General Information of the Compound
Compound ID
CP0513883
Compound Name
2-(4-acetylpiperazin-1-yl)-4-[[1-(4-chlorophenyl)cyclobutyl]methylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-one
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Structure
Formula
C26H33ClN6O2
Molecular Weight
497.043
Canonical SMILES
CC(C)N1Cc2c(nc(nc2NCC2(CCC2)c2ccc(Cl)cc2)N2CCN(CC2)C(C)=O)C1=O
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InChI
InChI=1S/C26H33ClN6O2/c1-17(2)33-15-21-22(24(33)35)29-25(32-13-11-31(12-14-32)18(3)34)30-23(21)28-16-26(9-4-10-26)19-5-7-20(27)8-6-19/h5-8,17H,4,9-16H2,1-3H3,(H,28,29,30)
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InChIKey
YFZDMDKJMXKVQS-UHFFFAOYSA-N
Physicochemical Property
logP
3.6965
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
81.67
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57431769
ChEMBL ID
CHEMBL2011111
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03393, P2X purinoceptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000761 RLE Rattus norvegicus (Rat)  1
1
IC50 = 262 nM
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