Brief Information of the Compound and Protein
Compound Name
2-oxo-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-1,2-dihydroquinoline-6-carbonitrile
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PubChem ID
CID: 44419935
SID: 99442306
Canonical SMILES
O=c1[nH]c2ccc(cc2cc1-c1cc2cc(CN3CCCCC3)ccc2[nH]1)C#N
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Compound Formula C24H22N4O
Compound Structure
Protein Name
Serine/threonine-protein kinase Chk1
Protein Classification
Enzyme
>
Kinase
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Protein Kinase
>
CAMK protein kinase group
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CAMK protein kinase CAMK1 family
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CAMK protein kinase CHK1 subfamily
Uniprot ID
O14757
Gene Name
CHEK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000095 NCI-H1299 Homo sapiens (Human)  1
1
EC50 = 170 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 4.6 nM