Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[(3R,4R)-1-[6-[(1,3-dimethylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide
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 PubChem ID
CID: 118073729
Canonical SMILES
CC(C)n1cnc2c(Nc3cn(C)nc3C)nc(nc12)N1C[C@@H](F)[C@@H](C1)NC(=O)C=C
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Compound Formula C20H26FN9O
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 1450 nM
   TI
   LI
   LO
   TS
2
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CL000157 NCI-H1975
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
2
IC50 = 6138 nM
   TI
   LI
   LO
   TS
CL000379 PC-9
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CL000923 PC9-DRH
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 17 nM