General Information of the Compound
Compound ID
CP0475821
Compound Name
4-(benzhydrylamino)-2-(4-methylpiperazin-1-yl)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
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Structure
Formula
C27H32N6O
Molecular Weight
456.594
Canonical SMILES
CC(C)N1Cc2c(nc(nc2NC(c2ccccc2)c2ccccc2)N2CCN(C)CC2)C1=O
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InChI
InChI=1S/C27H32N6O/c1-19(2)33-18-22-24(26(33)34)29-27(32-16-14-31(3)15-17-32)30-25(22)28-23(20-10-6-4-7-11-20)21-12-8-5-9-13-21/h4-13,19,23H,14-18H2,1-3H3,(H,28,29,30)
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InChIKey
CYDJGGOXXCSUBQ-UHFFFAOYSA-N
Physicochemical Property
logP
3.7941
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
64.6
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57658920
ChEMBL ID
CHEMBL2010932
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03393, P2X purinoceptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000761 RLE Rattus norvegicus (Rat)  1
1
IC50 = 1947 nM
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