General Information of the Compound
Compound ID
CP0386432
Compound Name
N-[3-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]-2-fluorophenyl]prop-2-enamide
    Show/Hide
Structure
Formula
C29H28FN9O
Molecular Weight
537.603
Canonical SMILES
CN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1nc2ccccc2n1-c1cccc(NC(=O)C=C)c1F
    Show/Hide
InChI
InChI=1S/C29H28FN9O/c1-3-25(40)34-21-8-6-10-24(26(21)30)39-23-9-5-4-7-20(23)36-29(39)27-28(31)32-16-22(35-27)18-15-33-38(17-18)19-11-13-37(2)14-12-19/h3-10,15-17,19H,1,11-14H2,2H3,(H2,31,32)(H,34,40)
    Show/Hide
InChIKey
BQTKEKJEPAKLCF-UHFFFAOYSA-N
Physicochemical Property
logP
4.4585
Rotatable Bonds
6
Heavy Atom Count
40
Polar Areas
119.78
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 127051448
ChEMBL ID
CHEMBL3814957
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000157 NCI-H1975 Homo sapiens (Human)  1
1
EC50 = 23 nM
   TI
   LI
   LO
   TS
CL000323 LoVo Homo sapiens (Human)  1
1
EC50 = 2060 nM
   TI
   LI
   LO
   TS