General Information of the Compound
Compound ID
CP0489265
Compound Name
4-(benzhydrylamino)-2-piperazin-1-yl-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
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Structure
Formula
C26H30N6O
Molecular Weight
442.567
Canonical SMILES
CC(C)N1Cc2c(nc(nc2NC(c2ccccc2)c2ccccc2)N2CCNCC2)C1=O
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InChI
InChI=1S/C26H30N6O/c1-18(2)32-17-21-23(25(32)33)29-26(31-15-13-27-14-16-31)30-24(21)28-22(19-9-5-3-6-10-19)20-11-7-4-8-12-20/h3-12,18,22,27H,13-17H2,1-2H3,(H,28,29,30)
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InChIKey
JQCUOJJGMALZGI-UHFFFAOYSA-N
Physicochemical Property
logP
3.4519
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
73.39
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25117612
SID: 56441809
ChEMBL ID
CHEMBL2010929
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03393, P2X purinoceptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000761 RLE Rattus norvegicus (Rat)  1
1
IC50 = 618 nM
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