Brief Information of the Compound and Protein
Compound Name
N-[3-[2-[3-amino-6-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]-N-methylprop-2-enamide
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PubChem ID
CID: 127050550
Canonical SMILES
CN(C(=O)C=C)c1cccc(c1)-n1c(nc2ccccc12)-c1nc(cnc1N)-c1cnn(c1)C1CCN(C)CC1
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Compound Formula C30H31N9O
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000323 LoVo Homo sapiens (Human)  1
1
EC50 = 10900 nM
   TI
   LI
   LO
   TS
CL000157 NCI-H1975 Homo sapiens (Human)  1
1
EC50 = 390 nM
   TI
   LI
   LO
   TS