| Compound ID |
Compound Name |
Compound Formula |
|
CP0560122
|
6-(2,6-dichlorophenyl)-8-methyl-2-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]pyrido[2,3-d]pyrimidin-5-one
Show/Hide
|
C26H23Cl2N5O
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0114546
|
7-(2,6-dichlorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C26H23Cl2N7O
|
1
|
| 1 |
EC50 < 13 nM
|
|
|
|
CP0574421
|
6-(2,6-dichlorophenyl)-8-(difluoromethyl)-2-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]pyrido[4,3-d]pyrimidin-5-one
Show/Hide
|
C26H21Cl2F2N5O
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0530239
|
6-(2,6-dichlorophenyl)-8-ethyl-2-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]pyrido[2,3-d]pyrimidin-5-one
Show/Hide
|
C27H25Cl2N5O
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0574420
|
6-(2,6-dichlorophenyl)-8-ethenyl-2-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]pyrido[4,3-d]pyrimidin-5-one
Show/Hide
|
C27H23Cl2N5O
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0574747
|
8-cyclopropyl-6-(2,6-dichlorophenyl)-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-5-one
Show/Hide
|
C27H26Cl2N6O
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0530241
|
6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]pyrido[4,3-d]pyrimidin-5-one
Show/Hide
|
C26H23Cl2N5O2
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0114545
|
7-(2,6-dichlorophenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C26H21Cl2N7O
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0530240
|
6-(2,6-dichlorophenyl)-8-methyl-2-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]pyrido[4,3-d]pyrimidin-5-one
Show/Hide
|
C26H23Cl2N5O
|
1
|
| 1 |
EC50 = 28 nM
|
|
|
|
CP0142791
|
7-(2-chloro-6-fluorophenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C26H21ClFN7O
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0417039
|
6-(2,6-dichlorophenyl)-2-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-8H-pyrido[2,3-d]pyrimidin-5-one
Show/Hide
|
C25H21Cl2N5O
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0543043
|
8-cyclopropyl-6-(2,6-dichlorophenyl)-2-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]pyrido[2,3-d]pyrimidin-5-one
Show/Hide
|
C28H25Cl2N5O
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0425982
|
7-(2-chloro-6-fluorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C26H23ClFN7O
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0562543
|
6-(2,6-dichlorophenyl)-8-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-5-one
Show/Hide
|
C25H24Cl2N6O
|
1
|
| 1 |
EC50 = 79 nM
|
|
|
|
CP0379390
|
7-(2,6-dichlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C25H22Cl2N8O
|
1
|
| 1 |
EC50 = 87 nM
|
|
|
|
CP0360777
|
7-(2-chlorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C26H24ClN7O
|
1
|
| 1 |
EC50 = 98 nM
|
|
|
|
CP0142744
|
7-(2-chlorophenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C26H22ClN7O
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0410611
|
7-(2-chloro-6-fluorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C25H22ClFN8O
|
1
|
| 1 |
EC50 = 170 nM
|
|
|
|
CP0053076
|
7-(2-chlorophenyl)-12-[(2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C24H20ClN7O
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0417038
|
6-(2,6-dichlorophenyl)-2-[4-(4-methylpiperazin-1-yl)anilino]-8-phenylpyrido[2,3-d]pyrimidin-5-one
Show/Hide
|
C30H26Cl2N6O
|
1
|
| 1 |
EC50 = 246 nM
|
|
|
|
CP0384148
|
6-(2,6-dichlorophenyl)-2-[4-(4-methylpiperazin-1-yl)anilino]-8-(oxetan-3-yl)pyrido[2,3-d]pyrimidin-5-one
Show/Hide
|
C27H26Cl2N6O2
|
1
|
| 1 |
EC50 = 324 nM
|
|
|
|
CP0536595
|
7-(2-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C25H23ClN8O
|
1
|
| 1 |
EC50 = 370 nM
|
|
|
|
CP0114544
|
12-[(2-acetylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C27H22ClN7O2
|
1
|
| 1 |
EC50 = 620 nM
|
|
|
|
CP0142741
|
12-[4-(4-acetylpiperazin-1-yl)anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C26H23ClN8O2
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0271792
|
7-(2-chlorophenyl)-12-[3-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C25H23ClN8O
|
1
|
| 1 |
EC50 = 1500 nM
|
|
|
|
CP0142742
|
7-(2-chlorophenyl)-12-[(1-methyl-3,4-dihydro-2H-quinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C24H20ClN7O
|
1
|
| 1 |
EC50 = 2300 nM
|
|
|
|
CP0142743
|
7-(2-chlorophenyl)-12-[(1-methyl-3,4-dihydro-2H-quinolin-6-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C24H20ClN7O
|
1
|
| 1 |
EC50 = 2700 nM
|
|
|
|
CP0574418
|
6-(2,6-dichlorophenyl)-8-[2-(dimethylamino)ethyl]-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-5-one
Show/Hide
|
C28H31Cl2N7O
|
1
|
| 1 |
EC50 = 2850 nM
|
|
|
|
CP0550921
|
7-(2-chlorophenyl)-12-[4-(1-methylpiperidin-4-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C26H24ClN7O
|
1
|
| 1 |
EC50 = 3100 nM
|
|
|
|
CP0360776
|
7-(2-chlorophenyl)-12-(4-piperidin-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C25H22ClN7O
|
1
|
| 1 |
EC50 = 3800 nM
|
|
|
|
CP0574419
|
6-(2,6-dichlorophenyl)-8-(2-hydroxy-2-methylpropyl)-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-5-one
Show/Hide
|
C28H30Cl2N6O2
|
1
|
| 1 |
EC50 = 4020 nM
|
|
|
|
CP0554558
|
7-(2-chlorophenyl)-12-(5,6,7,8-tetrahydronaphthalen-2-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C24H19ClN6O
|
1
|
| 1 |
EC50 = 6000 nM
|
|
|
|
CP0120020
|
12-anilino-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C20H13ClN6O
|
1
|
| 1 |
EC50 = 6800 nM
|
|
|
|
CP0142740
|
7-(2-chlorophenyl)-12-(4-cyclohexylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one
Show/Hide
|
C26H23ClN6O
|
1
|
| 1 |
EC50 = 10000 nM
|
|
|
