[3-[4-(4-hydroxyphenyl)phenyl]-1,4-dihydroindeno[1,2-c]pyrazol-6-yl]-(4-hydroxypiperidin-1-yl)methanone
Show/Hide
|
C28H25N3O3
|
1
|
| 1 |
EC50 > 10000 nM
|
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CP0400040
|
4'-[6-(4-Hydroxy-cyclohexylmethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]-biphenyl-4-ol
Show/Hide
|
C28H27N3O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
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CP0510897
|
4'-{6-[(trans-4-hydroxy-cyclohexylamino)-methyl]-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-biphenyl-4-ol
Show/Hide
|
C29H29N3O2
|
1
|
| 1 |
EC50 > 10000 nM
|
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