General Information of the Cell Line
Cell Line ID
CL000662
Cell Line Name
HL
Synonyms
Human Lung
Category
Finite cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2492
Tissue Information
Lung
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01004, Alpha-1D adrenergic receptor
 Protein Info 
Compound ID Compound Name Compound Formula
CP0402532
 Compound Info 
(S)-3-{(1R,3R)-3-[4-(2-Cyano-phenyl)-piperazin-1-yl]-cyclopentylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C31H34F2N6O5
  1
1
Ki = 5.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0432824
 Compound Info 
(S)-3-{(1R,3S)-3-[4-(2-Cyano-phenyl)-piperazin-1-yl]-cyclopentylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C31H34F2N6O5
  1
1
Ki = 7.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0445362
 Compound Info 
(S)-3-{(1S,3S)-3-[4-(2-Cyano-phenyl)-piperazin-1-yl]-cyclopentylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C31H34F2N6O5
  1
1
Ki = 9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0528362
 Compound Info 
(S)-3-{(1S,3S)-3-[4-(2-Cyano-phenyl)-piperidin-1-yl]-cyclopentylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C32H35F2N5O5
  1
1
Ki = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463267
 Compound Info 
(S)-3-{(1R,3S)-3-[4-(2-Cyano-phenyl)-piperidin-1-yl]-cyclopentylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C32H35F2N5O5
  1
1
Ki = 16 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0455391
 Compound Info 
(S)-3-{(1R,3R)-3-[4-(2-Cyano-phenyl)-piperidin-1-yl]-cyclopentylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C32H35F2N5O5
  1
1
Ki = 31 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0455350
 Compound Info 
(S)-3-{(1S,3R)-3-[4-(2-Cyano-phenyl)-piperazin-1-yl]-cyclopentylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C31H34F2N6O5
  1
1
Ki = 39 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0406359
 Compound Info 
(S)-3-[(1S,3S)-3-(4-Cyano-4-phenyl-piperidin-1-yl)-cyclopentylcarbamoyl]-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C32H35F2N5O5
  1
1
Ki = 95 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0502347
 Compound Info 
(S)-3-{(1S,3R)-3-[4-(2-Cyano-phenyl)-piperidin-1-yl]-cyclopentylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C32H35F2N5O5
  1
1
Ki = 97 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463780
 Compound Info 
(S)-4-(3,4-Difluoro-phenyl)-6-methoxymethyl-2-oxo-3-[(1S,3S)-3-(3',4',5',6'-tetrahydro-2'H-[2,4']bipyridinyl-1'-yl)-cyclopentylcarbamoyl]-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C30H35F2N5O5
  1
1
Ki = 170 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0429286
 Compound Info 
(S)-4-(3,4-Difluoro-phenyl)-6-methoxymethyl-2-oxo-3-[(1R,3S)-3-(3',4',5',6'-tetrahydro-2'H-[2,4']bipyridinyl-1'-yl)-cyclopentylcarbamoyl]-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C30H35F2N5O5
  1
1
Ki = 320 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0502334
 Compound Info 
(S)-4-(3,4-Difluoro-phenyl)-6-methoxymethyl-2-oxo-3-[(1R,3R)-3-(3',4',5',6'-tetrahydro-2'H-[2,4']bipyridinyl-1'-yl)-cyclopentylcarbamoyl]-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C30H35F2N5O5
  1
1
Ki = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0465015
 Compound Info 
(S)-4-(3,4-Difluoro-phenyl)-6-methoxymethyl-2-oxo-3-[(1S,3R)-3-(3',4',5',6'-tetrahydro-2'H-[2,4']bipyridinyl-1'-yl)-cyclopentylcarbamoyl]-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C30H35F2N5O5
  1
1
Ki = 550 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463641
 Compound Info 
methyl (4S)-3-[[(1R,3S)-3-(4-cyano-4-phenylpiperidin-1-yl)cyclopentyl]carbamoyl]-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate
   Show/Hide
C32H35F2N5O5
  1
1
Ki = 620 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0448487
 Compound Info 
(S)-3-[(1S,3R)-3-(4-Cyano-4-phenyl-piperidin-1-yl)-cyclopentylcarbamoyl]-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C32H35F2N5O5
  1
1
Ki = 660 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0453018
 Compound Info 
(S)-3-[(1R,3R)-3-(4-Cyano-4-phenyl-piperidin-1-yl)-cyclopentylcarbamoyl]-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
   Show/Hide
C32H35F2N5O5
  1
1
Ki = 660 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Lung)
Cell Line Name Organism Disease
T84
 Cell Line Info 
Homo sapiens (Human) Colon adenocarcinoma
CFBE41o-
 Cell Line Info 
Homo sapiens (Human) Cystic fibrosis
A-549
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1975
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2073
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC827
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2228
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
A-427
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC44
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC1171
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
MR-5
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H522
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC366
 Cell Line Info 
Homo sapiens (Human) Lung adenosquamous carcinoma
NCI-H1581
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
DMS 53
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H1417
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
SW900
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H520
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1703
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H2286
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
Malme-3M
 Cell Line Info 
Homo sapiens (Human) Melanoma
NCI-H358
 Cell Line Info 
Homo sapiens (Human) Minimally invasive lung adenocarcinoma
LLTC
 Cell Line Info 
Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
LLTC
 Cell Line Info 
Mus musculus (Mouse) Malignant tumors of the mouse pulmonary system
T8
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant mesothelioma
V79MZ
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79MZh11B2
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
V79MZh11B1
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
Dede
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
39ER22
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
PS120
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
CHL
 Cell Line Info 
Cricetulus griseus (Chinese hamster) -
NP1
 Cell Line Info 
Homo sapiens (Human) -
IMR-90
 Cell Line Info 
Homo sapiens (Human) -
Hs 888.Lu
 Cell Line Info 
Homo sapiens (Human) -
BEAS-2B
 Cell Line Info 
Homo sapiens (Human) -
WI-38
 Cell Line Info 
Homo sapiens (Human) -
HFL1
 Cell Line Info 
Homo sapiens (Human) -
WI-38 VA13 subline 2RA
 Cell Line Info 
Homo sapiens (Human) -
HBE1
 Cell Line Info 
Homo sapiens (Human) -
16HBE14o-
 Cell Line Info 
Homo sapiens (Human) -
NAL1A clone C4E10
 Cell Line Info 
Mus musculus (Mouse) -
Mv1Lu
 Cell Line Info 
Neovison vison (American mink) -
RFL-6
 Cell Line Info 
Rattus norvegicus (Rat) -
PAC1
 Cell Line Info 
Rattus norvegicus (Rat) -
RLE
 Cell Line Info 
Rattus norvegicus (Rat) -