General Information of the Cell Line
Cell Line ID
CL000506
Cell Line Name
DMS 53
Synonyms
DMS-53
DMS53
Darmouth Medical School 53
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1177
Tissue Information
Lung
Disease
Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02659, Peptidyl-glycine alpha-amidating monooxygenase
Compound ID Compound Name Compound Formula
CP0088160
2-[(2S)-2-[[(2S)-2-[[(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]oxyacetic acid
   Show/Hide
C52H73N11O15S2
 1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0329460
2-[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-3-phenylpropanoyl]oxyacetic acid
   Show/Hide
C19H26N2O6
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0369146
2-[(2S)-2-acetamido-3-phenylpropanoyl]oxyacetic acid
   Show/Hide
C13H15NO5
 1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0088161
2-[(2S)-2-[[(2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]oxyacetic acid
   Show/Hide
C24H33N3O7
 1
1
IC50 = 6000 nM
   TI
   LI
   LO
   TS
CP0270205
2-[2-[[(2S)-2-[[(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]acetyl]oxyacetic acid
   Show/Hide
C45H67N11O15S2
 1
1
IC50 = 12000 nM
   TI
   LI
   LO
   TS
CP0341542
2-[2-[[(2S)-2-[(2S)-1-acetylpyrrolidine-2-carbonyl]oxy-4-methylpentanoyl]amino]acetyl]oxyacetic acid
   Show/Hide
C17H26N2O8
 1
1
IC50 = 76000 nM
   TI
   LI
   LO
   TS
CP0852116
2-((S)-2-((S)-2-((S)-1-((4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-sec-butyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)-3-phenylpropanamido)acetic acid
   Show/Hide
C52H74N12O14S2
 1
1
Km = 5000 nM
   TI
   LI
   LO
   TS
CP0812663
N-acetyl-(S)-prolyl-(S)-leucyl-(S)-phenylalanylglycine
   Show/Hide
C24H34N4O6
 1
1
Km = 6000 nM
   TI
   LI
   LO
   TS
CP0812664
N-acetyl-(S)-phenylalanylglycine
   Show/Hide
C13H16N2O4
 1
1
Km = 6000 nM
   TI
   LI
   LO
   TS
CP0768479
N-acetyl-(S)-leucyl-(S)-phenylalanylglycine
   Show/Hide
C19H27N3O5
 1
1
Km = 8000 nM
   TI
   LI
   LO
   TS
CP0776757
(3S,6S,9S,12S,18S,24S,27S)-1-((S)-1-((5S,8S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S,47S)-41-((1H-imidazol-5-yl)methyl)-5-((4R,7S,10S,13S,16S,22R)-22-amino-16-(2-amino-2-oxoethyl)-7-((R)-1-hydroxyethyl)-10-(hydroxymethyl)-13-isobutyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexaazacyclotricosane-4-carboxamido)-32-(2-amino-2-oxoethyl)-23-(3-amino-3-oxopropyl)-35-(4-aminobutyl)-29,38,47-tribenzyl-26-(carboxymethyl)-17-(4-hydroxybenzyl)-14,20,44-tris((R)-1-hydroxyethyl)-8-isobutyl-6,9,12,15,18,21,24,27,30,33,36,39,42,45-tetradecaoxo-2-thia-7,10,13,16,19,22,25,28,31,34,37,40,43,46-tetradecaazaoctatetracontane)pyrrolidin-2-yl)-3-(3-amino-3-oxopropyl)-27-benzyl-12-sec-butyl-6-((R)-1-hydroxyethyl)-18-isopropyl-9,24-dimethyl-1,4,7,10,13,16,19,22,25,28-decaoxo-2,5,8,11,14,17,20,23,26,29-decaazahentriacontan-31-oic acid
   Show/Hide
C157H230N40O47S3
 1
1
Km = 8000 nM
   TI
   LI
   LO
   TS
CP0905291
(S)-valylglycyl-(S)-alanyl-(S)-phenylalanylglycine
   Show/Hide
C21H31N5O6
 1
1
Km = 8000 nM
   TI
   LI
   LO
   TS
CP0738298
2-(2-((S)-2-((S)-1-((4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-sec-butyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)acetamido)acetic acid
   Show/Hide
C45H68N12O14S2
 1
1
Km = 36000 nM
   TI
   LI
   LO
   TS
CP0768478
glycyl-(S)-alanyl-(S)-phenylalanylglycine
   Show/Hide
C16H22N4O5
 1
1
Km = 40000 nM
   TI
   LI
   LO
   TS
CP0668936
(S)-alanyl-(S)-phenylalanylglycine
   Show/Hide
C14H19N3O4
 1
1
Km = 180000 nM
   TI
   LI
   LO
   TS
CP0850758
procalcitonin
   Show/Hide
C153H228N40O47S3
 1
1
Km = 200000 nM
   TI
   LI
   LO
   TS
CP0939905
N-acetyl-(S)-prolyl-(S)-leucylglycylglycine
   Show/Hide
C17H28N4O6
 1
1
Km = 660000 nM
   TI
   LI
   LO
   TS
CP0757335
N-acetyl-(S)-leucylglycylglycine
   Show/Hide
C12H21N3O5
 1
1
Km = 860000 nM
   TI
   LI
   LO
   TS
CP0138020
2-[[(2S)-pyrrolidine-2-carbonyl]amino]acetic acid
   Show/Hide
C7H12N2O3
 1
1
Km = 980000 nM
   TI
   LI
   LO
   TS
CP0816856
(S)-valylglycyl-(S)-alanyl-(S)-prolylglycine
   Show/Hide
C17H29N5O6
 1
1
Km = 1000000 nM
   TI
   LI
   LO
   TS
CP0709427
N-Acetylglycylglycine
   Show/Hide
C6H10N2O4
 1
1
Km = 1600000 nM
   TI
   LI
   LO
   TS
CP0812665
glycyl-(S)-alanyl-(S)-prolylglycine
   Show/Hide
C12H20N4O5
 1
1
Km = 3000000 nM
   TI
   LI
   LO
   TS
CP0837598
Ala-Pro-Gly
   Show/Hide
C10H17N3O4
 1
1
Km = 5000000 nM
   TI
   LI
   LO
   TS
CP0228451
((S)-2-Amino-3-phenyl-propionylamino)-acetic acid
   Show/Hide
C11H14N2O3
 1
1
Km = 6000000 nM
   TI
   LI
   LO
   TS
CP0071245
Substrate analogue, 15
   Show/Hide
C4H7NO3
 1
1
Km = 7500000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Lung)
Cell Line Name Organism Disease
T84 Homo sapiens (Human) Colon adenocarcinoma
CFBE41o- Homo sapiens (Human) Cystic fibrosis
A-549 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1975 Homo sapiens (Human) Lung adenocarcinoma
NCI-H2073 Homo sapiens (Human) Lung adenocarcinoma
HCC827 Homo sapiens (Human) Lung adenocarcinoma
NCI-H2228 Homo sapiens (Human) Lung adenocarcinoma
A-427 Homo sapiens (Human) Lung adenocarcinoma
HCC44 Homo sapiens (Human) Lung adenocarcinoma
HCC1171 Homo sapiens (Human) Lung adenocarcinoma
MR-5 Homo sapiens (Human) Lung adenocarcinoma
NCI-H522 Homo sapiens (Human) Lung adenocarcinoma
HCC366 Homo sapiens (Human) Lung adenosquamous carcinoma
NCI-H1581 Homo sapiens (Human) Lung large cell carcinoma
NCI-H1417 Homo sapiens (Human) Lung small cell carcinoma
SW900 Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H520 Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1703 Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H2286 Homo sapiens (Human) Lung squamous cell carcinoma
Malme-3M Homo sapiens (Human) Melanoma
NCI-H358 Homo sapiens (Human) Minimally invasive lung adenocarcinoma
LLTC Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
LLTC Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
T8 Rattus norvegicus (Rat) Rat malignant mesothelioma
V79MZ Cricetulus griseus (Chinese hamster) -
V79 Cricetulus griseus (Chinese hamster) -
V79MZh11B2 Cricetulus griseus (Chinese hamster) -
V79MZh11B1 Cricetulus griseus (Chinese hamster) -
Dede Cricetulus griseus (Chinese hamster) -
39ER22 Cricetulus griseus (Chinese hamster) -
PS120 Cricetulus griseus (Chinese hamster) -
CHL Cricetulus griseus (Chinese hamster) -
NP1 Homo sapiens (Human) -
IMR-90 Homo sapiens (Human) -
Hs 888.Lu Homo sapiens (Human) -
BEAS-2B Homo sapiens (Human) -
WI-38 Homo sapiens (Human) -
HL Homo sapiens (Human) -
HFL1 Homo sapiens (Human) -
WI-38 VA13 subline 2RA Homo sapiens (Human) -
HBE1 Homo sapiens (Human) -
16HBE14o- Homo sapiens (Human) -
NAL1A clone C4E10 Mus musculus (Mouse) -
Mv1Lu Neovison vison (American mink) -
RFL-6 Rattus norvegicus (Rat) -
PAC1 Rattus norvegicus (Rat) -
RLE Rattus norvegicus (Rat) -