Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-anilinoquinazoline deriv. 2
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 PubChem ID
CID: 4708
SID: 14877295
Canonical SMILES
Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1
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Compound Formula C17H13BrN4O
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431
 Cell Line Info 
Homo sapiens (Human)  4
1
IC50 = 2.7 nM
   TI
   LI
   LO
   TS
2
IC50 = 4.3 nM
   TI
   LI
   LO
   TS
3
IC50 = 12 nM
   TI
   LI
   LO
   TS
4
IC50 = 152 nM
   TI
   LI
   LO
   TS
CL000068 A-549
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 3.94 nM
   TI
   LI
   LO
   TS
2
IC50 = 17.9 nM
   TI
   LI
   LO
   TS
CL000157 NCI-H1975
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.08 nM
2 IC50 = 0.7 nM
3 IC50 < 1 nM
4 IC50 < 1.5 nM
5 IC50 = 2 nM
6 IC50 = 36 nM
7 IC50 = 3500 nM