General Information of the Compound
| Compound ID |
CP0664238
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| Compound Name |
N-(4-(2,4-dimethoxyphenylamino)quinazolin-6-yl)acrylamide
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| Structure |
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| Formula |
C19H18N4O3
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| Molecular Weight |
350.378
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| Canonical SMILES |
C=CC(=O)Nc1ccc2ncnc(Nc3ccc(OC)cc3OC)c2c1
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| InChI |
InChI=1S/C19H18N4O3/c1-4-18(24)22-12-5-7-15-14(9-12)19(21-11-20-15)23-16-8-6-13(25-2)10-17(16)26-3/h4-11H,1H2,2-3H3,(H,22,24)(H,20,21,23)
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| InChIKey |
HTWQUJPHCWCSKV-UHFFFAOYSA-N
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell Viability or Cytotoxicity Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000157 | NCI-H1975 | Homo sapiens (Human) | 1 |
| 1 |
IC50 = 13870 nM
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